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Update in antibiotic therapy in intensive care unit : report from the 2019 Nîmes International Symposium

Leone, Marc ; Roberts, Jason A. ; Bassetti, Matteo ; Bouglé, Adrien ; Lavigne, Jean Philippe ; Legrand, Matthieu ; Neely, Michael ; Paiva, José Artur ; Payen, Didier and Rello, Jordi , et al. (2019) In Anaesthesia Critical Care & Pain Medicine 38(6). p.647-656
Abstract

The 2019 Nîmes International Symposium in Antibiotic Therapy Optimisation aimed at determining the best approaches of a number of the antibiotic management strategies for critically ill patients. Experts reviewed the latest literature relating to requirements for an optimal antibiotic stewardship program, risks of sub-therapeutic dosing of antibiotics in critically ill patients, persisting issues about efficiency of combination therapy and the value of de-escalation, new perspectives of pharmacokinetics, drug toxicities including collateral damages-associated with antibiotics, the place of nebulisation of antibiotics, management of patients receiving extracorporeal therapies and the place of new antibiotics. In this paper, each of these... (More)

The 2019 Nîmes International Symposium in Antibiotic Therapy Optimisation aimed at determining the best approaches of a number of the antibiotic management strategies for critically ill patients. Experts reviewed the latest literature relating to requirements for an optimal antibiotic stewardship program, risks of sub-therapeutic dosing of antibiotics in critically ill patients, persisting issues about efficiency of combination therapy and the value of de-escalation, new perspectives of pharmacokinetics, drug toxicities including collateral damages-associated with antibiotics, the place of nebulisation of antibiotics, management of patients receiving extracorporeal therapies and the place of new antibiotics. In this paper, each of these issues is discussed with key messages presented after a brief review of evidence.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Antibiotics, De-escalation, Dosing, Sepsis, Stewardship
in
Anaesthesia Critical Care & Pain Medicine
volume
38
issue
6
pages
647 - 656
publisher
Elsevier Masson SAS
external identifiers
  • scopus:85074481073
  • pmid:31606548
ISSN
2352-5568
DOI
10.1016/j.accpm.2019.09.009
language
English
LU publication?
yes
id
91e9142f-9bea-4247-b04e-9591172f0591
date added to LUP
2019-11-27 13:56:28
date last changed
2024-05-15 02:42:04
@article{91e9142f-9bea-4247-b04e-9591172f0591,
  abstract     = {{<p>The 2019 Nîmes International Symposium in Antibiotic Therapy Optimisation aimed at determining the best approaches of a number of the antibiotic management strategies for critically ill patients. Experts reviewed the latest literature relating to requirements for an optimal antibiotic stewardship program, risks of sub-therapeutic dosing of antibiotics in critically ill patients, persisting issues about efficiency of combination therapy and the value of de-escalation, new perspectives of pharmacokinetics, drug toxicities including collateral damages-associated with antibiotics, the place of nebulisation of antibiotics, management of patients receiving extracorporeal therapies and the place of new antibiotics. In this paper, each of these issues is discussed with key messages presented after a brief review of evidence.</p>}},
  author       = {{Leone, Marc and Roberts, Jason A. and Bassetti, Matteo and Bouglé, Adrien and Lavigne, Jean Philippe and Legrand, Matthieu and Neely, Michael and Paiva, José Artur and Payen, Didier and Rello, Jordi and Roger, Claire and Sjövall, Fredrik and Jung, Boris}},
  issn         = {{2352-5568}},
  keywords     = {{Antibiotics; De-escalation; Dosing; Sepsis; Stewardship}},
  language     = {{eng}},
  month        = {{10}},
  number       = {{6}},
  pages        = {{647--656}},
  publisher    = {{Elsevier Masson SAS}},
  series       = {{Anaesthesia Critical Care & Pain Medicine}},
  title        = {{Update in antibiotic therapy in intensive care unit : report from the 2019 Nîmes International Symposium}},
  url          = {{http://dx.doi.org/10.1016/j.accpm.2019.09.009}},
  doi          = {{10.1016/j.accpm.2019.09.009}},
  volume       = {{38}},
  year         = {{2019}},
}