Older patients with acute myeloid leukemia benefit from intensive chemotherapy: an update from the Swedish acute leukemia registry.
(2011) In Clinical Lymphoma, Myeloma & Leukemia 11 Suppl 1. p.54-59- Abstract
- Most patients with acute myeloid leukemia (AML) are older, the median age is 71 years, and survival decreases rapidly with age. The achievement of complete remission and long-term survival mostly require intensive combination chemotherapy, but standard regimens are often believed to be too toxic for older patients. The Swedish Acute Leukemia Registry is unique and contains data on 98% of all patients diagnosed since 1997, irrespective of management. Comorbidity increases with age, but the distribution of AML-related risk factors is mostly similar in different age groups of patients older than 60 years old. In Sweden, most patients up to 75 years old are given intensive induction treatment with acceptable complete remission rates. Early... (More)
- Most patients with acute myeloid leukemia (AML) are older, the median age is 71 years, and survival decreases rapidly with age. The achievement of complete remission and long-term survival mostly require intensive combination chemotherapy, but standard regimens are often believed to be too toxic for older patients. The Swedish Acute Leukemia Registry is unique and contains data on 98% of all patients diagnosed since 1997, irrespective of management. Comorbidity increases with age, but the distribution of AML-related risk factors is mostly similar in different age groups of patients older than 60 years old. In Sweden, most patients up to 75 years old are given intensive induction treatment with acceptable complete remission rates. Early death rates were always lower with intensive treatment compared with palliative treatment, thus, most patients up to 75 years and with AML both tolerate and benefit from intensive induction treatment. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2221070
- author
- Juliusson, Gunnar LU
- organization
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Clinical Lymphoma, Myeloma & Leukemia
- volume
- 11 Suppl 1
- pages
- 54 - 59
- publisher
- CIG Media Group
- external identifiers
-
- pmid:22035749
- scopus:84860329358
- pmid:22035749
- ISSN
- 2152-2650
- DOI
- 10.1016/j.clml.2011.02.003
- language
- English
- LU publication?
- yes
- id
- 910cf888-ba07-4bc3-ab2d-2fd8563321b6 (old id 2221070)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22035749?dopt=Abstract
- date added to LUP
- 2016-04-04 07:17:30
- date last changed
- 2022-08-15 19:25:51
@article{910cf888-ba07-4bc3-ab2d-2fd8563321b6,
abstract = {{Most patients with acute myeloid leukemia (AML) are older, the median age is 71 years, and survival decreases rapidly with age. The achievement of complete remission and long-term survival mostly require intensive combination chemotherapy, but standard regimens are often believed to be too toxic for older patients. The Swedish Acute Leukemia Registry is unique and contains data on 98% of all patients diagnosed since 1997, irrespective of management. Comorbidity increases with age, but the distribution of AML-related risk factors is mostly similar in different age groups of patients older than 60 years old. In Sweden, most patients up to 75 years old are given intensive induction treatment with acceptable complete remission rates. Early death rates were always lower with intensive treatment compared with palliative treatment, thus, most patients up to 75 years and with AML both tolerate and benefit from intensive induction treatment.}},
author = {{Juliusson, Gunnar}},
issn = {{2152-2650}},
language = {{eng}},
pages = {{54--59}},
publisher = {{CIG Media Group}},
series = {{Clinical Lymphoma, Myeloma & Leukemia}},
title = {{Older patients with acute myeloid leukemia benefit from intensive chemotherapy: an update from the Swedish acute leukemia registry.}},
url = {{http://dx.doi.org/10.1016/j.clml.2011.02.003}},
doi = {{10.1016/j.clml.2011.02.003}},
volume = {{11 Suppl 1}},
year = {{2011}},
}