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Occupational risk factors for small bowel carcinoid tumor: A European population-based case-control study

Kaerlev, L; Teglbjaerg, PS; Sabroe, S; Kolstad, HA; Ahrens, W; Eriksson, Mikael LU ; Guenel, P; Hardell, L; Cyr, D and Ballard, T, et al. (2002) In Journal of Occupational and Environmental Medicine 44(6). p.516-522
Abstract
Small bowel carcinoid tumor (SBC) is a rare disease of unknown etiology bill with all age-, sex-, and place-specific occurrence that may indicate an occupational origin. A European multicenter population-based case-control study was conducted from 1995 through 1997. Incident SBC cases between 35 and 69 years of age (n = 101) were identified, together with 3335 controls sampled from the catchment area of the cases. Histological review performed by a reference pathologist left 99 cases for study; 84 cases and 2070 population controls were interviewed. The industries most closely associated (a twofold or more odds ratio [OR]) with SBC taking into account a 10-year time lag after exposure were, among women, employment in wholesale industry of... (More)
Small bowel carcinoid tumor (SBC) is a rare disease of unknown etiology bill with all age-, sex-, and place-specific occurrence that may indicate an occupational origin. A European multicenter population-based case-control study was conducted from 1995 through 1997. Incident SBC cases between 35 and 69 years of age (n = 101) were identified, together with 3335 controls sampled from the catchment area of the cases. Histological review performed by a reference pathologist left 99 cases for study; 84 cases and 2070 population controls were interviewed. The industries most closely associated (a twofold or more odds ratio [OR]) with SBC taking into account a 10-year time lag after exposure were, among women, employment in wholesale industry of food and beverages (OR, 8.2; 95% confidence interval [CI], [1.9 to 34.9]) and among men, manufacture of motor vehicle bodies (OR, 5.2; 95% CI, 1.2 to 22.4), footwear (OR, 3.9: 95% CI, 0.9 to 16.1), and metal structures (OR, 3.3; 95% CI, 1.0 to 10.4). The identified high-risk occupations with all OR above 2 were shoemakers, structural metal preparers, construction painters and other construction workers. bookkeepers, machine fitters, and welders (men). The OR for regular occupational use of organic. solvents for at least half a year was 2.0 (95% CI, 1.0 to 4.2). Exposure to rust-preventive paint containing lead was suggested as another potential occupational exposure (OR, 9.1; 95% CI, 0.8 to 107). This explorative study suggests an association between certain occupational exposures and SBC, bill some of these associations could be attributable to chance. All findings should be regarded as tentative. (Less)
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Journal of Occupational and Environmental Medicine
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44
issue
6
pages
516 - 522
publisher
Lippincott Williams & Wilkins
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  • pmid:12085477
  • wos:000176267200012
  • scopus:18544383955
ISSN
1536-5948
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English
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yes
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5a3b9df9-5f93-44a9-9bbd-f8e824ab6da0 (old id 909846)
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http://www.joem.org/pt/re/joem/abstract.00043764-200206000-00012.htm
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2008-01-23 11:21:16
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2017-01-15 04:17:44
@article{5a3b9df9-5f93-44a9-9bbd-f8e824ab6da0,
  abstract     = {Small bowel carcinoid tumor (SBC) is a rare disease of unknown etiology bill with all age-, sex-, and place-specific occurrence that may indicate an occupational origin. A European multicenter population-based case-control study was conducted from 1995 through 1997. Incident SBC cases between 35 and 69 years of age (n = 101) were identified, together with 3335 controls sampled from the catchment area of the cases. Histological review performed by a reference pathologist left 99 cases for study; 84 cases and 2070 population controls were interviewed. The industries most closely associated (a twofold or more odds ratio [OR]) with SBC taking into account a 10-year time lag after exposure were, among women, employment in wholesale industry of food and beverages (OR, 8.2; 95% confidence interval [CI], [1.9 to 34.9]) and among men, manufacture of motor vehicle bodies (OR, 5.2; 95% CI, 1.2 to 22.4), footwear (OR, 3.9: 95% CI, 0.9 to 16.1), and metal structures (OR, 3.3; 95% CI, 1.0 to 10.4). The identified high-risk occupations with all OR above 2 were shoemakers, structural metal preparers, construction painters and other construction workers. bookkeepers, machine fitters, and welders (men). The OR for regular occupational use of organic. solvents for at least half a year was 2.0 (95% CI, 1.0 to 4.2). Exposure to rust-preventive paint containing lead was suggested as another potential occupational exposure (OR, 9.1; 95% CI, 0.8 to 107). This explorative study suggests an association between certain occupational exposures and SBC, bill some of these associations could be attributable to chance. All findings should be regarded as tentative.},
  author       = {Kaerlev, L and Teglbjaerg, PS and Sabroe, S and Kolstad, HA and Ahrens, W and Eriksson, Mikael and Guenel, P and Hardell, L and Cyr, D and Ballard, T and Zambon, P and Suarez-Varela, MMM and Stang, A and Olsen, J},
  issn         = {1536-5948},
  language     = {eng},
  number       = {6},
  pages        = {516--522},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Journal of Occupational and Environmental Medicine},
  title        = {Occupational risk factors for small bowel carcinoid tumor: A European population-based case-control study},
  volume       = {44},
  year         = {2002},
}