Synthesis of molecularly imprinted polymers using a functionalized initiator for chiral-selective recognition of propranolol
Liu, Weifeng ; Holdsworth, Clovia and Ye, Lei LU
(2020)
In Chirality
32.
p.370-377
- Abstract
- We present a new concept of synthesis for preparation of molecularly imprinted polymers using a functionalized initiator to replace the traditional functional monomer. Using propranolol as a model template, a carboxyl‐functionalized radical initiator was demonstrated to lead to high‐selectivity polymer particles prepared in a standard precipitation polymerization system. When a single enantiomer of propranolol was used as template, the imprinted polymer particles exhibited clear chiral selectivity in an equilibrium binding experiment. Unlike the previous molecular imprinting systems where the active free radicals can be distant from the template‐functional monomer complex, the method reported in this work makes sure that the actual radical... (More)
- We present a new concept of synthesis for preparation of molecularly imprinted polymers using a functionalized initiator to replace the traditional functional monomer. Using propranolol as a model template, a carboxyl‐functionalized radical initiator was demonstrated to lead to high‐selectivity polymer particles prepared in a standard precipitation polymerization system. When a single enantiomer of propranolol was used as template, the imprinted polymer particles exhibited clear chiral selectivity in an equilibrium binding experiment. Unlike the previous molecular imprinting systems where the active free radicals can be distant from the template‐functional monomer complex, the method reported in this work makes sure that the actual radical polymerization takes place in the vicinity of the template‐associated functional groups. The success of using functional initiator to synthesize molecularly imprinted polymers brings in new possibilities to improve the functional performance of molecularly imprinted synthetic receptors. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/922e47b0-0e5b-4d09-9d96-ba8e30ad1eb9
- author
- Liu, Weifeng
; Holdsworth, Clovia
and Ye, Lei
LU
- organization
- publishing date
- 2020
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Chirality
- volume
- 32
- pages
- 370 - 377
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:31930590
- scopus:85077904781
- ISSN
- 1520-636X
- DOI
- 10.1002/chir.23167
- language
- English
- LU publication?
- yes
- id
- 922e47b0-0e5b-4d09-9d96-ba8e30ad1eb9
- date added to LUP
- 2020-08-09 11:40:30
- date last changed
- 2022-04-19 00:02:40
@article{922e47b0-0e5b-4d09-9d96-ba8e30ad1eb9,
abstract = {{We present a new concept of synthesis for preparation of molecularly imprinted polymers using a functionalized initiator to replace the traditional functional monomer. Using propranolol as a model template, a carboxyl‐functionalized radical initiator was demonstrated to lead to high‐selectivity polymer particles prepared in a standard precipitation polymerization system. When a single enantiomer of propranolol was used as template, the imprinted polymer particles exhibited clear chiral selectivity in an equilibrium binding experiment. Unlike the previous molecular imprinting systems where the active free radicals can be distant from the template‐functional monomer complex, the method reported in this work makes sure that the actual radical polymerization takes place in the vicinity of the template‐associated functional groups. The success of using functional initiator to synthesize molecularly imprinted polymers brings in new possibilities to improve the functional performance of molecularly imprinted synthetic receptors.}},
author = {{Liu, Weifeng and Holdsworth, Clovia and Ye, Lei}},
issn = {{1520-636X}},
language = {{eng}},
pages = {{370--377}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Chirality}},
title = {{Synthesis of molecularly imprinted polymers using a functionalized initiator for chiral-selective recognition of propranolol}},
url = {{http://dx.doi.org/10.1002/chir.23167}},
doi = {{10.1002/chir.23167}},
volume = {{32}},
year = {{2020}},
}