Outpatient prescription of pulmonary vasodilator therapy to preterm children with bronchopulmonary dysplasia
Jeremiasen, Ida LU ; Tran-Lundmark, Karin LU ; Dolk, Mikaela LU
and Naumburg, Estelle
(2023)
In Acta Paediatrica, International Journal of Paediatrics
112(3).
p.409-416
- Abstract
Aim: The use of pulmonary vasodilator therapy in children born preterm is largely unknown. Our aim was to map prescription patterns in children with bronchopulmonary dysplasia in Sweden. Methods: This was a descriptive national registry-based study of children <7 years who had been prescribed a pulmonary vasodilator during 2007–2017, were born preterm and classified as having bronchopulmonary dysplasia. Information on prescriptions, patient characteristics and comorbidities were retrieved from the Swedish Prescribed Drug Register and linked to other national registers. Results: The study included 74 children, 54 (73%) born at 22–27 weeks' gestation and 20 (27%) at 28–36 weeks. Single therapy was most common, n = 64 (86.5%), and... (More)
Aim: The use of pulmonary vasodilator therapy in children born preterm is largely unknown. Our aim was to map prescription patterns in children with bronchopulmonary dysplasia in Sweden. Methods: This was a descriptive national registry-based study of children <7 years who had been prescribed a pulmonary vasodilator during 2007–2017, were born preterm and classified as having bronchopulmonary dysplasia. Information on prescriptions, patient characteristics and comorbidities were retrieved from the Swedish Prescribed Drug Register and linked to other national registers. Results: The study included 74 children, 54 (73%) born at 22–27 weeks' gestation and 20 (27%) at 28–36 weeks. Single therapy was most common, n = 64 (86.5%), and sildenafil was prescribed most frequently, n = 69 (93%). Bosentan, iloprost, macitentan and/or treprostinil were used mainly for combination therapies, n = 10 (13.5%). Patent ductus arteriosus or atrial septal defect were present in 29 (39%) and 25 (34%) children, respectively, and 20 (69%) versus 3 (12%) underwent closure. Cardiac catheterisation was performed in 19 (26%) patients. Median duration of therapy was 4.6 (1.9-6.8, 95% CI) months. Mortality was 9%. Conclusion: Preterm children with bronchopulmonary dysplasia were prescribed pulmonary vasodilators, often without prior catheterisation. Sildenafil was most commonly used. Diagnostic tools, effects, and drug safety need further evaluation.
(Less)
- author
- Jeremiasen, Ida
LU
; Tran-Lundmark, Karin
LU
; Dolk, Mikaela
LU
and Naumburg, Estelle
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- bronchopulmonary dysplasia, national survey, preterm children, pulmonary hypertension, therapy
- in
- Acta Paediatrica, International Journal of Paediatrics
- volume
- 112
- issue
- 3
- pages
- 409 - 416
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:36478302
- scopus:85144229816
- ISSN
- 0803-5253
- DOI
- 10.1111/apa.16615
- language
- English
- LU publication?
- yes
- id
- 9163b6bd-3a9e-4e26-8495-66243d3a090e
- date added to LUP
- 2023-01-23 15:29:34
- date last changed
- 2024-04-16 12:14:28
@article{9163b6bd-3a9e-4e26-8495-66243d3a090e,
abstract = {{<p>Aim: The use of pulmonary vasodilator therapy in children born preterm is largely unknown. Our aim was to map prescription patterns in children with bronchopulmonary dysplasia in Sweden. Methods: This was a descriptive national registry-based study of children <7 years who had been prescribed a pulmonary vasodilator during 2007–2017, were born preterm and classified as having bronchopulmonary dysplasia. Information on prescriptions, patient characteristics and comorbidities were retrieved from the Swedish Prescribed Drug Register and linked to other national registers. Results: The study included 74 children, 54 (73%) born at 22–27 weeks' gestation and 20 (27%) at 28–36 weeks. Single therapy was most common, n = 64 (86.5%), and sildenafil was prescribed most frequently, n = 69 (93%). Bosentan, iloprost, macitentan and/or treprostinil were used mainly for combination therapies, n = 10 (13.5%). Patent ductus arteriosus or atrial septal defect were present in 29 (39%) and 25 (34%) children, respectively, and 20 (69%) versus 3 (12%) underwent closure. Cardiac catheterisation was performed in 19 (26%) patients. Median duration of therapy was 4.6 (1.9-6.8, 95% CI) months. Mortality was 9%. Conclusion: Preterm children with bronchopulmonary dysplasia were prescribed pulmonary vasodilators, often without prior catheterisation. Sildenafil was most commonly used. Diagnostic tools, effects, and drug safety need further evaluation.</p>}},
author = {{Jeremiasen, Ida and Tran-Lundmark, Karin and Dolk, Mikaela and Naumburg, Estelle}},
issn = {{0803-5253}},
keywords = {{bronchopulmonary dysplasia; national survey; preterm children; pulmonary hypertension; therapy}},
language = {{eng}},
number = {{3}},
pages = {{409--416}},
publisher = {{Wiley-Blackwell}},
series = {{Acta Paediatrica, International Journal of Paediatrics}},
title = {{Outpatient prescription of pulmonary vasodilator therapy to preterm children with bronchopulmonary dysplasia}},
url = {{http://dx.doi.org/10.1111/apa.16615}},
doi = {{10.1111/apa.16615}},
volume = {{112}},
year = {{2023}},
}