CHEK2 1100delC in patients with metachronous cancers of the breast and the colorectum
Isinger Ekstrand, Anna LU
; Bhat, M
LU
; Borg, Åke
LU
and Nilbert, Mef
LU
(2006)
In BMC Cancer
6.
- Abstract
- Background: Development of multiple primary tumors is a hallmark of hereditary cancer. At least 1/10 of breast cancers and colorectal cancers occur because of heredity and recently the cell cycle kinase 2, CHEK2 1100delC allele has been identified at a particularly high frequency in families with hereditary breast and colorectal cancer. Methods: We utilized the Southern Sweden population-based cancer registry to identify women with double primary breast and colorectal cancer and sequenced tumor material in order to assess the contribution of the CHEK2 1100delC to the development of such metachronous tumors. Results: Among the 75 patients successfully analyzed, 2 (2.5%) carried the CHEK2 1100delC allele. which was not significantly... (More)
- Background: Development of multiple primary tumors is a hallmark of hereditary cancer. At least 1/10 of breast cancers and colorectal cancers occur because of heredity and recently the cell cycle kinase 2, CHEK2 1100delC allele has been identified at a particularly high frequency in families with hereditary breast and colorectal cancer. Methods: We utilized the Southern Sweden population-based cancer registry to identify women with double primary breast and colorectal cancer and sequenced tumor material in order to assess the contribution of the CHEK2 1100delC to the development of such metachronous tumors. Results: Among the 75 patients successfully analyzed, 2 (2.5%) carried the CHEK2 1100delC allele. which was not significantly different (p = 0.26) from the 1% (3/300) carriers identified in the control group. Conclusion: In summary, our data suggest that the CHEK2 1100delC is not a major cause of double primary breast and colorectal cancer in Sweden, which suggests that this patient group should not routinely be screened for the CHEK2 1100delC variant. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/908739
- author
- Isinger Ekstrand, Anna
LU
; Bhat, M
LU
; Borg, Åke
LU
and Nilbert, Mef
LU
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- in
- BMC Cancer
- volume
- 6
- article number
- 64
- publisher
- BioMed Central (BMC)
- external identifiers
-
- wos:000236547000003
- pmid:16539695
- scopus:33645471674
- ISSN
- 1471-2407
- DOI
- 10.1186/1471-2407-6-64
- language
- English
- LU publication?
- yes
- id
- a64f2564-4a40-488d-8f36-c4ec987f4a34 (old id 908739)
- date added to LUP
- 2016-04-01 15:55:09
- date last changed
- 2022-01-28 08:00:37
@article{a64f2564-4a40-488d-8f36-c4ec987f4a34,
abstract = {{Background: Development of multiple primary tumors is a hallmark of hereditary cancer. At least 1/10 of breast cancers and colorectal cancers occur because of heredity and recently the cell cycle kinase 2, CHEK2 1100delC allele has been identified at a particularly high frequency in families with hereditary breast and colorectal cancer. Methods: We utilized the Southern Sweden population-based cancer registry to identify women with double primary breast and colorectal cancer and sequenced tumor material in order to assess the contribution of the CHEK2 1100delC to the development of such metachronous tumors. Results: Among the 75 patients successfully analyzed, 2 (2.5%) carried the CHEK2 1100delC allele. which was not significantly different (p = 0.26) from the 1% (3/300) carriers identified in the control group. Conclusion: In summary, our data suggest that the CHEK2 1100delC is not a major cause of double primary breast and colorectal cancer in Sweden, which suggests that this patient group should not routinely be screened for the CHEK2 1100delC variant.}},
author = {{Isinger Ekstrand, Anna and Bhat, M and Borg, Åke and Nilbert, Mef}},
issn = {{1471-2407}},
language = {{eng}},
publisher = {{BioMed Central (BMC)}},
series = {{BMC Cancer}},
title = {{CHEK2 1100delC in patients with metachronous cancers of the breast and the colorectum}},
url = {{http://dx.doi.org/10.1186/1471-2407-6-64}},
doi = {{10.1186/1471-2407-6-64}},
volume = {{6}},
year = {{2006}},
}