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The benefit of molecular characterization during a measles upsurge in Denmark

Muscat, Mark ; Vinner, Lasse ; Christiansen, Annette Hartvig ; Glismann, Steffen and Böttiger, Blenda Elisabeth LU (2007) In Vaccine 25(33). p.6-6232
Abstract

Molecular characterization of measles virus was part of the epidemiological investigation of 27 measles cases reported in Denmark in 2006. RT-PCR detected measles virus RNA from various types of clinical specimens in 24 cases. Virus genotypes were determined by sequencing the nucleocapsid (N) gene. Four different genotypes, B3, D4, D5 and D9 were identified including two variants of the D4 genotype. In combination with the epidemiological data four clusters of measles cases and three sporadic cases were revealed. Our study showed that measles in Denmark resulted from imported measles virus strains. The limited duration and short chain of transmission of the identified clusters ascertain that the interruption of measles virus circulation... (More)

Molecular characterization of measles virus was part of the epidemiological investigation of 27 measles cases reported in Denmark in 2006. RT-PCR detected measles virus RNA from various types of clinical specimens in 24 cases. Virus genotypes were determined by sequencing the nucleocapsid (N) gene. Four different genotypes, B3, D4, D5 and D9 were identified including two variants of the D4 genotype. In combination with the epidemiological data four clusters of measles cases and three sporadic cases were revealed. Our study showed that measles in Denmark resulted from imported measles virus strains. The limited duration and short chain of transmission of the identified clusters ascertain that the interruption of measles virus circulation is being sustained. However, measles transmission still has a potential to occur. To minimise the development of pools of susceptible individuals high (>/=95%) routine vaccination coverage with two doses of measles-containing vaccine needs to be attained. Molecular epidemiological studies have proved to be both a useful and a necessary component of an enhanced surveillance system required in the measles elimination phase.

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author
; ; ; and
publishing date
type
Contribution to journal
publication status
published
keywords
Denmark/epidemiology, Disease Outbreaks, Genotype, Humans, Measles/epidemiology, Measles virus/genetics, Molecular Epidemiology, Phylogeny, RNA, Viral/genetics
in
Vaccine
volume
25
issue
33
pages
6 - 6232
publisher
Elsevier
external identifiers
  • pmid:17629377
  • scopus:34447629053
ISSN
0264-410X
DOI
10.1016/j.vaccine.2007.05.063
language
English
LU publication?
no
id
927bd4c3-ee8f-462f-a117-9d86b0cb9c39
date added to LUP
2019-05-02 14:23:09
date last changed
2024-01-01 02:34:18
@article{927bd4c3-ee8f-462f-a117-9d86b0cb9c39,
  abstract     = {{<p>Molecular characterization of measles virus was part of the epidemiological investigation of 27 measles cases reported in Denmark in 2006. RT-PCR detected measles virus RNA from various types of clinical specimens in 24 cases. Virus genotypes were determined by sequencing the nucleocapsid (N) gene. Four different genotypes, B3, D4, D5 and D9 were identified including two variants of the D4 genotype. In combination with the epidemiological data four clusters of measles cases and three sporadic cases were revealed. Our study showed that measles in Denmark resulted from imported measles virus strains. The limited duration and short chain of transmission of the identified clusters ascertain that the interruption of measles virus circulation is being sustained. However, measles transmission still has a potential to occur. To minimise the development of pools of susceptible individuals high (&gt;/=95%) routine vaccination coverage with two doses of measles-containing vaccine needs to be attained. Molecular epidemiological studies have proved to be both a useful and a necessary component of an enhanced surveillance system required in the measles elimination phase.</p>}},
  author       = {{Muscat, Mark and Vinner, Lasse and Christiansen, Annette Hartvig and Glismann, Steffen and Böttiger, Blenda Elisabeth}},
  issn         = {{0264-410X}},
  keywords     = {{Denmark/epidemiology; Disease Outbreaks; Genotype; Humans; Measles/epidemiology; Measles virus/genetics; Molecular Epidemiology; Phylogeny; RNA, Viral/genetics}},
  language     = {{eng}},
  month        = {{08}},
  number       = {{33}},
  pages        = {{6--6232}},
  publisher    = {{Elsevier}},
  series       = {{Vaccine}},
  title        = {{The benefit of molecular characterization during a measles upsurge in Denmark}},
  url          = {{http://dx.doi.org/10.1016/j.vaccine.2007.05.063}},
  doi          = {{10.1016/j.vaccine.2007.05.063}},
  volume       = {{25}},
  year         = {{2007}},
}