Cytokines in gingival crevicular fluid in elderly rheumatoid arthritis patients in a population-based cross-sectional study : RANTES was associated with periodontitis
(2021) In Journal of Periodontal Research 56(5). p.907-916- Abstract
Objective: We studied cytokines in gingival crevicular fluid (GCF) in a cross-sectional population-based cohort of rheumatoid arthritis (RA) patients ≥61 years of age with and without a diagnosis of periodontitis. Background data: Earlier studies on cytokines in GCF in RA patients have not given clear results. Methods: In a population-based cross-sectional study of patients ≥61 years of age, 233 RA patients were identified. 132 (57%) dentate RA patients participated. All participants received rheumatological and dental examinations, and had a panoramic radiograph taken. GCF was sampled on each patient. Interleukins 1-β (IL-1β), IL-4, IL-6, IL-10, IL-17A, tumor necrosis factor alpha (TNF-α), interferon gamma (IFN-γ), and chemokines... (More)
Objective: We studied cytokines in gingival crevicular fluid (GCF) in a cross-sectional population-based cohort of rheumatoid arthritis (RA) patients ≥61 years of age with and without a diagnosis of periodontitis. Background data: Earlier studies on cytokines in GCF in RA patients have not given clear results. Methods: In a population-based cross-sectional study of patients ≥61 years of age, 233 RA patients were identified. 132 (57%) dentate RA patients participated. All participants received rheumatological and dental examinations, and had a panoramic radiograph taken. GCF was sampled on each patient. Interleukins 1-β (IL-1β), IL-4, IL-6, IL-10, IL-17A, tumor necrosis factor alpha (TNF-α), interferon gamma (IFN-γ), and chemokines RANTES/CCL5, eotaxin and monocyte chemoattractant protein (MCP-1) were analyzed in GCF. These cytokines were stratified for periodontitis, age, gender, body mass index (BMI), smoking, and anti-cyclic citrullinated protein (anti-CCP) status. Binary logistic regression analyses with periodontitis as outcome were performed adjusting for the above mentioned confounding factors including anti-rheumatic medication, disease duration and the cytokine in question. Results: Periodontitis was diagnosed in 80/132 (61%) of study participants. The 110 RA patients not participating were older, had a higher mean erythrocyte sedimentation rate (ESR), had a higher mean DAS28ESR (Disease Activity Score 28 using ESR) and were less often on biologic treatment. Only RANTES was associated with periodontitis (p =.049, OR 1.001, 95% CI 1.000–1.002) in the binary logistic regression analyses. Conclusion: In this population-based elderly RA cohort, neither pro-inflammatory nor anti-inflammatory cytokines in GCF were clearly associated with a diagnosis of periodontitis.
(Less)
- author
- Söderlin, Maria K. LU ; Persson, Gösta Rutger ; Renvert, Stefan and Sanmartin Berglund, Johan
- organization
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- cytokines, gingival crevicular fluid, periodontitis, rheumatoid arthritis
- in
- Journal of Periodontal Research
- volume
- 56
- issue
- 5
- pages
- 907 - 916
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:33954982
- scopus:85105232771
- ISSN
- 0022-3484
- DOI
- 10.1111/jre.12887
- language
- English
- LU publication?
- yes
- id
- 926d6577-d320-4b3f-abe9-5e15d5e6f5c5
- date added to LUP
- 2021-05-31 15:02:20
- date last changed
- 2025-01-13 08:46:03
@article{926d6577-d320-4b3f-abe9-5e15d5e6f5c5,
abstract = {{<p>Objective: We studied cytokines in gingival crevicular fluid (GCF) in a cross-sectional population-based cohort of rheumatoid arthritis (RA) patients ≥61 years of age with and without a diagnosis of periodontitis. Background data: Earlier studies on cytokines in GCF in RA patients have not given clear results. Methods: In a population-based cross-sectional study of patients ≥61 years of age, 233 RA patients were identified. 132 (57%) dentate RA patients participated. All participants received rheumatological and dental examinations, and had a panoramic radiograph taken. GCF was sampled on each patient. Interleukins 1-β (IL-1β), IL-4, IL-6, IL-10, IL-17A, tumor necrosis factor alpha (TNF-α), interferon gamma (IFN-γ), and chemokines RANTES/CCL5, eotaxin and monocyte chemoattractant protein (MCP-1) were analyzed in GCF. These cytokines were stratified for periodontitis, age, gender, body mass index (BMI), smoking, and anti-cyclic citrullinated protein (anti-CCP) status. Binary logistic regression analyses with periodontitis as outcome were performed adjusting for the above mentioned confounding factors including anti-rheumatic medication, disease duration and the cytokine in question. Results: Periodontitis was diagnosed in 80/132 (61%) of study participants. The 110 RA patients not participating were older, had a higher mean erythrocyte sedimentation rate (ESR), had a higher mean DAS28ESR (Disease Activity Score 28 using ESR) and were less often on biologic treatment. Only RANTES was associated with periodontitis (p =.049, OR 1.001, 95% CI 1.000–1.002) in the binary logistic regression analyses. Conclusion: In this population-based elderly RA cohort, neither pro-inflammatory nor anti-inflammatory cytokines in GCF were clearly associated with a diagnosis of periodontitis.</p>}},
author = {{Söderlin, Maria K. and Persson, Gösta Rutger and Renvert, Stefan and Sanmartin Berglund, Johan}},
issn = {{0022-3484}},
keywords = {{cytokines; gingival crevicular fluid; periodontitis; rheumatoid arthritis}},
language = {{eng}},
number = {{5}},
pages = {{907--916}},
publisher = {{Wiley-Blackwell}},
series = {{Journal of Periodontal Research}},
title = {{Cytokines in gingival crevicular fluid in elderly rheumatoid arthritis patients in a population-based cross-sectional study : RANTES was associated with periodontitis}},
url = {{http://dx.doi.org/10.1111/jre.12887}},
doi = {{10.1111/jre.12887}},
volume = {{56}},
year = {{2021}},
}