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How it all began : Cancer cytogenetics before sequencing

Mitelman, Felix LU and Heim, Sverre LU (2015) In Cancer Cytogenetics p.1-10
Abstract

According to Boveri's hypothesis, chromosome abnormalities were the cellular changes causing the transition from normal to malignant proliferation. Technical difficulties prevented reliable visualization of mammalian chromosomes, in both normal and neoplastic cells, throughout the entire first half of the 20th century. Nowell and Hungerford's discovery greatly stimulated interest in cancer cytogenetics in the early 1960s, but for several reasons, the Ph chromosome long remained an exceptional finding. The advent of molecular genetics in the 1980s and the development of a range of powerful molecular cytogenetic technologies, such as fluorescence in situ hybridization (FISH), multicolor FISH, comparative genomic hybridization (CGH),... (More)

According to Boveri's hypothesis, chromosome abnormalities were the cellular changes causing the transition from normal to malignant proliferation. Technical difficulties prevented reliable visualization of mammalian chromosomes, in both normal and neoplastic cells, throughout the entire first half of the 20th century. Nowell and Hungerford's discovery greatly stimulated interest in cancer cytogenetics in the early 1960s, but for several reasons, the Ph chromosome long remained an exceptional finding. The advent of molecular genetics in the 1980s and the development of a range of powerful molecular cytogenetic technologies, such as fluorescence in situ hybridization (FISH), multicolor FISH, comparative genomic hybridization (CGH), various array-based genotyping technologies, and DNA and RNA sequencing, have widened one's knowledge and understanding of the molecular mechanisms that are operative in neoplastic initiation and progression. In the 100 years since Boveri first postulated that chromosome change may initiate the carcinogenic process, cancer cytogenetics has come of age.

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author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Cancer cytogenetics, Carcinoma, Genomic hybridization, Malignant tumor, Molecular genetics, Neoplasia, Ph chromosome, RNA sequencing, Theodor Boveri
in
Cancer Cytogenetics
editor
Heim, Sverre; Mitelman, Felix; and
pages
10 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:85015857598
ISBN
9781118795538
9781118795569
DOI
10.1002/9781118795569.ch1
language
English
LU publication?
yes
id
90e1eee7-5ec5-43c7-ab59-0cbe4299a818
date added to LUP
2017-04-20 10:57:22
date last changed
2017-04-20 10:57:22
@inbook{90e1eee7-5ec5-43c7-ab59-0cbe4299a818,
  abstract     = {<p>According to Boveri's hypothesis, chromosome abnormalities were the cellular changes causing the transition from normal to malignant proliferation. Technical difficulties prevented reliable visualization of mammalian chromosomes, in both normal and neoplastic cells, throughout the entire first half of the 20th century. Nowell and Hungerford's discovery greatly stimulated interest in cancer cytogenetics in the early 1960s, but for several reasons, the Ph chromosome long remained an exceptional finding. The advent of molecular genetics in the 1980s and the development of a range of powerful molecular cytogenetic technologies, such as fluorescence in situ hybridization (FISH), multicolor FISH, comparative genomic hybridization (CGH), various array-based genotyping technologies, and DNA and RNA sequencing, have widened one's knowledge and understanding of the molecular mechanisms that are operative in neoplastic initiation and progression. In the 100 years since Boveri first postulated that chromosome change may initiate the carcinogenic process, cancer cytogenetics has come of age.</p>},
  author       = {Mitelman, Felix and Heim, Sverre},
  editor       = {Heim, Sverre and Mitelman, Felix},
  isbn         = {9781118795538},
  keyword      = {Cancer cytogenetics,Carcinoma,Genomic hybridization,Malignant tumor,Molecular genetics,Neoplasia,Ph chromosome,RNA sequencing,Theodor Boveri},
  language     = {eng},
  month        = {06},
  pages        = {1--10},
  publisher    = {Wiley-Blackwell},
  series       = {Cancer Cytogenetics},
  title        = {How it all began : Cancer cytogenetics before sequencing},
  url          = {http://dx.doi.org/10.1002/9781118795569.ch1},
  year         = {2015},
}