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Carbon dioxide narcosis : Influence of short-term high concentration carbon dioxide inhalation on EEG and cortical evoked responses in the rat

Forslid, A. LU orcid ; Ingvar, Martin ; Rosen, I. LU and Ingvar, D H (1986) In Acta Physiologica Scandinavica 127(3). p.281-287
Abstract

The effects of 1 min exposure to 80% CO2 inhalation was studied in rats under light general anaesthesia with N2O. It was found that 80% CO2 gave a rapid slowing of the EEG as well as a rapid decrease of the amplitude of cortical somatosensory evoked potentials. Only minor influences upon the blood pressure and heart rate were seen. The changes were found to be transient and most of the EEG effects had disappeared about 2-3 min following the end of the CO2 exposure. The findings are related to current procedures for preslaughter anaesthesia in swine using 80% CO2. The present experiments show that 80% CO2 rapidly induces an interruption of afferent sensory transmission to... (More)

The effects of 1 min exposure to 80% CO2 inhalation was studied in rats under light general anaesthesia with N2O. It was found that 80% CO2 gave a rapid slowing of the EEG as well as a rapid decrease of the amplitude of cortical somatosensory evoked potentials. Only minor influences upon the blood pressure and heart rate were seen. The changes were found to be transient and most of the EEG effects had disappeared about 2-3 min following the end of the CO2 exposure. The findings are related to current procedures for preslaughter anaesthesia in swine using 80% CO2. The present experiments show that 80% CO2 rapidly induces an interruption of afferent sensory transmission to the cortex as well as slowing of the EEG. Both findings indicate that 80% CO2 is an effective agent for inducing adequate anaesthesia for slaughter procedures. However, the transient nature of the CO2 effects upon the central nervous system revealed here has to be taken into account to optimize the slaughter house procedures.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Physiologica Scandinavica
volume
127
issue
3
pages
281 - 287
publisher
Wiley-Blackwell
external identifiers
  • pmid:3092576
  • scopus:0022446114
ISSN
0001-6772
DOI
10.1111/j.1748-1716.1986.tb07907.x
language
English
LU publication?
yes
id
9180207f-119e-4319-bc6f-54c558829f8d
date added to LUP
2017-02-03 08:51:24
date last changed
2025-01-07 05:52:06
@article{9180207f-119e-4319-bc6f-54c558829f8d,
  abstract     = {{<p>The effects of 1 min exposure to 80% CO<sub>2</sub> inhalation was studied in rats under light general anaesthesia with N<sub>2</sub>O. It was found that 80% CO<sub>2</sub> gave a rapid slowing of the EEG as well as a rapid decrease of the amplitude of cortical somatosensory evoked potentials. Only minor influences upon the blood pressure and heart rate were seen. The changes were found to be transient and most of the EEG effects had disappeared about 2-3 min following the end of the CO<sub>2</sub> exposure. The findings are related to current procedures for preslaughter anaesthesia in swine using 80% CO<sub>2</sub>. The present experiments show that 80% CO<sub>2</sub> rapidly induces an interruption of afferent sensory transmission to the cortex as well as slowing of the EEG. Both findings indicate that 80% CO<sub>2</sub> is an effective agent for inducing adequate anaesthesia for slaughter procedures. However, the transient nature of the CO<sub>2</sub> effects upon the central nervous system revealed here has to be taken into account to optimize the slaughter house procedures.</p>}},
  author       = {{Forslid, A. and Ingvar, Martin and Rosen, I. and Ingvar, D H}},
  issn         = {{0001-6772}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{281--287}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Acta Physiologica Scandinavica}},
  title        = {{Carbon dioxide narcosis : Influence of short-term high concentration carbon dioxide inhalation on EEG and cortical evoked responses in the rat}},
  url          = {{http://dx.doi.org/10.1111/j.1748-1716.1986.tb07907.x}},
  doi          = {{10.1111/j.1748-1716.1986.tb07907.x}},
  volume       = {{127}},
  year         = {{1986}},
}