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Tau haplotypes support the Asian ancestry of the Roma population settled in the Basque Country

Alfonso-Sánchez, Miguel A.; Espinosa, Ibone; Gómez-Pérez, Luis; Poveda, Alaitz LU ; Rebato, Esther and Peña, Jose A. (2018) In Heredity 120. p.91-99
Abstract

We examined tau haplotype frequencies in two different ethnical groups from the Basque Country (BC): Roma people and residents of European ancestry (general population). In addition, we analyzed the spatial distribution of tau haplotypes in Eurasian populations to explore the genetic affinities of the Romani groups living in Europe in a broader scope. The 17q21.31 genomic region was characterized through the genotyping of two diagnostic single nucleotide polymorphisms, SNPs (rs10514879 and rs199451), which allow the identification of H1 and H2 haplotypes. A significant heterozygous deficit was detected in the Romani for rs10514879. The H2 haplotype frequency proved to be more than twice in the BC general population (0.283) than in the... (More)

We examined tau haplotype frequencies in two different ethnical groups from the Basque Country (BC): Roma people and residents of European ancestry (general population). In addition, we analyzed the spatial distribution of tau haplotypes in Eurasian populations to explore the genetic affinities of the Romani groups living in Europe in a broader scope. The 17q21.31 genomic region was characterized through the genotyping of two diagnostic single nucleotide polymorphisms, SNPs (rs10514879 and rs199451), which allow the identification of H1 and H2 haplotypes. A significant heterozygous deficit was detected in the Romani for rs10514879. The H2 haplotype frequency proved to be more than twice in the BC general population (0.283) than in the Roma people (0.127). In contrast, H2 frequency proved to be very similar between Basque and Hungarian Romani, and similar to the H2 frequencies found in northwestern India and Pakistan as well. Several statistical analyses unveiled genetic structuring for the MAPT diversity, mirrored in a significant association between geography and genetic distances, with an upward trend of H2 haplotype frequencies from Asia to Europe. Yet, Roma samples did not fit into this general spatial patterning because of their discrepancy between geographical position and H2 frequency. Despite the long spatial coexistence in the Basque region between the residents of European ancestry and the Roma, the latter have preserved their Asian genetic ancestry. Bearing in mind the lack of geographical barriers between both ethnical groups, these findings support the notion that sociocultural mores might promote assortative matings in human populations.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Heredity
volume
120
pages
91 - 99
publisher
Macmillan
external identifiers
  • scopus:85037660512
ISSN
0018-067X
DOI
10.1038/s41437-017-0001-x
language
English
LU publication?
yes
id
909cd6b7-1793-4ae1-adfe-93255394bfd0
date added to LUP
2018-01-04 12:25:05
date last changed
2018-04-06 03:00:08
@article{909cd6b7-1793-4ae1-adfe-93255394bfd0,
  abstract     = {<p>We examined tau haplotype frequencies in two different ethnical groups from the Basque Country (BC): Roma people and residents of European ancestry (general population). In addition, we analyzed the spatial distribution of tau haplotypes in Eurasian populations to explore the genetic affinities of the Romani groups living in Europe in a broader scope. The 17q21.31 genomic region was characterized through the genotyping of two diagnostic single nucleotide polymorphisms, SNPs (rs10514879 and rs199451), which allow the identification of H1 and H2 haplotypes. A significant heterozygous deficit was detected in the Romani for rs10514879. The H2 haplotype frequency proved to be more than twice in the BC general population (0.283) than in the Roma people (0.127). In contrast, H2 frequency proved to be very similar between Basque and Hungarian Romani, and similar to the H2 frequencies found in northwestern India and Pakistan as well. Several statistical analyses unveiled genetic structuring for the MAPT diversity, mirrored in a significant association between geography and genetic distances, with an upward trend of H2 haplotype frequencies from Asia to Europe. Yet, Roma samples did not fit into this general spatial patterning because of their discrepancy between geographical position and H2 frequency. Despite the long spatial coexistence in the Basque region between the residents of European ancestry and the Roma, the latter have preserved their Asian genetic ancestry. Bearing in mind the lack of geographical barriers between both ethnical groups, these findings support the notion that sociocultural mores might promote assortative matings in human populations.</p>},
  author       = {Alfonso-Sánchez, Miguel A. and Espinosa, Ibone and Gómez-Pérez, Luis and Poveda, Alaitz and Rebato, Esther and Peña, Jose A.},
  issn         = {0018-067X},
  language     = {eng},
  pages        = {91--99},
  publisher    = {Macmillan},
  series       = {Heredity},
  title        = {Tau haplotypes support the Asian ancestry of the Roma population settled in the Basque Country},
  url          = {http://dx.doi.org/10.1038/s41437-017-0001-x},
  volume       = {120},
  year         = {2018},
}