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MicroRNAs in Retinal Pathophysiology and Therapeutics

Ahuja, Satpal LU (2011) In Usher Syndrome: Pathogenesis, Diagnosis and Therapy p.199-211
Abstract
Following identification of tRNA and rRNA, the non-protein coding RNAs (ncRNAs) have been demonstrated to possess catalytic ribozyme functions (Cech et al., 1981; Guerrier-Takada et al., 1983). In recognition of the latter work, T.R. Cech and S. Altman were awarded the 1989 Noble Prize in Chemistry. Fire, et al. (1998) discovered that small double stranded RNA (ds RNA) silences the gene expression. For this observation Andre Fire and C.C. Mello earned the 2006 Nobel Prize in Physiology or Medicine. Two years later, V.R. Ambros, D.C. Baucombe, and G.B. Ruvkun were honored with the Albert Lasker Basic Medical Research Award (2008) for their contributions in the field of small RNA dependent gene regulation in plants and animals. All these... (More)
Following identification of tRNA and rRNA, the non-protein coding RNAs (ncRNAs) have been demonstrated to possess catalytic ribozyme functions (Cech et al., 1981; Guerrier-Takada et al., 1983). In recognition of the latter work, T.R. Cech and S. Altman were awarded the 1989 Noble Prize in Chemistry. Fire, et al. (1998) discovered that small double stranded RNA (ds RNA) silences the gene expression. For this observation Andre Fire and C.C. Mello earned the 2006 Nobel Prize in Physiology or Medicine. Two years later, V.R. Ambros, D.C. Baucombe, and G.B. Ruvkun were honored with the Albert Lasker Basic Medical Research Award (2008) for their contributions in the field of small RNA dependent gene regulation in plants and animals. All these findings have revolutionized the fields of gene regulation, RNA biology and brought out the possibilities of its exploitation for understanding the living processes and for use as therapeutic agents. (Less)
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Chapter in Book/Report/Conference proceeding
publication status
published
subject
in
Usher Syndrome: Pathogenesis, Diagnosis and Therapy
editor
Ahuja, S. and
pages
199 - 211
publisher
Nova Science Publishers, Inc.
ISBN
978-1-61209-227-0
language
English
LU publication?
yes
id
9337a095-4398-4ffe-a456-3cbff323f171
date added to LUP
2017-10-17 11:20:53
date last changed
2017-10-17 11:35:36
@inbook{9337a095-4398-4ffe-a456-3cbff323f171,
  abstract     = {Following identification of tRNA and rRNA, the non-protein coding RNAs (ncRNAs) have been demonstrated to possess catalytic ribozyme functions (Cech et al., 1981; Guerrier-Takada et al., 1983). In recognition of the latter work, T.R. Cech and S. Altman were awarded the 1989 Noble Prize in Chemistry. Fire, et al. (1998) discovered that small double stranded RNA (ds RNA) silences the gene expression. For this observation Andre Fire and C.C. Mello earned the 2006 Nobel Prize in Physiology or Medicine. Two years later, V.R. Ambros, D.C. Baucombe, and G.B. Ruvkun were honored with the Albert Lasker Basic Medical Research Award (2008) for their contributions in the field of small RNA dependent gene regulation in plants and animals. All these findings have revolutionized the fields of gene regulation, RNA biology and brought out the possibilities of its exploitation for understanding the living processes and for use as therapeutic agents. },
  author       = {Ahuja, Satpal},
  editor       = {Ahuja, S.},
  isbn         = {978-1-61209-227-0},
  language     = {eng},
  pages        = {199--211},
  publisher    = {Nova Science Publishers, Inc.},
  series       = {Usher Syndrome: Pathogenesis, Diagnosis and Therapy},
  title        = {MicroRNAs in Retinal Pathophysiology and Therapeutics},
  year         = {2011},
}