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Anterograde and retrograde regulation of nuclear genes encoding mitochondrial proteins during growth, development, and stress

Ng, Sophia; De Clercq, Inge; Van Aken, Olivier LU ; Law, Simon R; Ivanova, Aneta; Willems, Patrick; Giraud, Estelle; Van Breusegem, Frank and Whelan, James (2014) In Molecular Plant 7(7). p.93-1075
Abstract

Mitochondrial biogenesis and function in plants require the expression of over 1000 nuclear genes encoding mitochondrial proteins (NGEMPs). The expression of these genes is regulated by tissue-specific, developmental, internal, and external stimuli that result in a dynamic organelle involved in both metabolic and a variety of signaling processes. Although the metabolic and biosynthetic machinery of mitochondria is relatively well understood, the factors that regulate these processes and the various signaling pathways involved are only beginning to be identified at a molecular level. The molecular components of anterograde (nuclear to mitochondrial) and retrograde (mitochondrial to nuclear) signaling pathways that regulate the expression... (More)

Mitochondrial biogenesis and function in plants require the expression of over 1000 nuclear genes encoding mitochondrial proteins (NGEMPs). The expression of these genes is regulated by tissue-specific, developmental, internal, and external stimuli that result in a dynamic organelle involved in both metabolic and a variety of signaling processes. Although the metabolic and biosynthetic machinery of mitochondria is relatively well understood, the factors that regulate these processes and the various signaling pathways involved are only beginning to be identified at a molecular level. The molecular components of anterograde (nuclear to mitochondrial) and retrograde (mitochondrial to nuclear) signaling pathways that regulate the expression of NGEMPs interact with chloroplast-, growth-, and stress-signaling pathways in the cell at a variety of levels, with common components involved in transmission and execution of these signals. This positions mitochondria as important hubs for signaling in the cell, not only in direct signaling of mitochondrial function per se, but also in sensing and/or integrating a variety of other internal and external signals. This integrates and optimizes growth with energy metabolism and stress responses, which is required in both photosynthetic and non-photosynthetic cells.

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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cell Nucleus, Gene Expression Regulation, Plant, Mitochondrial Proteins, Plant Development, Plants, Stress, Physiological, Journal Article, Research Support, Non-U.S. Gov't, Review
in
Molecular Plant
volume
7
issue
7
pages
19 pages
publisher
Oxford University Press
external identifiers
  • scopus:84904316002
ISSN
1752-9867
DOI
10.1093/mp/ssu037
language
English
LU publication?
no
id
93d7fc01-6df9-4b9b-bff4-63abdd7d8928
date added to LUP
2017-05-09 10:03:42
date last changed
2017-11-19 04:39:49
@article{93d7fc01-6df9-4b9b-bff4-63abdd7d8928,
  abstract     = {<p>Mitochondrial biogenesis and function in plants require the expression of over 1000 nuclear genes encoding mitochondrial proteins (NGEMPs). The expression of these genes is regulated by tissue-specific, developmental, internal, and external stimuli that result in a dynamic organelle involved in both metabolic and a variety of signaling processes. Although the metabolic and biosynthetic machinery of mitochondria is relatively well understood, the factors that regulate these processes and the various signaling pathways involved are only beginning to be identified at a molecular level. The molecular components of anterograde (nuclear to mitochondrial) and retrograde (mitochondrial to nuclear) signaling pathways that regulate the expression of NGEMPs interact with chloroplast-, growth-, and stress-signaling pathways in the cell at a variety of levels, with common components involved in transmission and execution of these signals. This positions mitochondria as important hubs for signaling in the cell, not only in direct signaling of mitochondrial function per se, but also in sensing and/or integrating a variety of other internal and external signals. This integrates and optimizes growth with energy metabolism and stress responses, which is required in both photosynthetic and non-photosynthetic cells.</p>},
  author       = {Ng, Sophia and De Clercq, Inge and Van Aken, Olivier and Law, Simon R and Ivanova, Aneta and Willems, Patrick and Giraud, Estelle and Van Breusegem, Frank and Whelan, James},
  issn         = {1752-9867},
  keyword      = {Cell Nucleus,Gene Expression Regulation, Plant,Mitochondrial Proteins,Plant Development,Plants,Stress, Physiological,Journal Article,Research Support, Non-U.S. Gov't,Review},
  language     = {eng},
  number       = {7},
  pages        = {93--1075},
  publisher    = {Oxford University Press},
  series       = {Molecular Plant},
  title        = {Anterograde and retrograde regulation of nuclear genes encoding mitochondrial proteins during growth, development, and stress},
  url          = {http://dx.doi.org/10.1093/mp/ssu037},
  volume       = {7},
  year         = {2014},
}