An international multicentre study on the allergenic activity of air-oxidized R-limonene.
(2013) In Contact Dermatitis 68(4). p.214-223- Abstract
- Background. Limonene is a common fragrance terpene that, in its pure form, is not allergenic or is a very weak allergen. However, limonene autoxidizes on air exposure, and the oxidation products can cause contact allergy. Oxidized R-limonene has previously been patch tested in multicentre studies, giving 2-3% positive patch test reactions in consecutive patients. Objectives. To investigate whether oxidized R-limonene 3.0% in petrolatum, with a stable concentration of the main haptens, limonene hydroperoxides (Lim-OOHs), could be a useful tool for the detection of contact allergy in an international setting. Methods. Oxidized R-limonene 3.0% (Lim-OOHs 0.33%) pet. was tested in 2900 consecutive dermatitis patients in Denmark, the United... (More)
- Background. Limonene is a common fragrance terpene that, in its pure form, is not allergenic or is a very weak allergen. However, limonene autoxidizes on air exposure, and the oxidation products can cause contact allergy. Oxidized R-limonene has previously been patch tested in multicentre studies, giving 2-3% positive patch test reactions in consecutive patients. Objectives. To investigate whether oxidized R-limonene 3.0% in petrolatum, with a stable concentration of the main haptens, limonene hydroperoxides (Lim-OOHs), could be a useful tool for the detection of contact allergy in an international setting. Methods. Oxidized R-limonene 3.0% (Lim-OOHs 0.33%) pet. was tested in 2900 consecutive dermatitis patients in Denmark, the United Kingdom, Singapore, Spain, Sweden, and Australia. Results. Overall, 5.2% (range 2.3-12.1%) of the patients showed a positive patch test reaction to oxidized R-limonene. Doubtful reactions were found in 7.0% of the patients (range 0-24%). Few irritant reactions were seen. Conclusions. Oxidized R-limonene at 3.0% pet. with a specified content of Lim-OOHs 0.33% is a standardized and useful tool for the detection of contact allergy in dermatitis patients. Many patients showing positive patch test reactions to oxidized R-limonene would not be informed of their fragrance allergy if this specific test had not been performed. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3627963
- author
- Bråred Christensson, Johanna ; Andersen, Klaus E ; Bruze, Magnus LU ; Johansen, Jeanne D ; Garcia-Bravo, Begoña ; Giménez-Arnau, Ana ; Goh, Chee-Leok ; Nixon, Rosemary and White, Ian R
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Contact Dermatitis
- volume
- 68
- issue
- 4
- pages
- 214 - 223
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000316630900003
- pmid:23510342
- scopus:84875331075
- pmid:23510342
- ISSN
- 0105-1873
- DOI
- 10.1111/cod.12036
- language
- English
- LU publication?
- yes
- id
- 914651b9-e3d4-4ffc-a6a7-e57d16311222 (old id 3627963)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23510342?dopt=Abstract
- date added to LUP
- 2016-04-01 10:31:51
- date last changed
- 2022-06-22 20:17:52
@article{914651b9-e3d4-4ffc-a6a7-e57d16311222,
abstract = {{Background. Limonene is a common fragrance terpene that, in its pure form, is not allergenic or is a very weak allergen. However, limonene autoxidizes on air exposure, and the oxidation products can cause contact allergy. Oxidized R-limonene has previously been patch tested in multicentre studies, giving 2-3% positive patch test reactions in consecutive patients. Objectives. To investigate whether oxidized R-limonene 3.0% in petrolatum, with a stable concentration of the main haptens, limonene hydroperoxides (Lim-OOHs), could be a useful tool for the detection of contact allergy in an international setting. Methods. Oxidized R-limonene 3.0% (Lim-OOHs 0.33%) pet. was tested in 2900 consecutive dermatitis patients in Denmark, the United Kingdom, Singapore, Spain, Sweden, and Australia. Results. Overall, 5.2% (range 2.3-12.1%) of the patients showed a positive patch test reaction to oxidized R-limonene. Doubtful reactions were found in 7.0% of the patients (range 0-24%). Few irritant reactions were seen. Conclusions. Oxidized R-limonene at 3.0% pet. with a specified content of Lim-OOHs 0.33% is a standardized and useful tool for the detection of contact allergy in dermatitis patients. Many patients showing positive patch test reactions to oxidized R-limonene would not be informed of their fragrance allergy if this specific test had not been performed.}},
author = {{Bråred Christensson, Johanna and Andersen, Klaus E and Bruze, Magnus and Johansen, Jeanne D and Garcia-Bravo, Begoña and Giménez-Arnau, Ana and Goh, Chee-Leok and Nixon, Rosemary and White, Ian R}},
issn = {{0105-1873}},
language = {{eng}},
number = {{4}},
pages = {{214--223}},
publisher = {{Wiley-Blackwell}},
series = {{Contact Dermatitis}},
title = {{An international multicentre study on the allergenic activity of air-oxidized R-limonene.}},
url = {{http://dx.doi.org/10.1111/cod.12036}},
doi = {{10.1111/cod.12036}},
volume = {{68}},
year = {{2013}},
}