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Early vascular ageing (EVA) : Definitions and clinical applicability

Cunha, Pedro G; Boutouyrie, Pierre; Nilsson, Peter M. LU and Laurent, Stéphane (2017) In Current Medical Imaging Reviews 13(1). p.8-15
Abstract

Arterial stiffness has been accumulating evidence as an intermediate cardiovascular endpoint. It has been established as an independent risk marker for cardiovascular disease, and reflects the dissociation between chronologic and biologic age of large arteries-attributing earlier the risk that a normal vascular ageing process had installed to occur several years later. The concept of Early Vascular Ageing (EVA) is developed to establish primordial prevention, identifying individuals whose ageing path has been accelerated either by inherent features, interaction with the environment or arterial exposure to several types of insults that evolve to medial layer morphological changes. Understanding the pathophysiology of vascular ageing, its... (More)

Arterial stiffness has been accumulating evidence as an intermediate cardiovascular endpoint. It has been established as an independent risk marker for cardiovascular disease, and reflects the dissociation between chronologic and biologic age of large arteries-attributing earlier the risk that a normal vascular ageing process had installed to occur several years later. The concept of Early Vascular Ageing (EVA) is developed to establish primordial prevention, identifying individuals whose ageing path has been accelerated either by inherent features, interaction with the environment or arterial exposure to several types of insults that evolve to medial layer morphological changes. Understanding the pathophysiology of vascular ageing, its consequences and therapeutic opportunities is therefore an advantage that could be translated in time of prevention and survival free of cardiovascular disease. As the EVA construct is advancing, new features appear as interesting to better translate it into clinical practice.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Arterial stiffness, Cardiovascular risk, Early vascular ageing, Epidemiology, Large artery, Pulse wave velocity
in
Current Medical Imaging Reviews
volume
13
issue
1
pages
8 pages
publisher
Bentham Science Publishers
external identifiers
  • scopus:85025169716
ISSN
1573-4021
DOI
10.2174/1573402113666170413094319
language
English
LU publication?
yes
id
92afc6a4-34f1-4648-8901-ada2effb33cc
date added to LUP
2017-08-31 13:33:53
date last changed
2018-06-10 05:22:34
@article{92afc6a4-34f1-4648-8901-ada2effb33cc,
  abstract     = {<p>Arterial stiffness has been accumulating evidence as an intermediate cardiovascular endpoint. It has been established as an independent risk marker for cardiovascular disease, and reflects the dissociation between chronologic and biologic age of large arteries-attributing earlier the risk that a normal vascular ageing process had installed to occur several years later. The concept of Early Vascular Ageing (EVA) is developed to establish primordial prevention, identifying individuals whose ageing path has been accelerated either by inherent features, interaction with the environment or arterial exposure to several types of insults that evolve to medial layer morphological changes. Understanding the pathophysiology of vascular ageing, its consequences and therapeutic opportunities is therefore an advantage that could be translated in time of prevention and survival free of cardiovascular disease. As the EVA construct is advancing, new features appear as interesting to better translate it into clinical practice.</p>},
  author       = {Cunha, Pedro G and Boutouyrie, Pierre and Nilsson, Peter M. and Laurent, Stéphane},
  issn         = {1573-4021},
  keyword      = {Arterial stiffness,Cardiovascular risk,Early vascular ageing,Epidemiology,Large artery,Pulse wave velocity},
  language     = {eng},
  number       = {1},
  pages        = {8--15},
  publisher    = {Bentham Science Publishers},
  series       = {Current Medical Imaging Reviews},
  title        = {Early vascular ageing (EVA) : Definitions and clinical applicability},
  url          = {http://dx.doi.org/10.2174/1573402113666170413094319},
  volume       = {13},
  year         = {2017},
}