Therapy Effects in Cerebral Folate Transport Deficiency with Hypomyelination Monitored by Multimodal Quantitative MR-Imaging
(2013) In Proceedings of the International Society for Magnetic Resonance in Medicine 21. p.1080-1080- Abstract
- Myelin-sensitive quantitative (q) MRI techniques including MT (3D FLASH) and DTI (single-shot STEAM) are of growing importance to study white matter (WM) disorders in childhood. Cerebral folate transport deficiency is an inherited, treatable WM disorder with hypomyelination, developmental regression, movement disturbances, and epilepsy. One patient with this diagnosis and severe phenotype was treated with folinic acid. Concomitant serial qMRI study over 4.2 yrs indicated an advancement of myelination which was paralleled by clinical improvement. In contrast to structural MRI, MT saturation maps demonstrated striking contrast changes and detailed spatial resolution. It may provide a valuable parameter to monitor therapy effects.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/92c3f4a9-db7a-4865-89f4-235e5be2e577
- author
- Dreha-Kulaczewski, Steffi F. ; Steinfeld, Robert ; Brockmann, Knut ; Dechent, Peter ; Gärtner, Jutta and Helms, Gunther LU
- publishing date
- 2013-04
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- folate deficiency
- in
- Proceedings of the International Society for Magnetic Resonance in Medicine
- volume
- 21
- pages
- 1080 - 1080
- publisher
- International Society for Magnetic Resonance in Medicine
- ISSN
- 1524-6965
- language
- English
- LU publication?
- no
- id
- 92c3f4a9-db7a-4865-89f4-235e5be2e577
- date added to LUP
- 2017-01-20 14:37:16
- date last changed
- 2020-11-12 02:21:03
@misc{92c3f4a9-db7a-4865-89f4-235e5be2e577, abstract = {{Myelin-sensitive quantitative (q) MRI techniques including MT (3D FLASH) and DTI (single-shot STEAM) are of growing importance to study white matter (WM) disorders in childhood. Cerebral folate transport deficiency is an inherited, treatable WM disorder with hypomyelination, developmental regression, movement disturbances, and epilepsy. One patient with this diagnosis and severe phenotype was treated with folinic acid. Concomitant serial qMRI study over 4.2 yrs indicated an advancement of myelination which was paralleled by clinical improvement. In contrast to structural MRI, MT saturation maps demonstrated striking contrast changes and detailed spatial resolution. It may provide a valuable parameter to monitor therapy effects.}}, author = {{Dreha-Kulaczewski, Steffi F. and Steinfeld, Robert and Brockmann, Knut and Dechent, Peter and Gärtner, Jutta and Helms, Gunther}}, issn = {{1524-6965}}, keywords = {{folate deficiency}}, language = {{eng}}, note = {{Conference Abstract}}, pages = {{1080--1080}}, publisher = {{International Society for Magnetic Resonance in Medicine}}, series = {{Proceedings of the International Society for Magnetic Resonance in Medicine}}, title = {{Therapy Effects in Cerebral Folate Transport Deficiency with Hypomyelination Monitored by Multimodal Quantitative MR-Imaging}}, url = {{https://lup.lub.lu.se/search/files/20185493/ISMRM13_1080.pdf}}, volume = {{21}}, year = {{2013}}, }