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The effects and possible mechanism of action of apolipoprotein M on the growth of breast cancer cells

Zhou, Ying ; Yao, Shuang ; Yu, Miaomei ; Wei, Jiang ; Fang, Qi ; Xu, Ning LU and Luo, Guanghua (2022) In Molecular Biology Reports 49(2). p.1171-1179
Abstract

Background: To investigate the effects and mechanism of action of apolipoprotein M (ApoM) on the growth of breast cancer (BC) cells. Methods and results: Bioinformatics, cell experiments and animal experiments were used to verify the effect of ApoM on breast cancer cell lines and breast tumor growth in vivo. ApoM expression was significantly reduced in BC tissues, and patients with lower ApoM mRNA expression had a poorer prognosis (P < 0.0001). Besides, ApoM can partially inhibit the proliferative, migratory and invasive processes of BC cells. In vivo, the difference between ApoM-OE and NC groups was no significant. The level of vitamin D receptor (VDR) protein in MDA-MB-231 cells was increased by overexpression of ApoM (P <... (More)

Background: To investigate the effects and mechanism of action of apolipoprotein M (ApoM) on the growth of breast cancer (BC) cells. Methods and results: Bioinformatics, cell experiments and animal experiments were used to verify the effect of ApoM on breast cancer cell lines and breast tumor growth in vivo. ApoM expression was significantly reduced in BC tissues, and patients with lower ApoM mRNA expression had a poorer prognosis (P < 0.0001). Besides, ApoM can partially inhibit the proliferative, migratory and invasive processes of BC cells. In vivo, the difference between ApoM-OE and NC groups was no significant. The level of vitamin D receptor (VDR) protein in MDA-MB-231 cells was increased by overexpression of ApoM (P < 0.05), while in MCF-7 cells, VDR levels decreased (P < 0.05). Conclusions: ApoM can partially inhibit the growth of BC cells. VDR may play a role, but is not the main pathway.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Apolipoprotein M, Biological behavior, Breast cancer, Tumor in situ, Vitamin D receptor
in
Molecular Biology Reports
volume
49
issue
2
pages
1171 - 1179
publisher
Springer
external identifiers
  • scopus:85119337302
  • pmid:34775573
ISSN
0301-4851
DOI
10.1007/s11033-021-06945-2
language
English
LU publication?
yes
id
906d34da-c2c9-45eb-bd1c-aa401b2ae86b
date added to LUP
2021-12-13 14:16:52
date last changed
2024-12-29 18:58:46
@article{906d34da-c2c9-45eb-bd1c-aa401b2ae86b,
  abstract     = {{<p>Background: To investigate the effects and mechanism of action of apolipoprotein M (ApoM) on the growth of breast cancer (BC) cells. Methods and results: Bioinformatics, cell experiments and animal experiments were used to verify the effect of ApoM on breast cancer cell lines and breast tumor growth in vivo. ApoM expression was significantly reduced in BC tissues, and patients with lower ApoM mRNA expression had a poorer prognosis (P &lt; 0.0001). Besides, ApoM can partially inhibit the proliferative, migratory and invasive processes of BC cells. In vivo, the difference between ApoM-OE and NC groups was no significant. The level of vitamin D receptor (VDR) protein in MDA-MB-231 cells was increased by overexpression of ApoM (P &lt; 0.05), while in MCF-7 cells, VDR levels decreased (P &lt; 0.05). Conclusions: ApoM can partially inhibit the growth of BC cells. VDR may play a role, but is not the main pathway.</p>}},
  author       = {{Zhou, Ying and Yao, Shuang and Yu, Miaomei and Wei, Jiang and Fang, Qi and Xu, Ning and Luo, Guanghua}},
  issn         = {{0301-4851}},
  keywords     = {{Apolipoprotein M; Biological behavior; Breast cancer; Tumor in situ; Vitamin D receptor}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{1171--1179}},
  publisher    = {{Springer}},
  series       = {{Molecular Biology Reports}},
  title        = {{The effects and possible mechanism of action of apolipoprotein M on the growth of breast cancer cells}},
  url          = {{http://dx.doi.org/10.1007/s11033-021-06945-2}},
  doi          = {{10.1007/s11033-021-06945-2}},
  volume       = {{49}},
  year         = {{2022}},
}