Rebuilding limbs, one cell at a time
Leigh, Nicholas D LU
and Currie, Joshua D
(2022)
In Developmental Dynamics
251(9).
p.1389-1403
- Abstract
- The regeneration of salamander limbs has been a special fascination among scientists and keen observers for centuries. Perhaps due to how closely the salamander's limb anatomically mirrors our own, a grand aspiration of regenerative medicine has been to provoke such a process following injury or loss of human limbs. Research in the last century has focused on understanding the blastema, a proliferative cell mass that develops after limb amputation (see Box 1 “A primer on limb regeneration” and reviews for discussion of foundational knowledge1-3). The first micrographs of limb blastemas (examples in Thornton4 and Hay5) brought limb regeneration to a cellular level and ushered in a new era of questions centered around the origin, potency,... (More)
- The regeneration of salamander limbs has been a special fascination among scientists and keen observers for centuries. Perhaps due to how closely the salamander's limb anatomically mirrors our own, a grand aspiration of regenerative medicine has been to provoke such a process following injury or loss of human limbs. Research in the last century has focused on understanding the blastema, a proliferative cell mass that develops after limb amputation (see Box 1 “A primer on limb regeneration” and reviews for discussion of foundational knowledge1-3). The first micrographs of limb blastemas (examples in Thornton4 and Hay5) brought limb regeneration to a cellular level and ushered in a new era of questions centered around the origin, potency, and processes of regenerative cells that has occupied the field ever since. Within this commentary, we will outline some of these persistent questions underlying limb regeneration, and how new technologies and approaches are paving the way toward a cellular understanding of complex tissue regeneration. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/933a6102-46e0-4738-af3e-e45c2b28fb52
- author
- Leigh, Nicholas D
LU
and Currie, Joshua D
- organization
- publishing date
- 2022
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Developmental Dynamics
- volume
- 251
- issue
- 9
- pages
- 1389 - 1403
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:35170828
- scopus:85126006065
- ISSN
- 1097-0177
- DOI
- 10.1002/dvdy.463
- language
- English
- LU publication?
- yes
- id
- 933a6102-46e0-4738-af3e-e45c2b28fb52
- date added to LUP
- 2022-03-12 18:10:14
- date last changed
- 2024-06-20 18:57:29
@article{933a6102-46e0-4738-af3e-e45c2b28fb52,
abstract = {{The regeneration of salamander limbs has been a special fascination among scientists and keen observers for centuries. Perhaps due to how closely the salamander's limb anatomically mirrors our own, a grand aspiration of regenerative medicine has been to provoke such a process following injury or loss of human limbs. Research in the last century has focused on understanding the blastema, a proliferative cell mass that develops after limb amputation (see Box 1 “A primer on limb regeneration” and reviews for discussion of foundational knowledge1-3). The first micrographs of limb blastemas (examples in Thornton4 and Hay5) brought limb regeneration to a cellular level and ushered in a new era of questions centered around the origin, potency, and processes of regenerative cells that has occupied the field ever since. Within this commentary, we will outline some of these persistent questions underlying limb regeneration, and how new technologies and approaches are paving the way toward a cellular understanding of complex tissue regeneration.}},
author = {{Leigh, Nicholas D and Currie, Joshua D}},
issn = {{1097-0177}},
language = {{eng}},
number = {{9}},
pages = {{1389--1403}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Developmental Dynamics}},
title = {{Rebuilding limbs, one cell at a time}},
url = {{http://dx.doi.org/10.1002/dvdy.463}},
doi = {{10.1002/dvdy.463}},
volume = {{251}},
year = {{2022}},
}