Alpha-Synuclein Produces Early Behavioral Alterations Via Striatal Cholinergic Synaptic Dysfunction by Interacting with GluN2D N-Methyl-D-Aspartate Receptor Subunit.
(2015) In Biological Psychiatry- Abstract
- Advanced Parkinson's disease (PD) is characterized by massive degeneration of nigral dopaminergic neurons, dramatic motor and cognitive alterations, and presence of nigral Lewy bodies, whose main constituent is α-synuclein (α-syn). However, the synaptic mechanisms underlying behavioral and motor effects induced by early selective overexpression of nigral α-syn are still a matter of debate.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8035442
- author
- organization
- publishing date
- 2015-08-20
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Biological Psychiatry
- publisher
- Elsevier
- external identifiers
-
- pmid:26392130
- scopus:84942038566
- wos:000369370000012
- pmid:26392130
- ISSN
- 0006-3223
- DOI
- 10.1016/j.biopsych.2015.08.013
- language
- English
- LU publication?
- yes
- id
- 93af5305-c04c-471f-803e-98ecea593744 (old id 8035442)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26392130?dopt=Abstract
- date added to LUP
- 2016-04-04 08:04:52
- date last changed
- 2022-05-16 20:52:07
@article{93af5305-c04c-471f-803e-98ecea593744, abstract = {{Advanced Parkinson's disease (PD) is characterized by massive degeneration of nigral dopaminergic neurons, dramatic motor and cognitive alterations, and presence of nigral Lewy bodies, whose main constituent is α-synuclein (α-syn). However, the synaptic mechanisms underlying behavioral and motor effects induced by early selective overexpression of nigral α-syn are still a matter of debate.}}, author = {{Tozzi, Alessandro and de Iure, Antonio and Bagetta, Vincenza and Tantucci, Michela and Durante, Valentina and Quiroga-Varela, Ana and Costa, Cinzia and Di Filippo, Massimiliano and Ghiglieri, Veronica and Latagliata, Emanuele Claudio and Wegrzynowicz, Michal and Decressac, Mickael and Giampà, Carmela and Dalley, Jeffrey W and Xia, Jing and Gardoni, Fabrizio and Mellone, Manuela and El-Agnaf, Omar Mukhtar and Ardah, Mustafa Taleb and Puglisi-Allegra, Stefano and Björklund, Anders and Spillantini, Maria Grazia and Picconi, Barbara and Calabresi, Paolo}}, issn = {{0006-3223}}, language = {{eng}}, month = {{08}}, publisher = {{Elsevier}}, series = {{Biological Psychiatry}}, title = {{Alpha-Synuclein Produces Early Behavioral Alterations Via Striatal Cholinergic Synaptic Dysfunction by Interacting with GluN2D N-Methyl-D-Aspartate Receptor Subunit.}}, url = {{http://dx.doi.org/10.1016/j.biopsych.2015.08.013}}, doi = {{10.1016/j.biopsych.2015.08.013}}, year = {{2015}}, }