Controlling the hydration of the skin though the application of occluding barrier creams.
(2013) In Journal of the Royal Society Interface 10(80).- Abstract
- The skin is a barrier membrane that separates environments with profoundly different water contents. The barrier properties are assured by the outer layer of the skin, the stratum corneum (SC), which controls the transepidermal water loss. The SC acts as a responding membrane, since its hydration and permeability vary with the boundary condition, which is the activity of water at the outer surface of the skin. We show how this boundary condition can be changed by the application of a barrier cream that makes a film with a high resistance to the transport of water. We present a quantitative model that predicts hydration and water transport in SC that is covered by such a film. We also develop an experimental method for measuring the... (More)
- The skin is a barrier membrane that separates environments with profoundly different water contents. The barrier properties are assured by the outer layer of the skin, the stratum corneum (SC), which controls the transepidermal water loss. The SC acts as a responding membrane, since its hydration and permeability vary with the boundary condition, which is the activity of water at the outer surface of the skin. We show how this boundary condition can be changed by the application of a barrier cream that makes a film with a high resistance to the transport of water. We present a quantitative model that predicts hydration and water transport in SC that is covered by such a film. We also develop an experimental method for measuring the specific resistance to water transport of films made of occluding barrier creams. Finally, we combine the theoretical model with the measured properties of the barrier creams to predict how a film of cream changes the activity of water at the outer surface of the SC. Using the known variations of SC permeability and hydration with the water activity in its environment (i.e. the relative humidity), we can thus predict how a film of barrier cream changes SC hydration. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3346891
- author
- Sparr, Emma LU ; Millecamps, Danielle ; Isoir, Muriel ; Burnier, Véronique ; Larsson, Åsa LU and Cabane, Bernard
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of the Royal Society Interface
- volume
- 10
- issue
- 80
- article number
- 20120788
- publisher
- The Royal Society of Canada
- external identifiers
-
- wos:000314285400006
- pmid:23269846
- scopus:84879162016
- ISSN
- 1742-5662
- DOI
- 10.1098/rsif.2012.0788
- language
- English
- LU publication?
- yes
- id
- 92f6eb73-ef7e-45ee-9015-cf92dc6d17a9 (old id 3346891)
- date added to LUP
- 2016-04-01 10:55:01
- date last changed
- 2022-04-04 22:25:04
@article{92f6eb73-ef7e-45ee-9015-cf92dc6d17a9,
abstract = {{The skin is a barrier membrane that separates environments with profoundly different water contents. The barrier properties are assured by the outer layer of the skin, the stratum corneum (SC), which controls the transepidermal water loss. The SC acts as a responding membrane, since its hydration and permeability vary with the boundary condition, which is the activity of water at the outer surface of the skin. We show how this boundary condition can be changed by the application of a barrier cream that makes a film with a high resistance to the transport of water. We present a quantitative model that predicts hydration and water transport in SC that is covered by such a film. We also develop an experimental method for measuring the specific resistance to water transport of films made of occluding barrier creams. Finally, we combine the theoretical model with the measured properties of the barrier creams to predict how a film of cream changes the activity of water at the outer surface of the SC. Using the known variations of SC permeability and hydration with the water activity in its environment (i.e. the relative humidity), we can thus predict how a film of barrier cream changes SC hydration.}},
author = {{Sparr, Emma and Millecamps, Danielle and Isoir, Muriel and Burnier, Véronique and Larsson, Åsa and Cabane, Bernard}},
issn = {{1742-5662}},
language = {{eng}},
number = {{80}},
publisher = {{The Royal Society of Canada}},
series = {{Journal of the Royal Society Interface}},
title = {{Controlling the hydration of the skin though the application of occluding barrier creams.}},
url = {{http://dx.doi.org/10.1098/rsif.2012.0788}},
doi = {{10.1098/rsif.2012.0788}},
volume = {{10}},
year = {{2013}},
}