DNA binding to SMC ATPases-trapped for release
Schüler, Herwig LU
and Sjögren, Camilla
(2016)
In EMBO Journal
35(7).
p.5-703
- Abstract
The SMC/Rad50/RecN proteins are universal DNA‐associated ABC‐type ATPases with crucial functions in genome maintenance. New insights into Rad50-DNA complex structure and cohesin regulation inspire a speculative look at the entire superfamily. Identification of a continuous DNA binding site across the Rad50 dimer interface (Liu et al, 2016; Seifert et al, 2016) suggests a similar site in cohesin. The localization of this site hints a DNA-activated mechanism for cohesin removal from chromosomes.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/937b49de-6ca5-4f07-a3ac-ecfcca02c216
- author
- Schüler, Herwig
LU
and Sjögren, Camilla
- publishing date
- 2016-04-01
- type
- Contribution to journal
- publication status
- published
- keywords
- Adenosine Triphosphate/metabolism, Archaeal Proteins/metabolism, Chaetomium/metabolism, DNA/metabolism, DNA, Fungal/metabolism, Fungal Proteins/metabolism, Methanococcus/metabolism
- in
- EMBO Journal
- volume
- 35
- issue
- 7
- pages
- 3 pages
- publisher
- Oxford University Press
- external identifiers
-
- pmid:26968982
- scopus:84960894716
- ISSN
- 1460-2075
- DOI
- 10.15252/embj.201694210
- language
- English
- LU publication?
- no
- id
- 937b49de-6ca5-4f07-a3ac-ecfcca02c216
- date added to LUP
- 2024-11-21 18:07:57
- date last changed
- 2025-01-03 07:49:34
@article{937b49de-6ca5-4f07-a3ac-ecfcca02c216,
abstract = {{<p>The SMC/Rad50/RecN proteins are universal DNA‐associated ABC‐type ATPases with crucial functions in genome maintenance. New insights into Rad50-DNA complex structure and cohesin regulation inspire a speculative look at the entire superfamily. Identification of a continuous DNA binding site across the Rad50 dimer interface (Liu et al, 2016; Seifert et al, 2016) suggests a similar site in cohesin. The localization of this site hints a DNA-activated mechanism for cohesin removal from chromosomes.</p>}},
author = {{Schüler, Herwig and Sjögren, Camilla}},
issn = {{1460-2075}},
keywords = {{Adenosine Triphosphate/metabolism; Archaeal Proteins/metabolism; Chaetomium/metabolism; DNA/metabolism; DNA, Fungal/metabolism; Fungal Proteins/metabolism; Methanococcus/metabolism}},
language = {{eng}},
month = {{04}},
number = {{7}},
pages = {{5--703}},
publisher = {{Oxford University Press}},
series = {{EMBO Journal}},
title = {{DNA binding to SMC ATPases-trapped for release}},
url = {{http://dx.doi.org/10.15252/embj.201694210}},
doi = {{10.15252/embj.201694210}},
volume = {{35}},
year = {{2016}},
}