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POPULATION ANALYSIS OF PROTECTION BY HLA‐DR AND DQ GENES FROM INSULIN‐DEPENDENT DIABETES MELLITUS IN SWEDISH CHILDREN WITH INSULIN‐DEPENDENT DIABETES AND CONTROLS

Kockum, I. ; Sanjeevi, C. B. ; Eastman, S. ; Landin‐Olsson, M. LU ; Dahlouist, G. and Lernmark, Å LU orcid (1995) In International Journal of Immunogenetics 22(6). p.443-465
Abstract

A negative association between insulin‐dependent diabetes mellitus (IDDM) and HLA‐DR, DQA1 or DQB1 was found in a large population‐based investigation of childhood‐onset patients (more than 420 patients) and controls (more than 340 controls) from Sweden. The relative risk was decreased for several haplotypes that were negatively associated with IDDM: DR15‐DQA1*0102‐DQB1*0602, DR7‐DQA1*0201‐DQB1*0303, DR14‐DQA1*0101‐DQB1*0503, DRI1‐DQAI*0501‐DQB1*0301, DR13‐DQA1*0103‐DQB1*0603 and DR4‐DQA1*0301‐DQB1*0301. In a relative predispositional effect (RPE) analysis, however, only the DR15‐DQA1*0102‐DQB1*0602 haplotype was significantly decreased, which suggests that the major protective effect for IDDM is carried by this haplotype. This was... (More)

A negative association between insulin‐dependent diabetes mellitus (IDDM) and HLA‐DR, DQA1 or DQB1 was found in a large population‐based investigation of childhood‐onset patients (more than 420 patients) and controls (more than 340 controls) from Sweden. The relative risk was decreased for several haplotypes that were negatively associated with IDDM: DR15‐DQA1*0102‐DQB1*0602, DR7‐DQA1*0201‐DQB1*0303, DR14‐DQA1*0101‐DQB1*0503, DRI1‐DQAI*0501‐DQB1*0301, DR13‐DQA1*0103‐DQB1*0603 and DR4‐DQA1*0301‐DQB1*0301. In a relative predispositional effect (RPE) analysis, however, only the DR15‐DQA1*0102‐DQB1*0602 haplotype was significantly decreased, which suggests that the major protective effect for IDDM is carried by this haplotype. This was supported by the observation that all genotypes which were negatively associated with IDDM, except DR7/13, included at least one allele from the DR15‐DQA1*0102‐DQB1*0602 haplotype. Relative predispositional effect (RPE) analysis of genotypes showed further that the DR15‐DQA1*0102‐DQB1*0602 haplotype was also negatively associated with IDDM when combined with any other haplotype, whether negatively or positively associated with IDDM. This supports previous suggestions that DR15‐DQA1*0102‐DQB1*0602 acts dominantly. However, both the stratification and the predispositional allele test failed to distinguish the negative association between IDDM and DR15 from that of DQBT0602. On the other hand, these tests indicated that DQA1*0102 was not likely to explain the negative association between IDDM and the DR15‐DQA1*0102‐DQB1*0602 haplotype. We conclude that the

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Journal of Immunogenetics
volume
22
issue
6
pages
443 - 465
publisher
Wiley-Blackwell
external identifiers
  • pmid:8597561
  • scopus:0028882717
ISSN
1744-3121
DOI
10.1111/j.1744-313X.1995.tb00282.x
language
English
LU publication?
yes
id
92c840b8-57fa-4051-94c2-abe17ef50c6a
date added to LUP
2019-09-11 09:00:45
date last changed
2024-03-13 08:14:10
@article{92c840b8-57fa-4051-94c2-abe17ef50c6a,
  abstract     = {{<p>A negative association between insulin‐dependent diabetes mellitus (IDDM) and HLA‐DR, DQA1 or DQB1 was found in a large population‐based investigation of childhood‐onset patients (more than 420 patients) and controls (more than 340 controls) from Sweden. The relative risk was decreased for several haplotypes that were negatively associated with IDDM: DR15‐DQA1*0102‐DQB1*0602, DR7‐DQA1*0201‐DQB1*0303, DR14‐DQA1*0101‐DQB1*0503, DRI1‐DQAI*0501‐DQB1*0301, DR13‐DQA1*0103‐DQB1*0603 and DR4‐DQA1*0301‐DQB1*0301. In a relative predispositional effect (RPE) analysis, however, only the DR15‐DQA1*0102‐DQB1*0602 haplotype was significantly decreased, which suggests that the major protective effect for IDDM is carried by this haplotype. This was supported by the observation that all genotypes which were negatively associated with IDDM, except DR7/13, included at least one allele from the DR15‐DQA1*0102‐DQB1*0602 haplotype. Relative predispositional effect (RPE) analysis of genotypes showed further that the DR15‐DQA1*0102‐DQB1*0602 haplotype was also negatively associated with IDDM when combined with any other haplotype, whether negatively or positively associated with IDDM. This supports previous suggestions that DR15‐DQA1*0102‐DQB1*0602 acts dominantly. However, both the stratification and the predispositional allele test failed to distinguish the negative association between IDDM and DR15 from that of DQBT0602. On the other hand, these tests indicated that DQA1*0102 was not likely to explain the negative association between IDDM and the DR15‐DQA1*0102‐DQB1*0602 haplotype. We conclude that the</p>}},
  author       = {{Kockum, I. and Sanjeevi, C. B. and Eastman, S. and Landin‐Olsson, M. and Dahlouist, G. and Lernmark, Å}},
  issn         = {{1744-3121}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{6}},
  pages        = {{443--465}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{International Journal of Immunogenetics}},
  title        = {{POPULATION ANALYSIS OF PROTECTION BY HLA‐DR AND DQ GENES FROM INSULIN‐DEPENDENT DIABETES MELLITUS IN SWEDISH CHILDREN WITH INSULIN‐DEPENDENT DIABETES AND CONTROLS}},
  url          = {{http://dx.doi.org/10.1111/j.1744-313X.1995.tb00282.x}},
  doi          = {{10.1111/j.1744-313X.1995.tb00282.x}},
  volume       = {{22}},
  year         = {{1995}},
}