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Hypertension and Reproduction

Nilsson, Peter M. LU ; Viigimaa, Margus ; Giwercman, Aleksander LU and Cifkova, Renata (2020) In Current Hypertension Reports 22(4).
Abstract

Purpose of Review: Many aspects of reproduction have been associated with increased blood pressure and impaired glucose metabolism that reveals a subsequent increased risk of cardiovascular disease. The aim of this review is to assess reproductive life factors associated with an increased risk of hypertension and cardiovascular disease, e.g., early life programming, sexual, and reproductive health in men and women. Recent Findings: Impaired fetal growth, with low birth weight adjusted for gestational age, has been found associated with hypertension in adulthood. Erectile dysfunction, currently considered an early diagnostic marker of cardiovascular disease preceding the manifestation of coronary artery disease by several years,... (More)

Purpose of Review: Many aspects of reproduction have been associated with increased blood pressure and impaired glucose metabolism that reveals a subsequent increased risk of cardiovascular disease. The aim of this review is to assess reproductive life factors associated with an increased risk of hypertension and cardiovascular disease, e.g., early life programming, sexual, and reproductive health in men and women. Recent Findings: Impaired fetal growth, with low birth weight adjusted for gestational age, has been found associated with hypertension in adulthood. Erectile dysfunction, currently considered an early diagnostic marker of cardiovascular disease preceding the manifestation of coronary artery disease by several years, frequently coexisting with hypertension, could also be exacerbated by some antihypertensive drugs. Male hypogonadism or subfertility are associated with increased cardiovascular risk. Hypertensive disorders in pregnancy including preeclampsia represent a major cause of maternal, fetal and neonatal morbidity, and mortality. The risk of developing preeclampsia can be substantially reduced in women at its high or moderate risk with a low dose of acetylsalicylic acid initiated from 12 weeks of gestation. An increased risk of hypertension in women following invasive-assisted reproductive technologies has been newly observed. Blood pressure elevation has been noticed following contraceptive pill use, around the menopause and in postmenopausal age. Furthermore, drug treatment of hypertension has to be considered as a factor with a potential impact on reproduction (e.g., due to teratogenic drug effects). Summary: In summary, a deeper understanding of reproductive life effects on hypertension and metabolic abnormalities may improve prediction of future cardiovascular disease.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Assisted reproductive technologies, Erectile dysfunction, Hypertensive disorders in pregnancy, Low birth weight, Male hypogonadism, Oral contraception
in
Current Hypertension Reports
volume
22
issue
4
article number
29
publisher
Current Medicine Group LLC
external identifiers
  • pmid:32170412
  • scopus:85081579084
ISSN
1522-6417
DOI
10.1007/s11906-020-01036-2
language
English
LU publication?
yes
id
9125192f-cfd6-423f-b10b-ff42bb5e4a34
date added to LUP
2020-03-30 16:46:04
date last changed
2020-10-20 03:04:58
@article{9125192f-cfd6-423f-b10b-ff42bb5e4a34,
  abstract     = {<p>Purpose of Review: Many aspects of reproduction have been associated with increased blood pressure and impaired glucose metabolism that reveals a subsequent increased risk of cardiovascular disease. The aim of this review is to assess reproductive life factors associated with an increased risk of hypertension and cardiovascular disease, e.g., early life programming, sexual, and reproductive health in men and women. Recent Findings: Impaired fetal growth, with low birth weight adjusted for gestational age, has been found associated with hypertension in adulthood. Erectile dysfunction, currently considered an early diagnostic marker of cardiovascular disease preceding the manifestation of coronary artery disease by several years, frequently coexisting with hypertension, could also be exacerbated by some antihypertensive drugs. Male hypogonadism or subfertility are associated with increased cardiovascular risk. Hypertensive disorders in pregnancy including preeclampsia represent a major cause of maternal, fetal and neonatal morbidity, and mortality. The risk of developing preeclampsia can be substantially reduced in women at its high or moderate risk with a low dose of acetylsalicylic acid initiated from 12 weeks of gestation. An increased risk of hypertension in women following invasive-assisted reproductive technologies has been newly observed. Blood pressure elevation has been noticed following contraceptive pill use, around the menopause and in postmenopausal age. Furthermore, drug treatment of hypertension has to be considered as a factor with a potential impact on reproduction (e.g., due to teratogenic drug effects). Summary: In summary, a deeper understanding of reproductive life effects on hypertension and metabolic abnormalities may improve prediction of future cardiovascular disease.</p>},
  author       = {Nilsson, Peter M. and Viigimaa, Margus and Giwercman, Aleksander and Cifkova, Renata},
  issn         = {1522-6417},
  language     = {eng},
  month        = {03},
  number       = {4},
  publisher    = {Current Medicine Group LLC},
  series       = {Current Hypertension Reports},
  title        = {Hypertension and Reproduction},
  url          = {http://dx.doi.org/10.1007/s11906-020-01036-2},
  doi          = {10.1007/s11906-020-01036-2},
  volume       = {22},
  year         = {2020},
}