Female reproductive abnormalities in mouse adolescent pregnancy
Yang, Chen ; Li, Yue ; Pan, Hai Yang ; Li, Meng Yuan ; Pan, Ji Min ; Chen, Si Ting ; Zhang, Hai Yi ; Yang, Zhen Shan LU
; Dou, Hai Ting
and Yang, Zeng Ming
(2021)
In Reproduction
162(5).
p.353-365
- Abstract
There are around 300 million adolescent pregnancies worldwide, accounting for 11% of all births worldwide. Accumulating evidence demonstrates that many adverse perinatal outcomes are associated with adolescent pregnancies. However, how and why these abnormalities occur remain to be defined. In this study, pregnancy at different stages was compared between 25- and 30- day-old and mature female mice. We found that the litter size of adolescent pregnancy is significantly decreased from F1 to F3 generations compared to mature pregnancy. On days 8 and 12 of pregnancy, multiple abnormalities in decidual and placental development appear in F3 adolescent pregnancy. On days 5 and 8, uterine endoplasmic reticulum stress is dysregulated in F3... (More)
There are around 300 million adolescent pregnancies worldwide, accounting for 11% of all births worldwide. Accumulating evidence demonstrates that many adverse perinatal outcomes are associated with adolescent pregnancies. However, how and why these abnormalities occur remain to be defined. In this study, pregnancy at different stages was compared between 25- and 30- day-old and mature female mice. We found that the litter size of adolescent pregnancy is significantly decreased from F1 to F3 generations compared to mature pregnancy. On days 8 and 12 of pregnancy, multiple abnormalities in decidual and placental development appear in F3 adolescent pregnancy. On days 5 and 8, uterine endoplasmic reticulum stress is dysregulated in F3 adolescent pregnancy. Embryo implantation and decidualization are also compromised in adolescent pregnancy. Many genes are abnormally expressed in adolescent estrous uteri. The abnormal endocrine environment and abnormal implantation from uterine immaturity may result in multiple pregnancy failures in adolescent pregnancy. The aim of this study is to shed light on human adolescent pregnancy.
(Less)
- author
- Yang, Chen
; Li, Yue
; Pan, Hai Yang
; Li, Meng Yuan
; Pan, Ji Min
; Chen, Si Ting
; Zhang, Hai Yi
; Yang, Zhen Shan
LU
; Dou, Hai Ting
and Yang, Zeng Ming
- publishing date
- 2021-11
- type
- Contribution to journal
- publication status
- published
- in
- Reproduction
- volume
- 162
- issue
- 5
- pages
- 353 - 365
- publisher
- BioScientifica
- external identifiers
-
- pmid:34486978
- scopus:85117930608
- ISSN
- 1470-1626
- DOI
- 10.1530/REP-21-0240
- language
- English
- LU publication?
- no
- additional info
- Funding Information: This work was supported by National Key Research and Development Program of China (2018YFC1004400) and National Natural Science Foundation of China (31871511 and 31671563). Publisher Copyright: © 2021 Society for Reproduction and Fertility
- id
- 906e8b4e-b49e-40a1-8c24-e921c001b3c0
- date added to LUP
- 2024-02-28 14:57:34
- date last changed
- 2024-03-30 09:32:00
@article{906e8b4e-b49e-40a1-8c24-e921c001b3c0,
abstract = {{<p>There are around 300 million adolescent pregnancies worldwide, accounting for 11% of all births worldwide. Accumulating evidence demonstrates that many adverse perinatal outcomes are associated with adolescent pregnancies. However, how and why these abnormalities occur remain to be defined. In this study, pregnancy at different stages was compared between 25- and 30- day-old and mature female mice. We found that the litter size of adolescent pregnancy is significantly decreased from F1 to F3 generations compared to mature pregnancy. On days 8 and 12 of pregnancy, multiple abnormalities in decidual and placental development appear in F3 adolescent pregnancy. On days 5 and 8, uterine endoplasmic reticulum stress is dysregulated in F3 adolescent pregnancy. Embryo implantation and decidualization are also compromised in adolescent pregnancy. Many genes are abnormally expressed in adolescent estrous uteri. The abnormal endocrine environment and abnormal implantation from uterine immaturity may result in multiple pregnancy failures in adolescent pregnancy. The aim of this study is to shed light on human adolescent pregnancy.</p>}},
author = {{Yang, Chen and Li, Yue and Pan, Hai Yang and Li, Meng Yuan and Pan, Ji Min and Chen, Si Ting and Zhang, Hai Yi and Yang, Zhen Shan and Dou, Hai Ting and Yang, Zeng Ming}},
issn = {{1470-1626}},
language = {{eng}},
number = {{5}},
pages = {{353--365}},
publisher = {{BioScientifica}},
series = {{Reproduction}},
title = {{Female reproductive abnormalities in mouse adolescent pregnancy}},
url = {{http://dx.doi.org/10.1530/REP-21-0240}},
doi = {{10.1530/REP-21-0240}},
volume = {{162}},
year = {{2021}},
}