Spinal Cord Stimulation Restores Locomotion in Animal Models of Parkinson's Disease
(2009) In Science 323(5921). p.1578-1582- Abstract
- Dopamine replacement therapy is useful for treating motor symptoms in the early phase of Parkinson's disease, but it is less effective in the long term. Electrical deep-brain stimulation is a valuable complement to pharmacological treatment but involves a highly invasive surgical procedure. We found that epidural electrical stimulation of the dorsal columns in the spinal cord restores locomotion in both acute pharmacologically induced dopamine-depleted mice and in chronic 6-hydroxydopamine-lesioned rats. The functional recovery was paralleled by a disruption of aberrant low-frequency synchronous corticostriatal oscillations, leading to the emergence of neuronal activity patterns that resemble the state normally preceding spontaneous... (More)
- Dopamine replacement therapy is useful for treating motor symptoms in the early phase of Parkinson's disease, but it is less effective in the long term. Electrical deep-brain stimulation is a valuable complement to pharmacological treatment but involves a highly invasive surgical procedure. We found that epidural electrical stimulation of the dorsal columns in the spinal cord restores locomotion in both acute pharmacologically induced dopamine-depleted mice and in chronic 6-hydroxydopamine-lesioned rats. The functional recovery was paralleled by a disruption of aberrant low-frequency synchronous corticostriatal oscillations, leading to the emergence of neuronal activity patterns that resemble the state normally preceding spontaneous initiation of locomotion. We propose that dorsal column stimulation might become an efficient and less invasive alternative for treatment of Parkinson's disease in the future. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1402475
- author
- Fuentes, Romulo ; Petersson, Per LU ; Siesser, William B. ; Caron, Marc G. and Nicolelis, Miguel A. L.
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Science
- volume
- 323
- issue
- 5921
- pages
- 1578 - 1582
- publisher
- American Association for the Advancement of Science (AAAS)
- external identifiers
-
- wos:000264342300031
- scopus:62849093978
- pmid:19299613
- ISSN
- 1095-9203
- DOI
- 10.1126/science.1164901
- language
- English
- LU publication?
- yes
- id
- 92323e37-fa32-4e9e-b8af-96015a4654c2 (old id 1402475)
- date added to LUP
- 2016-04-01 14:12:13
- date last changed
- 2022-09-27 08:33:30
@article{92323e37-fa32-4e9e-b8af-96015a4654c2,
abstract = {{Dopamine replacement therapy is useful for treating motor symptoms in the early phase of Parkinson's disease, but it is less effective in the long term. Electrical deep-brain stimulation is a valuable complement to pharmacological treatment but involves a highly invasive surgical procedure. We found that epidural electrical stimulation of the dorsal columns in the spinal cord restores locomotion in both acute pharmacologically induced dopamine-depleted mice and in chronic 6-hydroxydopamine-lesioned rats. The functional recovery was paralleled by a disruption of aberrant low-frequency synchronous corticostriatal oscillations, leading to the emergence of neuronal activity patterns that resemble the state normally preceding spontaneous initiation of locomotion. We propose that dorsal column stimulation might become an efficient and less invasive alternative for treatment of Parkinson's disease in the future.}},
author = {{Fuentes, Romulo and Petersson, Per and Siesser, William B. and Caron, Marc G. and Nicolelis, Miguel A. L.}},
issn = {{1095-9203}},
language = {{eng}},
number = {{5921}},
pages = {{1578--1582}},
publisher = {{American Association for the Advancement of Science (AAAS)}},
series = {{Science}},
title = {{Spinal Cord Stimulation Restores Locomotion in Animal Models of Parkinson's Disease}},
url = {{http://dx.doi.org/10.1126/science.1164901}},
doi = {{10.1126/science.1164901}},
volume = {{323}},
year = {{2009}},
}