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MicroRNAs in Retinal Pathophysiology and Therapeutics

Ahuja, Satpal LU (2011) p.199-211
Abstract
Following identification of tRNA and rRNA, the non-protein coding RNAs (ncRNAs) have been demonstrated to possess catalytic ribozyme functions (Cech et al., 1981; Guerrier-Takada et al., 1983). In recognition of the latter work, T.R. Cech and S. Altman were awarded the 1989 Noble Prize in Chemistry. Fire, et al. (1998) discovered that small double stranded RNA (ds RNA) silences the gene expression. For this observation Andre Fire and C.C. Mello earned the 2006 Nobel Prize in Physiology or Medicine. Two years later, V.R. Ambros, D.C. Baucombe, and G.B. Ruvkun were honored with the Albert Lasker Basic Medical Research Award (2008) for their contributions in the field of small RNA dependent gene regulation in plants and animals. All these... (More)
Following identification of tRNA and rRNA, the non-protein coding RNAs (ncRNAs) have been demonstrated to possess catalytic ribozyme functions (Cech et al., 1981; Guerrier-Takada et al., 1983). In recognition of the latter work, T.R. Cech and S. Altman were awarded the 1989 Noble Prize in Chemistry. Fire, et al. (1998) discovered that small double stranded RNA (ds RNA) silences the gene expression. For this observation Andre Fire and C.C. Mello earned the 2006 Nobel Prize in Physiology or Medicine. Two years later, V.R. Ambros, D.C. Baucombe, and G.B. Ruvkun were honored with the Albert Lasker Basic Medical Research Award (2008) for their contributions in the field of small RNA dependent gene regulation in plants and animals. All these findings have revolutionized the fields of gene regulation, RNA biology and brought out the possibilities of its exploitation for understanding the living processes and for use as therapeutic agents. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
host publication
Usher Syndrome: Pathogenesis, Diagnosis and Therapy
editor
Ahuja, S.
pages
199 - 211
publisher
Nova Science Publishers, Inc.
ISBN
978-1-61209-227-0
language
English
LU publication?
yes
id
9337a095-4398-4ffe-a456-3cbff323f171
date added to LUP
2017-10-17 11:20:53
date last changed
2018-11-21 21:35:21
@inbook{9337a095-4398-4ffe-a456-3cbff323f171,
  abstract     = {{Following identification of tRNA and rRNA, the non-protein coding RNAs (ncRNAs) have been demonstrated to possess catalytic ribozyme functions (Cech et al., 1981; Guerrier-Takada et al., 1983). In recognition of the latter work, T.R. Cech and S. Altman were awarded the 1989 Noble Prize in Chemistry. Fire, et al. (1998) discovered that small double stranded RNA (ds RNA) silences the gene expression. For this observation Andre Fire and C.C. Mello earned the 2006 Nobel Prize in Physiology or Medicine. Two years later, V.R. Ambros, D.C. Baucombe, and G.B. Ruvkun were honored with the Albert Lasker Basic Medical Research Award (2008) for their contributions in the field of small RNA dependent gene regulation in plants and animals. All these findings have revolutionized the fields of gene regulation, RNA biology and brought out the possibilities of its exploitation for understanding the living processes and for use as therapeutic agents.}},
  author       = {{Ahuja, Satpal}},
  booktitle    = {{Usher Syndrome: Pathogenesis, Diagnosis and Therapy}},
  editor       = {{Ahuja, S.}},
  isbn         = {{978-1-61209-227-0}},
  language     = {{eng}},
  pages        = {{199--211}},
  publisher    = {{Nova Science Publishers, Inc.}},
  title        = {{MicroRNAs in Retinal Pathophysiology and Therapeutics}},
  year         = {{2011}},
}