Advanced

The effects of TTS-scopolamine, dimenhydrinate, lidocaine, and tocainide on motion sickness, vertigo, and nystagmus

Pyykkö, I.; Padoan, S; Schalén, L LU ; Lyttkens, Linda; Magnusson, M LU and Henriksson, N.G. (1985) In Aviation Space and Environmental Medicine 56(8). p.82-777
Abstract

The effects of TTS-scopolamine, dimenhydrinate, lidocaine, and tocainide on motion sickness and vertigo and on caloric and postrotatory nystagmus were evaluated in healthy volunteers. TTS-scopolamine was administered transdermally (delivering approximately 10 micrograms X h-1 scopolamine base) and 100 mg dimenhydrinate orally. Lidocaine and tocainide were administered intravenously (average plasma concentration of lidocaine 6 mol X L-1 and of tocainide 20 mol X L-1). TTS-scopolamine and dimenhydrinate significantly reduced vertigo induced by calorization of the ears, nausea provoked with Coriolis maneuvre, and nystagmus in caloric and rotatory tests. During treatment with lidocaine and tocainide no alleviation of vertigo and nausea was... (More)

The effects of TTS-scopolamine, dimenhydrinate, lidocaine, and tocainide on motion sickness and vertigo and on caloric and postrotatory nystagmus were evaluated in healthy volunteers. TTS-scopolamine was administered transdermally (delivering approximately 10 micrograms X h-1 scopolamine base) and 100 mg dimenhydrinate orally. Lidocaine and tocainide were administered intravenously (average plasma concentration of lidocaine 6 mol X L-1 and of tocainide 20 mol X L-1). TTS-scopolamine and dimenhydrinate significantly reduced vertigo induced by calorization of the ears, nausea provoked with Coriolis maneuvre, and nystagmus in caloric and rotatory tests. During treatment with lidocaine and tocainide no alleviation of vertigo and nausea was observed. Caloric nystagmus was reduced but rotation induced nystagmus was virtually unchanged. Presumably the motion sickness drugs act at the brain stem where TTS-scopolamine and dimenhydrinate have their target cells in the vestibular nuclei. Furthermore, the alleviation of motion sickness was linked to a decline of nystagmus. Lidocaine and tocainide, the action of which in vertigo and nausea in patients is proposed to be on the vestibular end organs and the supratentorial brain structures, consistently failed to alleviate motion sickness.

(Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
keywords
Administration, Topical, Adult, Caloric Tests, Dimenhydrinate, Humans, Infusions, Parenteral, Lidocaine, Motion Sickness, Nausea, Nystagmus, Physiologic, Scopolamine Hydrobromide, Tocainide, Vertigo, Comparative Study, Journal Article
in
Aviation Space and Environmental Medicine
volume
56
issue
8
pages
82 - 777
publisher
Aerospace Medical Association
external identifiers
  • scopus:0022257843
ISSN
0095-6562
language
English
LU publication?
yes
id
918f049d-4ca4-475e-9d81-5c817cac84fe
date added to LUP
2017-05-03 13:07:57
date last changed
2017-09-03 05:21:47
@article{918f049d-4ca4-475e-9d81-5c817cac84fe,
  abstract     = {<p>The effects of TTS-scopolamine, dimenhydrinate, lidocaine, and tocainide on motion sickness and vertigo and on caloric and postrotatory nystagmus were evaluated in healthy volunteers. TTS-scopolamine was administered transdermally (delivering approximately 10 micrograms X h-1 scopolamine base) and 100 mg dimenhydrinate orally. Lidocaine and tocainide were administered intravenously (average plasma concentration of lidocaine 6 mol X L-1 and of tocainide 20 mol X L-1). TTS-scopolamine and dimenhydrinate significantly reduced vertigo induced by calorization of the ears, nausea provoked with Coriolis maneuvre, and nystagmus in caloric and rotatory tests. During treatment with lidocaine and tocainide no alleviation of vertigo and nausea was observed. Caloric nystagmus was reduced but rotation induced nystagmus was virtually unchanged. Presumably the motion sickness drugs act at the brain stem where TTS-scopolamine and dimenhydrinate have their target cells in the vestibular nuclei. Furthermore, the alleviation of motion sickness was linked to a decline of nystagmus. Lidocaine and tocainide, the action of which in vertigo and nausea in patients is proposed to be on the vestibular end organs and the supratentorial brain structures, consistently failed to alleviate motion sickness.</p>},
  author       = {Pyykkö, I. and Padoan, S and Schalén, L and Lyttkens, Linda and Magnusson, M and Henriksson, N.G.},
  issn         = {0095-6562},
  keyword      = {Administration, Topical,Adult,Caloric Tests,Dimenhydrinate,Humans,Infusions, Parenteral,Lidocaine,Motion Sickness,Nausea,Nystagmus, Physiologic,Scopolamine Hydrobromide,Tocainide,Vertigo,Comparative Study,Journal Article},
  language     = {eng},
  number       = {8},
  pages        = {82--777},
  publisher    = {Aerospace Medical Association},
  series       = {Aviation Space and Environmental Medicine},
  title        = {The effects of TTS-scopolamine, dimenhydrinate, lidocaine, and tocainide on motion sickness, vertigo, and nystagmus},
  volume       = {56},
  year         = {1985},
}