Memantine improves attention and episodic memory in Parkinson's disease dementia and dementia with Lewy bodies
(2015) In International Journal of Geriatric Psychiatry 30(1). p.46-54- Abstract
- ObjectiveIn both dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD), attentional dysfunction is a core clinical feature together with disrupted episodic memory. This study evaluated the cognitive effects of memantine in DLB and PDD using automated tests of attention and episodic memory. MethodsA randomised double-blind, placebo-controlled, 24-week three centre trial of memantine (20mg/day) was conducted in which tests of attention (simple and choice reaction time) and word recognition (immediate and delayed) from the CDR System were administered prior to dosing and again at 12 and 24weeks. Although other results from this study have been published, the data from the CDR System tests were not included and are presented... (More)
- ObjectiveIn both dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD), attentional dysfunction is a core clinical feature together with disrupted episodic memory. This study evaluated the cognitive effects of memantine in DLB and PDD using automated tests of attention and episodic memory. MethodsA randomised double-blind, placebo-controlled, 24-week three centre trial of memantine (20mg/day) was conducted in which tests of attention (simple and choice reaction time) and word recognition (immediate and delayed) from the CDR System were administered prior to dosing and again at 12 and 24weeks. Although other results from this study have been published, the data from the CDR System tests were not included and are presented here for the first time. ResultsData were available for 51 patients (21 DLB and 30 PDD). In both populations, memantine produced statistically significant medium to large effect sized improvements to choice reaction time, immediate and delayed word recognition. ConclusionsThese are the first substantial improvements on cognitive tests of attention and episodic recognition memory identified with memantine in either DLB or PDD. Copyright (c) 2014 John Wiley & Sons, Ltd. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4941593
- author
- Wesnes, Keith A. ; Aarsland, Dag ; Ballard, Clive and Londos, Elisabet LU
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- memantine, dementia with Lewy bodies, Parkinson's disease dementia, attention, episodic memory, CDR System, automated cognitive tests
- in
- International Journal of Geriatric Psychiatry
- volume
- 30
- issue
- 1
- pages
- 46 - 54
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000346278300005
- scopus:84918769295
- pmid:24737460
- ISSN
- 1099-1166
- DOI
- 10.1002/gps.4109
- language
- English
- LU publication?
- yes
- id
- 92249c70-8375-4d54-a275-ef5f2bc4dc9a (old id 4941593)
- date added to LUP
- 2016-04-01 09:50:27
- date last changed
- 2022-05-17 17:27:23
@article{92249c70-8375-4d54-a275-ef5f2bc4dc9a,
abstract = {{ObjectiveIn both dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD), attentional dysfunction is a core clinical feature together with disrupted episodic memory. This study evaluated the cognitive effects of memantine in DLB and PDD using automated tests of attention and episodic memory. MethodsA randomised double-blind, placebo-controlled, 24-week three centre trial of memantine (20mg/day) was conducted in which tests of attention (simple and choice reaction time) and word recognition (immediate and delayed) from the CDR System were administered prior to dosing and again at 12 and 24weeks. Although other results from this study have been published, the data from the CDR System tests were not included and are presented here for the first time. ResultsData were available for 51 patients (21 DLB and 30 PDD). In both populations, memantine produced statistically significant medium to large effect sized improvements to choice reaction time, immediate and delayed word recognition. ConclusionsThese are the first substantial improvements on cognitive tests of attention and episodic recognition memory identified with memantine in either DLB or PDD. Copyright (c) 2014 John Wiley & Sons, Ltd.}},
author = {{Wesnes, Keith A. and Aarsland, Dag and Ballard, Clive and Londos, Elisabet}},
issn = {{1099-1166}},
keywords = {{memantine; dementia with Lewy bodies; Parkinson's disease dementia; attention; episodic memory; CDR System; automated cognitive tests}},
language = {{eng}},
number = {{1}},
pages = {{46--54}},
publisher = {{John Wiley & Sons Inc.}},
series = {{International Journal of Geriatric Psychiatry}},
title = {{Memantine improves attention and episodic memory in Parkinson's disease dementia and dementia with Lewy bodies}},
url = {{http://dx.doi.org/10.1002/gps.4109}},
doi = {{10.1002/gps.4109}},
volume = {{30}},
year = {{2015}},
}