The Wisdom in Teeth : Neuronal Differentiation of Dental Pulp Cells
Sramkó, Bendegúz ; Földes, Anna ; Kádár, Kristóf ; Varga, Gábor ; Zsembery, Ákos and Pircs, Karolina LU
(2023)
In Cellular Reprogramming
25(1).
p.32-44
- Abstract
Mesenchymal stem/stromal cells (MSCs) are found in almost all postnatal organs. Under appropriate environmental cues, multipotency enables MSCs to serve as progenitors for several lineage-specific, differentiated cell types. In vitro expansion and differentiation of MSCs give the opportunity to obtain hardly available somatic cells, such as neurons. The neurogenic potential of MSCs makes them a promising, autologous source to restore damaged tissue and as such, they have received much attention in the field of regenerative medicine. Several stem cell pool candidates have been studied thus far, but only a few of them showed neurogenic differentiation potential. Due to their embryonic ontology, stem cells residing in the stroma of the... (More)
Mesenchymal stem/stromal cells (MSCs) are found in almost all postnatal organs. Under appropriate environmental cues, multipotency enables MSCs to serve as progenitors for several lineage-specific, differentiated cell types. In vitro expansion and differentiation of MSCs give the opportunity to obtain hardly available somatic cells, such as neurons. The neurogenic potential of MSCs makes them a promising, autologous source to restore damaged tissue and as such, they have received much attention in the field of regenerative medicine. Several stem cell pool candidates have been studied thus far, but only a few of them showed neurogenic differentiation potential. Due to their embryonic ontology, stem cells residing in the stroma of the dental pulp chamber are an exciting source for in vitro neural cell differentiation. In this study, we review the key properties of dental pulp stem cells (DPSCs), with a particular focus on their neurogenic potential. Moreover, we summarize the various presently available methods used for neural differentiation of human DPSCs also emphasizing the difficulties in reproducibly high production of such cells. We postulate that because DPSCs are stem cells with very close ontology to neurogenic lineages, they may serve as excellent targets for neuronal differentiation in vitro and even for direct reprogramming.
(Less)
- author
- Sramkó, Bendegúz
; Földes, Anna
; Kádár, Kristóf
; Varga, Gábor
; Zsembery, Ákos
and Pircs, Karolina
LU
- organization
- publishing date
- 2023-02
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- dental pulp stem cells, mesenchymal stem cells, neural crest, neural differentiation, reprogramming
- in
- Cellular Reprogramming
- volume
- 25
- issue
- 1
- pages
- 13 pages
- publisher
- Mary Ann Liebert, Inc.
- external identifiers
-
- pmid:36719998
- scopus:85148249981
- ISSN
- 2152-4971
- DOI
- 10.1089/cell.2022.0102
- language
- English
- LU publication?
- yes
- id
- 9303396b-ea1b-4e32-9470-542c00ccfcd5
- date added to LUP
- 2023-03-06 11:02:31
- date last changed
- 2024-06-25 10:06:06
@article{9303396b-ea1b-4e32-9470-542c00ccfcd5,
abstract = {{<p>Mesenchymal stem/stromal cells (MSCs) are found in almost all postnatal organs. Under appropriate environmental cues, multipotency enables MSCs to serve as progenitors for several lineage-specific, differentiated cell types. In vitro expansion and differentiation of MSCs give the opportunity to obtain hardly available somatic cells, such as neurons. The neurogenic potential of MSCs makes them a promising, autologous source to restore damaged tissue and as such, they have received much attention in the field of regenerative medicine. Several stem cell pool candidates have been studied thus far, but only a few of them showed neurogenic differentiation potential. Due to their embryonic ontology, stem cells residing in the stroma of the dental pulp chamber are an exciting source for in vitro neural cell differentiation. In this study, we review the key properties of dental pulp stem cells (DPSCs), with a particular focus on their neurogenic potential. Moreover, we summarize the various presently available methods used for neural differentiation of human DPSCs also emphasizing the difficulties in reproducibly high production of such cells. We postulate that because DPSCs are stem cells with very close ontology to neurogenic lineages, they may serve as excellent targets for neuronal differentiation in vitro and even for direct reprogramming.</p>}},
author = {{Sramkó, Bendegúz and Földes, Anna and Kádár, Kristóf and Varga, Gábor and Zsembery, Ákos and Pircs, Karolina}},
issn = {{2152-4971}},
keywords = {{dental pulp stem cells; mesenchymal stem cells; neural crest; neural differentiation; reprogramming}},
language = {{eng}},
number = {{1}},
pages = {{32--44}},
publisher = {{Mary Ann Liebert, Inc.}},
series = {{Cellular Reprogramming}},
title = {{The Wisdom in Teeth : Neuronal Differentiation of Dental Pulp Cells}},
url = {{http://dx.doi.org/10.1089/cell.2022.0102}},
doi = {{10.1089/cell.2022.0102}},
volume = {{25}},
year = {{2023}},
}