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Thyroid Hormones in the Brain and Their Impact in Recovery Mechanisms After Stroke

Talhada, Daniela LU ; Santos, Cecília Reis Alves ; Gonçalves, Isabel and Ruscher, Karsten LU (2019) In Frontiers in Neurology 10.
Abstract

Thyroid hormones are of fundamental importance for brain development and essential factors to warrant brain functions throughout life. Their actions are mediated by binding to specific intracellular and membranous receptors regulating genomic and non-genomic mechanisms in neurons and populations of glial cells, respectively. Among others, mechanisms include the regulation of neuronal plasticity processes, stimulation of angiogenesis and neurogenesis as well modulating the dynamics of cytoskeletal elements and intracellular transport processes. These mechanisms overlap with those that have been identified to enhance recovery of lost neurological functions during the first weeks and months after ischemic stroke. Stimulation of thyroid... (More)

Thyroid hormones are of fundamental importance for brain development and essential factors to warrant brain functions throughout life. Their actions are mediated by binding to specific intracellular and membranous receptors regulating genomic and non-genomic mechanisms in neurons and populations of glial cells, respectively. Among others, mechanisms include the regulation of neuronal plasticity processes, stimulation of angiogenesis and neurogenesis as well modulating the dynamics of cytoskeletal elements and intracellular transport processes. These mechanisms overlap with those that have been identified to enhance recovery of lost neurological functions during the first weeks and months after ischemic stroke. Stimulation of thyroid hormone signaling in the postischemic brain might be a promising therapeutic strategy to foster endogenous mechanisms of repair. Several studies have pointed to a significant association between thyroid hormones and outcome after stroke. With this review, we will provide an overview on functions of thyroid hormones in the healthy brain and summarize their mechanisms of action in the developing and adult brain. Also, we compile the major thyroid-modulated molecular pathways in the pathophysiology of ischemic stroke that can enhance recovery, highlighting thyroid hormones as a potential target for therapeutic intervention.

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publication status
published
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in
Frontiers in Neurology
volume
10
article number
1103
publisher
Frontiers
external identifiers
  • pmid:31681160
  • scopus:85074487844
ISSN
1664-2295
DOI
10.3389/fneur.2019.01103
language
English
LU publication?
yes
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919666bc-55e2-4279-be16-8d40bac16978
date added to LUP
2019-11-07 14:01:22
date last changed
2020-09-23 07:58:55
@article{919666bc-55e2-4279-be16-8d40bac16978,
  abstract     = {<p>Thyroid hormones are of fundamental importance for brain development and essential factors to warrant brain functions throughout life. Their actions are mediated by binding to specific intracellular and membranous receptors regulating genomic and non-genomic mechanisms in neurons and populations of glial cells, respectively. Among others, mechanisms include the regulation of neuronal plasticity processes, stimulation of angiogenesis and neurogenesis as well modulating the dynamics of cytoskeletal elements and intracellular transport processes. These mechanisms overlap with those that have been identified to enhance recovery of lost neurological functions during the first weeks and months after ischemic stroke. Stimulation of thyroid hormone signaling in the postischemic brain might be a promising therapeutic strategy to foster endogenous mechanisms of repair. Several studies have pointed to a significant association between thyroid hormones and outcome after stroke. With this review, we will provide an overview on functions of thyroid hormones in the healthy brain and summarize their mechanisms of action in the developing and adult brain. Also, we compile the major thyroid-modulated molecular pathways in the pathophysiology of ischemic stroke that can enhance recovery, highlighting thyroid hormones as a potential target for therapeutic intervention.</p>},
  author       = {Talhada, Daniela and Santos, Cecília Reis Alves and Gonçalves, Isabel and Ruscher, Karsten},
  issn         = {1664-2295},
  language     = {eng},
  publisher    = {Frontiers},
  series       = {Frontiers in Neurology},
  title        = {Thyroid Hormones in the Brain and Their Impact in Recovery Mechanisms After Stroke},
  url          = {http://dx.doi.org/10.3389/fneur.2019.01103},
  doi          = {10.3389/fneur.2019.01103},
  volume       = {10},
  year         = {2019},
}