Regulation of biological processes by ubiquitin ligases: a focus on the Pagano Lab's contribution
(2024) In Frontiers in Cell and Developmental Biology 12.- Abstract
Protein homeostasis depends on many fundamental processes including mRNA synthesis, translation, post-translational modifications, and proteolysis. In the late 70s and early 80s the discovery that the small 76 amino acid protein ubiquitin could be attached to target proteins via a multi-stage process involving ubiquitin-activating enzymes, ubiquitin conjugating enzymes, and ubiquitin ligases, revealed an exciting new post-translational mechanism to regulate protein degradation. This cellular system was uncovered using biochemical methods by Avram Hershko, who would later won the Nobel prize for this discovery; however, the biological functions of ubiquitin ligases remained unknown for many years. It was initially described that... (More)
Protein homeostasis depends on many fundamental processes including mRNA synthesis, translation, post-translational modifications, and proteolysis. In the late 70s and early 80s the discovery that the small 76 amino acid protein ubiquitin could be attached to target proteins via a multi-stage process involving ubiquitin-activating enzymes, ubiquitin conjugating enzymes, and ubiquitin ligases, revealed an exciting new post-translational mechanism to regulate protein degradation. This cellular system was uncovered using biochemical methods by Avram Hershko, who would later won the Nobel prize for this discovery; however, the biological functions of ubiquitin ligases remained unknown for many years. It was initially described that ubiquitin modifies proteins at one or more lysine residues and once a long ubiquitin chain was assembled, proteins were degraded by the proteasome. Now we know that proteins can be mono-, multimono-, homotypic poly-, or heterotypic poly-ubiquitylated, each of which confers a specific signal that goes beyond protein degradation regulating additional key cellular functions such as signal transduction, protein localization, recognition of damaged proteins, etc.
(Less)
- author
- Kaldis, Philipp
LU
and Porter, Lisa A
- organization
- publishing date
- 2024
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Frontiers in Cell and Developmental Biology
- volume
- 12
- article number
- 1458895
- publisher
- Frontiers Media S. A.
- external identifiers
-
- scopus:85202897433
- pmid:39211389
- ISSN
- 2296-634X
- DOI
- 10.3389/fcell.2024.1458895
- language
- English
- LU publication?
- yes
- additional info
- Copyright © 2024 Kaldis and Porter.
- id
- 9393b5d4-ea4c-4b0f-85f1-150f69492e12
- date added to LUP
- 2024-09-09 13:52:32
- date last changed
- 2024-09-11 02:55:19
@article{9393b5d4-ea4c-4b0f-85f1-150f69492e12, abstract = {{<p>Protein homeostasis depends on many fundamental processes including mRNA synthesis, translation, post-translational modifications, and proteolysis. In the late 70s and early 80s the discovery that the small 76 amino acid protein ubiquitin could be attached to target proteins via a multi-stage process involving ubiquitin-activating enzymes, ubiquitin conjugating enzymes, and ubiquitin ligases, revealed an exciting new post-translational mechanism to regulate protein degradation. This cellular system was uncovered using biochemical methods by Avram Hershko, who would later won the Nobel prize for this discovery; however, the biological functions of ubiquitin ligases remained unknown for many years. It was initially described that ubiquitin modifies proteins at one or more lysine residues and once a long ubiquitin chain was assembled, proteins were degraded by the proteasome. Now we know that proteins can be mono-, multimono-, homotypic poly-, or heterotypic poly-ubiquitylated, each of which confers a specific signal that goes beyond protein degradation regulating additional key cellular functions such as signal transduction, protein localization, recognition of damaged proteins, etc.</p>}}, author = {{Kaldis, Philipp and Porter, Lisa A}}, issn = {{2296-634X}}, language = {{eng}}, publisher = {{Frontiers Media S. A.}}, series = {{Frontiers in Cell and Developmental Biology}}, title = {{Regulation of biological processes by ubiquitin ligases: a focus on the Pagano Lab's contribution}}, url = {{http://dx.doi.org/10.3389/fcell.2024.1458895}}, doi = {{10.3389/fcell.2024.1458895}}, volume = {{12}}, year = {{2024}}, }