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Cytokines in gingival crevicular fluid in elderly rheumatoid arthritis patients in a population-based cross-sectional study : RANTES was associated with periodontitis

Söderlin, Maria K. LU ; Persson, Gösta Rutger ; Renvert, Stefan and Sanmartin Berglund, Johan (2021) In Journal of Periodontal Research 56(5). p.907-916
Abstract

Objective: We studied cytokines in gingival crevicular fluid (GCF) in a cross-sectional population-based cohort of rheumatoid arthritis (RA) patients ≥61 years of age with and without a diagnosis of periodontitis. Background data: Earlier studies on cytokines in GCF in RA patients have not given clear results. Methods: In a population-based cross-sectional study of patients ≥61 years of age, 233 RA patients were identified. 132 (57%) dentate RA patients participated. All participants received rheumatological and dental examinations, and had a panoramic radiograph taken. GCF was sampled on each patient. Interleukins 1-β (IL-1β), IL-4, IL-6, IL-10, IL-17A, tumor necrosis factor alpha (TNF-α), interferon gamma (IFN-γ), and chemokines... (More)

Objective: We studied cytokines in gingival crevicular fluid (GCF) in a cross-sectional population-based cohort of rheumatoid arthritis (RA) patients ≥61 years of age with and without a diagnosis of periodontitis. Background data: Earlier studies on cytokines in GCF in RA patients have not given clear results. Methods: In a population-based cross-sectional study of patients ≥61 years of age, 233 RA patients were identified. 132 (57%) dentate RA patients participated. All participants received rheumatological and dental examinations, and had a panoramic radiograph taken. GCF was sampled on each patient. Interleukins 1-β (IL-1β), IL-4, IL-6, IL-10, IL-17A, tumor necrosis factor alpha (TNF-α), interferon gamma (IFN-γ), and chemokines RANTES/CCL5, eotaxin and monocyte chemoattractant protein (MCP-1) were analyzed in GCF. These cytokines were stratified for periodontitis, age, gender, body mass index (BMI), smoking, and anti-cyclic citrullinated protein (anti-CCP) status. Binary logistic regression analyses with periodontitis as outcome were performed adjusting for the above mentioned confounding factors including anti-rheumatic medication, disease duration and the cytokine in question. Results: Periodontitis was diagnosed in 80/132 (61%) of study participants. The 110 RA patients not participating were older, had a higher mean erythrocyte sedimentation rate (ESR), had a higher mean DAS28ESR (Disease Activity Score 28 using ESR) and were less often on biologic treatment. Only RANTES was associated with periodontitis (p =.049, OR 1.001, 95% CI 1.000–1.002) in the binary logistic regression analyses. Conclusion: In this population-based elderly RA cohort, neither pro-inflammatory nor anti-inflammatory cytokines in GCF were clearly associated with a diagnosis of periodontitis.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cytokines, gingival crevicular fluid, periodontitis, rheumatoid arthritis
in
Journal of Periodontal Research
volume
56
issue
5
pages
907 - 916
publisher
Wiley-Blackwell
external identifiers
  • scopus:85105232771
  • pmid:33954982
ISSN
0022-3484
DOI
10.1111/jre.12887
language
English
LU publication?
yes
id
926d6577-d320-4b3f-abe9-5e15d5e6f5c5
date added to LUP
2021-05-31 15:02:20
date last changed
2024-06-15 11:53:14
@article{926d6577-d320-4b3f-abe9-5e15d5e6f5c5,
  abstract     = {{<p>Objective: We studied cytokines in gingival crevicular fluid (GCF) in a cross-sectional population-based cohort of rheumatoid arthritis (RA) patients ≥61 years of age with and without a diagnosis of periodontitis. Background data: Earlier studies on cytokines in GCF in RA patients have not given clear results. Methods: In a population-based cross-sectional study of patients ≥61 years of age, 233 RA patients were identified. 132 (57%) dentate RA patients participated. All participants received rheumatological and dental examinations, and had a panoramic radiograph taken. GCF was sampled on each patient. Interleukins 1-β (IL-1β), IL-4, IL-6, IL-10, IL-17A, tumor necrosis factor alpha (TNF-α), interferon gamma (IFN-γ), and chemokines RANTES/CCL5, eotaxin and monocyte chemoattractant protein (MCP-1) were analyzed in GCF. These cytokines were stratified for periodontitis, age, gender, body mass index (BMI), smoking, and anti-cyclic citrullinated protein (anti-CCP) status. Binary logistic regression analyses with periodontitis as outcome were performed adjusting for the above mentioned confounding factors including anti-rheumatic medication, disease duration and the cytokine in question. Results: Periodontitis was diagnosed in 80/132 (61%) of study participants. The 110 RA patients not participating were older, had a higher mean erythrocyte sedimentation rate (ESR), had a higher mean DAS28ESR (Disease Activity Score 28 using ESR) and were less often on biologic treatment. Only RANTES was associated with periodontitis (p =.049, OR 1.001, 95% CI 1.000–1.002) in the binary logistic regression analyses. Conclusion: In this population-based elderly RA cohort, neither pro-inflammatory nor anti-inflammatory cytokines in GCF were clearly associated with a diagnosis of periodontitis.</p>}},
  author       = {{Söderlin, Maria K. and Persson, Gösta Rutger and Renvert, Stefan and Sanmartin Berglund, Johan}},
  issn         = {{0022-3484}},
  keywords     = {{cytokines; gingival crevicular fluid; periodontitis; rheumatoid arthritis}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{907--916}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Journal of Periodontal Research}},
  title        = {{Cytokines in gingival crevicular fluid in elderly rheumatoid arthritis patients in a population-based cross-sectional study : RANTES was associated with periodontitis}},
  url          = {{http://dx.doi.org/10.1111/jre.12887}},
  doi          = {{10.1111/jre.12887}},
  volume       = {{56}},
  year         = {{2021}},
}