Head-to-head comparison of relative cerebral blood flow derived from dynamic [18F]florbetapir and [18F]flortaucipir PET in subjects with subjective cognitive decline
(2023) In EJNMMI Research 13(1).- Abstract
Background: Dynamic PET imaging studies provide accurate estimates of specific binding, but also measure the relative tracer delivery (R1), which is a proxy for relative cerebral blood flow (rCBF). Recently, studies suggested that R1 obtained from different tracers could be used interchangeably and is irrespective of target tissue. However, the similarities or differences of R1 obtained from different PET tracers still require validation. Therefore, the goal of the current study was to compare R1 estimates, derived from dynamic [18F]florbetapir (amyloid) and [18F]flortaucipir (tau) PET, in the same subjects with subjective cognitive decline (SCD). Results: Voxel-wise... (More)
Background: Dynamic PET imaging studies provide accurate estimates of specific binding, but also measure the relative tracer delivery (R1), which is a proxy for relative cerebral blood flow (rCBF). Recently, studies suggested that R1 obtained from different tracers could be used interchangeably and is irrespective of target tissue. However, the similarities or differences of R1 obtained from different PET tracers still require validation. Therefore, the goal of the current study was to compare R1 estimates, derived from dynamic [18F]florbetapir (amyloid) and [18F]flortaucipir (tau) PET, in the same subjects with subjective cognitive decline (SCD). Results: Voxel-wise analysis presented a small cluster (1.6% of the whole brain) with higher R1 values for [18F]flortaucipir compared to [18F]florbetapir in the Aβ-negative group. These voxels were part of the hippocampus and the left middle occipital gyrus. In part of the thalamus, midbrain and cerebellum, voxels (2.5% of the whole brain) with higher R1 values for [18F]florbetapir were observed. In the Aβ-positive group, a cluster (0.2% of the whole brain) of higher R1 values was observed in part of the hippocampus, right parahippocampal gyrus and in the left sagittal stratum for [18F]flortaucipir compared to [18F]florbetapir. Furthermore, in part of the thalamus, left amygdala, midbrain and right parahippocampal gyrus voxels (0.4% of the whole brain) with higher R1 values for [18F]florbetapir were observed. Despite these differences, [18F]florbetapir R1 had high correspondence with [18F]flortaucipir R1 across all regions of interest (ROIs) and subjects (Aβ−:r 2 = 0.79, slope = 0.85, ICC = 0.76; Aβ+: r 2 = 0.87, slope = 0.93, ICC = 0.77). Conclusion: [18F]flortaucipir and [18F]florbetapir showed similar R1 estimates in cortical regions. This finding, put together with previous studies, indicates that R1 could be considered a surrogate for relative cerebral blood flow (rCBF) in the cortex and may be used interchangeably, but with caution, regardless of the choice of these two tracers.
(Less)
- author
- Tuncel, Hayel ; Visser, Denise ; Timmers, Tessa ; Wolters, Emma E. ; Ossenkoppele, Rik LU ; van der Flier, Wiesje M. ; van Berckel, Bart N.M. ; Boellaard, Ronald and Golla, Sandeep S.V.
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- PET, Relative cerebral blood flow, SCD, [F]florbetapir, [F]flortaucipir
- in
- EJNMMI Research
- volume
- 13
- issue
- 1
- article number
- 93
- publisher
- BioMed Central (BMC)
- external identifiers
-
- pmid:37889456
- scopus:85175047071
- ISSN
- 2191-219X
- DOI
- 10.1186/s13550-023-01041-x
- language
- English
- LU publication?
- yes
- additional info
- Funding Information: Research of the Alzheimer Center Amsterdam is part of the neurodegeneration research programme of Amsterdam Neuroscience. The Alzheimer Center Amsterdam is supported by Stichting Alzheimer Nederland and Stichting VUMC funds. Wiesje van der Flier holds the Pasman chair. The SCIENCe project is supported by research grants from Gieskes-Strijbis fonds and Stichting Dioraphte. Publisher Copyright: © 2023, The Author(s).
- id
- 936f3e68-d2f3-45ce-bdf4-95a0b8e05b87
- date added to LUP
- 2023-12-13 15:01:54
- date last changed
- 2024-04-12 06:51:15
@article{936f3e68-d2f3-45ce-bdf4-95a0b8e05b87,
abstract = {{<p>Background: Dynamic PET imaging studies provide accurate estimates of specific binding, but also measure the relative tracer delivery (R<sub>1</sub>), which is a proxy for relative cerebral blood flow (rCBF). Recently, studies suggested that R<sub>1</sub> obtained from different tracers could be used interchangeably and is irrespective of target tissue. However, the similarities or differences of R<sub>1</sub> obtained from different PET tracers still require validation. Therefore, the goal of the current study was to compare R<sub>1</sub> estimates, derived from dynamic [<sup>18</sup>F]florbetapir (amyloid) and [<sup>18</sup>F]flortaucipir (tau) PET, in the same subjects with subjective cognitive decline (SCD). Results: Voxel-wise analysis presented a small cluster (1.6% of the whole brain) with higher R<sub>1</sub> values for [<sup>18</sup>F]flortaucipir compared to [<sup>18</sup>F]florbetapir in the Aβ-negative group. These voxels were part of the hippocampus and the left middle occipital gyrus. In part of the thalamus, midbrain and cerebellum, voxels (2.5% of the whole brain) with higher R<sub>1</sub> values for [<sup>18</sup>F]florbetapir were observed. In the Aβ-positive group, a cluster (0.2% of the whole brain) of higher R<sub>1</sub> values was observed in part of the hippocampus, right parahippocampal gyrus and in the left sagittal stratum for [<sup>18</sup>F]flortaucipir compared to [<sup>18</sup>F]florbetapir. Furthermore, in part of the thalamus, left amygdala, midbrain and right parahippocampal gyrus voxels (0.4% of the whole brain) with higher R<sub>1</sub> values for [<sup>18</sup>F]florbetapir were observed. Despite these differences, [<sup>18</sup>F]florbetapir R<sub>1</sub> had high correspondence with [<sup>18</sup>F]flortaucipir R<sub>1</sub> across all regions of interest (ROIs) and subjects (Aβ−:r <sup>2</sup> = 0.79, slope = 0.85, ICC = 0.76; Aβ+: r <sup>2</sup> = 0.87, slope = 0.93, ICC = 0.77). Conclusion: [<sup>18</sup>F]flortaucipir and [<sup>18</sup>F]florbetapir showed similar R<sub>1</sub> estimates in cortical regions. This finding, put together with previous studies, indicates that R<sub>1</sub> could be considered a surrogate for relative cerebral blood flow (rCBF) in the cortex and may be used interchangeably, but with caution, regardless of the choice of these two tracers.</p>}},
author = {{Tuncel, Hayel and Visser, Denise and Timmers, Tessa and Wolters, Emma E. and Ossenkoppele, Rik and van der Flier, Wiesje M. and van Berckel, Bart N.M. and Boellaard, Ronald and Golla, Sandeep S.V.}},
issn = {{2191-219X}},
keywords = {{PET; Relative cerebral blood flow; SCD; [F]florbetapir; [F]flortaucipir}},
language = {{eng}},
number = {{1}},
publisher = {{BioMed Central (BMC)}},
series = {{EJNMMI Research}},
title = {{Head-to-head comparison of relative cerebral blood flow derived from dynamic [<sup>18</sup>F]florbetapir and [<sup>18</sup>F]flortaucipir PET in subjects with subjective cognitive decline}},
url = {{http://dx.doi.org/10.1186/s13550-023-01041-x}},
doi = {{10.1186/s13550-023-01041-x}},
volume = {{13}},
year = {{2023}},
}