How to optimize patch testing with diphenylmethane diisocyanate
(2007) In Contact Dermatitis 57(3). p.138-151- Abstract
- We have previously shown that patch test preparations of polymeric diphenylmethane diisocyanate (PMDI) are more stable than preparations of diphenylmethane-4,4'-diisocyanate (4,4'-MDI). This study was conducted to (i) investigate whether PMDIs yield as many positive reactions as 4,4'-MDI, (ii) study concurrent reactions to 4,4'-MDI and 4,4'-diaminodiphenylmethane (4,4'-MDA), and (iii) follow the course of positive reactions during 4 weeks. It was shown that PMDIs detect as many positive reactions as 4,4'-MDI. Thus, they are better patch test agents being more stable than preparations of 4,4'-MDI. We recommend that PMDIs with a monomer content of at least 35% is used in 2.0% petrolatum (pet.) (i.e. monomer patch test concentration... (More)
- We have previously shown that patch test preparations of polymeric diphenylmethane diisocyanate (PMDI) are more stable than preparations of diphenylmethane-4,4'-diisocyanate (4,4'-MDI). This study was conducted to (i) investigate whether PMDIs yield as many positive reactions as 4,4'-MDI, (ii) study concurrent reactions to 4,4'-MDI and 4,4'-diaminodiphenylmethane (4,4'-MDA), and (iii) follow the course of positive reactions during 4 weeks. It was shown that PMDIs detect as many positive reactions as 4,4'-MDI. Thus, they are better patch test agents being more stable than preparations of 4,4'-MDI. We recommend that PMDIs with a monomer content of at least 35% is used in 2.0% petrolatum (pet.) (i.e. monomer patch test concentration approximately 0.7%). It was shown that reactions to 4,4'-MDI and PMDIs appear late and we recommend readings on both day (D) 3/4 and D7. 4,4'-MDA was shown to be a good marker for 4,4'-MDI and patch testing with 4,4'-MDA in 0.25% pet. can be used instead of PMDI. Concomitant reactions to 4,4'-MDI and 4,4'-MDA are probably not caused by conversion of 4,4'-MDI into 4,4'-MDA by reaction with water. Another explanation is a path of reactions leading to ureas and MDI conjugates with skin constituents, which are hydrolysed into 4,4'-MDA. This complex process depends upon several factors and might explain why positive MDI reactions appear after D7. (Less)
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https://lup.lub.lu.se/record/647506
- author
- Engfeldt, Malin LU ; Isaksson, Marléne LU ; Zimerson, Erik LU and Bruze, Magnus LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- 4'diisocyanate, diphenlymethane-4, dermatitis, CAS 9016-87-9, allergic contact, CAS 101-68-8, MDI, PMDI, polymeric MDI
- in
- Contact Dermatitis
- volume
- 57
- issue
- 3
- pages
- 138 - 151
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000248591900001
- scopus:34547824658
- ISSN
- 0105-1873
- DOI
- 10.1111/j.1600-0536.2007.01197.x
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Occupational and Environmental Dermatology Unit (013241310), Pediatrics/Urology/Gynecology/Endocrinology (013240400)
- id
- 9280dbeb-3d5e-4c5f-a552-efe4f13af490 (old id 647506)
- date added to LUP
- 2016-04-01 11:59:32
- date last changed
- 2022-03-13 03:39:19
@article{9280dbeb-3d5e-4c5f-a552-efe4f13af490, abstract = {{We have previously shown that patch test preparations of polymeric diphenylmethane diisocyanate (PMDI) are more stable than preparations of diphenylmethane-4,4'-diisocyanate (4,4'-MDI). This study was conducted to (i) investigate whether PMDIs yield as many positive reactions as 4,4'-MDI, (ii) study concurrent reactions to 4,4'-MDI and 4,4'-diaminodiphenylmethane (4,4'-MDA), and (iii) follow the course of positive reactions during 4 weeks. It was shown that PMDIs detect as many positive reactions as 4,4'-MDI. Thus, they are better patch test agents being more stable than preparations of 4,4'-MDI. We recommend that PMDIs with a monomer content of at least 35% is used in 2.0% petrolatum (pet.) (i.e. monomer patch test concentration approximately 0.7%). It was shown that reactions to 4,4'-MDI and PMDIs appear late and we recommend readings on both day (D) 3/4 and D7. 4,4'-MDA was shown to be a good marker for 4,4'-MDI and patch testing with 4,4'-MDA in 0.25% pet. can be used instead of PMDI. Concomitant reactions to 4,4'-MDI and 4,4'-MDA are probably not caused by conversion of 4,4'-MDI into 4,4'-MDA by reaction with water. Another explanation is a path of reactions leading to ureas and MDI conjugates with skin constituents, which are hydrolysed into 4,4'-MDA. This complex process depends upon several factors and might explain why positive MDI reactions appear after D7.}}, author = {{Engfeldt, Malin and Isaksson, Marléne and Zimerson, Erik and Bruze, Magnus}}, issn = {{0105-1873}}, keywords = {{4'diisocyanate; diphenlymethane-4; dermatitis; CAS 9016-87-9; allergic contact; CAS 101-68-8; MDI; PMDI; polymeric MDI}}, language = {{eng}}, number = {{3}}, pages = {{138--151}}, publisher = {{Wiley-Blackwell}}, series = {{Contact Dermatitis}}, title = {{How to optimize patch testing with diphenylmethane diisocyanate}}, url = {{http://dx.doi.org/10.1111/j.1600-0536.2007.01197.x}}, doi = {{10.1111/j.1600-0536.2007.01197.x}}, volume = {{57}}, year = {{2007}}, }