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Sex-and age-related variations in myocardial tissue composition of the healthy heart : a native T1 mapping cohort study

Myhr, Katrine Aagaard ; Andrés-Jensen, Liv ; Larsen, Bjørn Strøier ; Kunkel, Joakim Bo ; Kristensen, Charlotte Burup LU orcid ; Vejlstrup, Niels ; Køber, Lars and Pecini, Redi (2024) In European Heart Journal Cardiovascular Imaging 25(8). p.1109-1117
Abstract

Aims: Cardiovascular diseases manifest differently in males and females, potentially influenced by inherent sex- and age-related differences in myocardial tissue composition. Such inherent differences are not well-established in the literature. With this study using cardiac magnetic resonance (CMR) native T1 mapping, we aim to determine the effect of sex and age on myocardial tissue composition in healthy individuals. Methods and results: CMR native T1 mapping was performed in 276 healthy individuals (55% male, age 8 - -84 years) on a 1.5 Tesla scanner using a MOLLI 5(3)3 acquisition scheme. Additionally, 30 healthy participants (47% male, age 24-68 years) underwent a 1-year follow-up CMR to assess the longitudinal changes of native T1.... (More)

Aims: Cardiovascular diseases manifest differently in males and females, potentially influenced by inherent sex- and age-related differences in myocardial tissue composition. Such inherent differences are not well-established in the literature. With this study using cardiac magnetic resonance (CMR) native T1 mapping, we aim to determine the effect of sex and age on myocardial tissue composition in healthy individuals. Methods and results: CMR native T1 mapping was performed in 276 healthy individuals (55% male, age 8 - -84 years) on a 1.5 Tesla scanner using a MOLLI 5(3)3 acquisition scheme. Additionally, 30 healthy participants (47% male, age 24-68 years) underwent a 1-year follow-up CMR to assess the longitudinal changes of native T1. Mean native T1 values were 1000 ± 22 ms in males and 1022 ± 23 ms in females [mean difference (MD) = 22 ms, 95% confidence interval (CI) (17, 27)]. Female sex was associated with higher native T1 in multivariable linear regression adjusting for age, heart rate, left ventricular mass index, and blood T1 [β=10 ms, 95% CI (3.4, 15.8)]. There was no significant interaction between sex and age (P = 0.27). Further, age was not associated with native T1 [β=0.1 ms, 95% CI (-0.02, 0.2)], and native T1 did not change during a 1-year period [MD -4 ms, 95% CI (-11, 3)]. Conclusion: Female sex was associated with higher native T1; however, there was no association between age and native T1. Additionally, there was no evidence of an interaction between sex and age. Our findings indicate intrinsic sex-based disparities in myocardial tissue composition.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cardiac magnetic resonance, myocardial fibrosis, myocardial tissue composition, native T1 mapping
in
European Heart Journal Cardiovascular Imaging
volume
25
issue
8
pages
9 pages
publisher
Oxford University Press
external identifiers
  • pmid:38469906
  • scopus:85200275075
ISSN
2047-2404
DOI
10.1093/ehjci/jeae070
language
English
LU publication?
yes
id
9220ccf3-9561-4722-83aa-f618f370dfd6
date added to LUP
2024-09-09 13:09:19
date last changed
2024-09-09 13:09:42
@article{9220ccf3-9561-4722-83aa-f618f370dfd6,
  abstract     = {{<p>Aims: Cardiovascular diseases manifest differently in males and females, potentially influenced by inherent sex- and age-related differences in myocardial tissue composition. Such inherent differences are not well-established in the literature. With this study using cardiac magnetic resonance (CMR) native T1 mapping, we aim to determine the effect of sex and age on myocardial tissue composition in healthy individuals. Methods and results: CMR native T1 mapping was performed in 276 healthy individuals (55% male, age 8 - -84 years) on a 1.5 Tesla scanner using a MOLLI 5(3)3 acquisition scheme. Additionally, 30 healthy participants (47% male, age 24-68 years) underwent a 1-year follow-up CMR to assess the longitudinal changes of native T1. Mean native T1 values were 1000 ± 22 ms in males and 1022 ± 23 ms in females [mean difference (MD) = 22 ms, 95% confidence interval (CI) (17, 27)]. Female sex was associated with higher native T1 in multivariable linear regression adjusting for age, heart rate, left ventricular mass index, and blood T1 [β=10 ms, 95% CI (3.4, 15.8)]. There was no significant interaction between sex and age (P = 0.27). Further, age was not associated with native T1 [β=0.1 ms, 95% CI (-0.02, 0.2)], and native T1 did not change during a 1-year period [MD -4 ms, 95% CI (-11, 3)]. Conclusion: Female sex was associated with higher native T1; however, there was no association between age and native T1. Additionally, there was no evidence of an interaction between sex and age. Our findings indicate intrinsic sex-based disparities in myocardial tissue composition.</p>}},
  author       = {{Myhr, Katrine Aagaard and Andrés-Jensen, Liv and Larsen, Bjørn Strøier and Kunkel, Joakim Bo and Kristensen, Charlotte Burup and Vejlstrup, Niels and Køber, Lars and Pecini, Redi}},
  issn         = {{2047-2404}},
  keywords     = {{cardiac magnetic resonance; myocardial fibrosis; myocardial tissue composition; native T1 mapping}},
  language     = {{eng}},
  number       = {{8}},
  pages        = {{1109--1117}},
  publisher    = {{Oxford University Press}},
  series       = {{European Heart Journal Cardiovascular Imaging}},
  title        = {{Sex-and age-related variations in myocardial tissue composition of the healthy heart : a native T1 mapping cohort study}},
  url          = {{http://dx.doi.org/10.1093/ehjci/jeae070}},
  doi          = {{10.1093/ehjci/jeae070}},
  volume       = {{25}},
  year         = {{2024}},
}