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Preeclampsia associates with asthma, allergy, and eczema in childhood

Stokholm, Jakob; Sevelsted, Astrid; Dolberg Anderson, Ulrik LU and Bisgaard, Hans (2017) In American Journal of Respiratory and Critical Care Medicine 195(5). p.614-621
Abstract

Rationale: Preeclampsia reflects an unusual increase in systemic inflammation during pregnancy. Objectives: We studied associations between preeclampsia and asthma, allergy, and eczema in Copenhagen Prospective Studies on Asthma in Childhood2000 (COPSAC2000) and in national registries. Methods: COPSAC2000 is a high-risk birth cohort of 411 Danish children. Asthma, allergy, and eczema were diagnosed prospectively, and lung function measured at age 1 month and 7 years. Sensitization was evaluated at age 6 months, 18 months, 4 years, and 6 years by skin prick tests and IgE measurements. The register-based cohort included 1.7 million children from Danish national registries in the 35-year period 1977-2012. Children born to mothers with... (More)

Rationale: Preeclampsia reflects an unusual increase in systemic inflammation during pregnancy. Objectives: We studied associations between preeclampsia and asthma, allergy, and eczema in Copenhagen Prospective Studies on Asthma in Childhood2000 (COPSAC2000) and in national registries. Methods: COPSAC2000 is a high-risk birth cohort of 411 Danish children. Asthma, allergy, and eczema were diagnosed prospectively, and lung function measured at age 1 month and 7 years. Sensitization was evaluated at age 6 months, 18 months, 4 years, and 6 years by skin prick tests and IgE measurements. The register-based cohort included 1.7 million children from Danish national registries in the 35-year period 1977-2012. Children born to mothers with preeclampsia were analyzed regarding risk of asthma, allergy, and eczema. Measurements and Main Results: In the COPSAC2000 cohort, 5.6% (n = 23) were diagnosed with preeclampsia. Preeclampsia was associated with increased risk of treatment with inhaled corticosteroids at age 7 years (adjusted odds ratio, 4.01 [95% confidence interval (CI), 1.11-14.43]; P = 0.0337), increased bronchial responsiveness to methacholine (adjusted b-coefficient log-mmol, 20.80 [95% CI, 21.55 to 20.06]; P = 0.0348), and allergic rhinitis (adjusted odds ratio, 4.83 [95% CI, 1.58-14.78]; P = 0.0057) in the 7-year-old children. Furthermore, the children had an increased risk of sensitization to both aeroallergens and food allergens, and increased amount of total IgE during childhood. In the registry-based cohort, 3.7% (n = 62,728) were born to mothers with preeclampsia. Preeclampsia was associated with increased risk of asthma, eczema, and aeroallergen and food allergy, especially pronounced after a duration of preeclampsia of 14 days or more. Maternal asthma increased the risk of preeclampsia. Conclusions: Preeclampsia is a shared prenatal risk factor for asthma, eczema, and allergy in childhood pointing toward in utero immune programming of the child.

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author
organization
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type
Contribution to journal
publication status
published
subject
keywords
Asthma, Atopic, Dermatitis, Embryonic and fetal development, Hypersensitivity, Preeclampsia
in
American Journal of Respiratory and Critical Care Medicine
volume
195
issue
5
pages
8 pages
publisher
Am Thoracic Soc
external identifiers
  • scopus:85014747583
  • wos:000395357400011
ISSN
1073-449X
DOI
10.1164/rccm.201604-0806OC
language
English
LU publication?
yes
id
91d25c2c-dfc6-467a-9426-c9f3197ae5a1
date added to LUP
2017-04-11 15:52:02
date last changed
2018-05-20 04:33:06
@article{91d25c2c-dfc6-467a-9426-c9f3197ae5a1,
  abstract     = {<p>Rationale: Preeclampsia reflects an unusual increase in systemic inflammation during pregnancy. Objectives: We studied associations between preeclampsia and asthma, allergy, and eczema in Copenhagen Prospective Studies on Asthma in Childhood2000 (COPSAC2000) and in national registries. Methods: COPSAC2000 is a high-risk birth cohort of 411 Danish children. Asthma, allergy, and eczema were diagnosed prospectively, and lung function measured at age 1 month and 7 years. Sensitization was evaluated at age 6 months, 18 months, 4 years, and 6 years by skin prick tests and IgE measurements. The register-based cohort included 1.7 million children from Danish national registries in the 35-year period 1977-2012. Children born to mothers with preeclampsia were analyzed regarding risk of asthma, allergy, and eczema. Measurements and Main Results: In the COPSAC2000 cohort, 5.6% (n = 23) were diagnosed with preeclampsia. Preeclampsia was associated with increased risk of treatment with inhaled corticosteroids at age 7 years (adjusted odds ratio, 4.01 [95% confidence interval (CI), 1.11-14.43]; P = 0.0337), increased bronchial responsiveness to methacholine (adjusted b-coefficient log-mmol, 20.80 [95% CI, 21.55 to 20.06]; P = 0.0348), and allergic rhinitis (adjusted odds ratio, 4.83 [95% CI, 1.58-14.78]; P = 0.0057) in the 7-year-old children. Furthermore, the children had an increased risk of sensitization to both aeroallergens and food allergens, and increased amount of total IgE during childhood. In the registry-based cohort, 3.7% (n = 62,728) were born to mothers with preeclampsia. Preeclampsia was associated with increased risk of asthma, eczema, and aeroallergen and food allergy, especially pronounced after a duration of preeclampsia of 14 days or more. Maternal asthma increased the risk of preeclampsia. Conclusions: Preeclampsia is a shared prenatal risk factor for asthma, eczema, and allergy in childhood pointing toward in utero immune programming of the child.</p>},
  author       = {Stokholm, Jakob and Sevelsted, Astrid and Dolberg Anderson, Ulrik and Bisgaard, Hans},
  issn         = {1073-449X},
  keyword      = {Asthma,Atopic,Dermatitis,Embryonic and fetal development,Hypersensitivity,Preeclampsia},
  language     = {eng},
  month        = {03},
  number       = {5},
  pages        = {614--621},
  publisher    = {Am Thoracic Soc},
  series       = {American Journal of Respiratory and Critical Care Medicine},
  title        = {Preeclampsia associates with asthma, allergy, and eczema in childhood},
  url          = {http://dx.doi.org/10.1164/rccm.201604-0806OC},
  volume       = {195},
  year         = {2017},
}