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Gastric inflammatory markers and interleukins in patients with functional dyspepsia treated with astaxanthin

Percival Andersen, Leif; Holck, Susanne; Kupcinskas, Limas; Kiudelis, Gediminas; Jonaitis, Laimas; Janciauskas, Dainius; Permin, Henrik and Wadström, Torkel LU (2007) In Pathogens and Disease 50(2). p.244-248
Abstract
The chronic active inflammation caused by Helicobacter pylori is dominated by neutrophils, macrophages, lymphocytes and plasma cells. Several interleukins are involved in the inflammatory process. The aim of this study was to investigate the effect of astaxanthin on gastric inflammation in patients with functional dyspepsia. Forty-four consecutive patients were included, and biopsies were examined for IL-4, IL-6, IL-8, IL-10, interferon-gamma, CD4, CD8, CD14, CD19, CD25 and CD30. Patients were randomized: 21 patients were treated with 40 mg of astaxanthin daily, and 23 patients were treated with a placebo. There was a significant decrease in gastric inflammation in H. pylori-positive patients from both groups. There were no significant... (More)
The chronic active inflammation caused by Helicobacter pylori is dominated by neutrophils, macrophages, lymphocytes and plasma cells. Several interleukins are involved in the inflammatory process. The aim of this study was to investigate the effect of astaxanthin on gastric inflammation in patients with functional dyspepsia. Forty-four consecutive patients were included, and biopsies were examined for IL-4, IL-6, IL-8, IL-10, interferon-gamma, CD4, CD8, CD14, CD19, CD25 and CD30. Patients were randomized: 21 patients were treated with 40 mg of astaxanthin daily, and 23 patients were treated with a placebo. There was a significant decrease in gastric inflammation in H. pylori-positive patients from both groups. There were no significant changes in the density of H. pylori or in any of the interleukins during or after treatment. There was a significant up-regulation of CD4 and down-regulation of CD8 in patients with H. pylori treated with astaxanthin. Astaxanthin had an effect on the inflammation and on the density of H. pylori in mice in a study where the diet could be standardized without antioxidants (Bennedsen et al., 1999). These dietary conditions are impossible in studies involving humans, and may be due to the minor effect when the host have access to antioxidants in their diet. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
CD8, gastritis, gastric inflammation, astaxanthin, CD4, interleukins
in
Pathogens and Disease
volume
50
issue
2
pages
244 - 248
publisher
Wiley-Blackwell
external identifiers
  • wos:000247226000014
  • scopus:34250329090
ISSN
2049-632X
DOI
10.1111/j.1574-695X.2007.00257.x
language
English
LU publication?
yes
id
a04b0eaa-cfce-4f30-91b3-fce836a81373 (old id 907754)
date added to LUP
2008-01-09 15:50:58
date last changed
2017-06-04 03:40:50
@article{a04b0eaa-cfce-4f30-91b3-fce836a81373,
  abstract     = {The chronic active inflammation caused by Helicobacter pylori is dominated by neutrophils, macrophages, lymphocytes and plasma cells. Several interleukins are involved in the inflammatory process. The aim of this study was to investigate the effect of astaxanthin on gastric inflammation in patients with functional dyspepsia. Forty-four consecutive patients were included, and biopsies were examined for IL-4, IL-6, IL-8, IL-10, interferon-gamma, CD4, CD8, CD14, CD19, CD25 and CD30. Patients were randomized: 21 patients were treated with 40 mg of astaxanthin daily, and 23 patients were treated with a placebo. There was a significant decrease in gastric inflammation in H. pylori-positive patients from both groups. There were no significant changes in the density of H. pylori or in any of the interleukins during or after treatment. There was a significant up-regulation of CD4 and down-regulation of CD8 in patients with H. pylori treated with astaxanthin. Astaxanthin had an effect on the inflammation and on the density of H. pylori in mice in a study where the diet could be standardized without antioxidants (Bennedsen et al., 1999). These dietary conditions are impossible in studies involving humans, and may be due to the minor effect when the host have access to antioxidants in their diet.},
  author       = {Percival Andersen, Leif and Holck, Susanne and Kupcinskas, Limas and Kiudelis, Gediminas and Jonaitis, Laimas and Janciauskas, Dainius and Permin, Henrik and Wadström, Torkel},
  issn         = {2049-632X},
  keyword      = {CD8,gastritis,gastric inflammation,astaxanthin,CD4,interleukins},
  language     = {eng},
  number       = {2},
  pages        = {244--248},
  publisher    = {Wiley-Blackwell},
  series       = {Pathogens and Disease},
  title        = {Gastric inflammatory markers and interleukins in patients with functional dyspepsia treated with astaxanthin},
  url          = {http://dx.doi.org/10.1111/j.1574-695X.2007.00257.x},
  volume       = {50},
  year         = {2007},
}