Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Gender and birth weight as risk factors for anastomotic stricture after esophageal atresia repair : a systematic review and meta-analysis

Teimourian, Anahid ; Donoso, Felipe ; Stenström, Pernilla LU orcid ; Arnadottir, Helena LU ; Arnbjörnsson, Einar LU ; Lilja, Helene and Salö, Martin LU (2020) In BMC Pediatrics 20.
Abstract

BACKGROUND: Anastomotic stricture (AS) is the most frequently occurring complication that occurs after esophageal atresia (EA) repair. Nevertheless, the pathogenesis remains primarily unknown and there is inadequate knowledge regarding the risk factors for AS. Therefore, a systematic review of the literature and a meta-analysis was performed to investigate whether gender and birth weight were risk factors for the development of AS following EA repair.

METHODS: The main outcome measure was the occurrence of AS. Forest plots with odds ratios (OR) and 95% confidence intervals (CI) were generated for the outcomes. Quality assessment was performed using the Newcastle-Ottawa scale.

RESULTS: Six studies with a total of 495 patients... (More)

BACKGROUND: Anastomotic stricture (AS) is the most frequently occurring complication that occurs after esophageal atresia (EA) repair. Nevertheless, the pathogenesis remains primarily unknown and there is inadequate knowledge regarding the risk factors for AS. Therefore, a systematic review of the literature and a meta-analysis was performed to investigate whether gender and birth weight were risk factors for the development of AS following EA repair.

METHODS: The main outcome measure was the occurrence of AS. Forest plots with odds ratios (OR) and 95% confidence intervals (CI) were generated for the outcomes. Quality assessment was performed using the Newcastle-Ottawa scale.

RESULTS: Six studies with a total of 495 patients were included; 59% males, and 37 and 63% of the patients weighed < 2500 g and ≥ 2500 g, respectively. Male gender (OR, 0.96; 95% CI, 0.66-1.40; p = 0.82) and birth weight < 2500 g (OR, 0.74; 95% CI, 0.47-1.15; p = 0.18) did not increase the risk of AS. The majority of the included studies were retrospective cohort studies and the overall risk of bias was considered to be low to moderate.

CONCLUSION: Neither gender nor birth weight appear to have an impact on the risk of AS development following EA repair.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
BMC Pediatrics
volume
20
article number
400
publisher
BioMed Central (BMC)
external identifiers
  • pmid:32831054
  • scopus:85090070855
ISSN
1471-2431
DOI
10.1186/s12887-020-02295-3
language
English
LU publication?
yes
id
93f832fc-98ce-4cb7-acd8-ab8d16eecfa4
date added to LUP
2020-08-26 07:23:57
date last changed
2024-06-28 00:22:17
@article{93f832fc-98ce-4cb7-acd8-ab8d16eecfa4,
  abstract     = {{<p>BACKGROUND: Anastomotic stricture (AS) is the most frequently occurring complication that occurs after esophageal atresia (EA) repair. Nevertheless, the pathogenesis remains primarily unknown and there is inadequate knowledge regarding the risk factors for AS. Therefore, a systematic review of the literature and a meta-analysis was performed to investigate whether gender and birth weight were risk factors for the development of AS following EA repair.</p><p>METHODS: The main outcome measure was the occurrence of AS. Forest plots with odds ratios (OR) and 95% confidence intervals (CI) were generated for the outcomes. Quality assessment was performed using the Newcastle-Ottawa scale.</p><p>RESULTS: Six studies with a total of 495 patients were included; 59% males, and 37 and 63% of the patients weighed &lt; 2500 g and ≥ 2500 g, respectively. Male gender (OR, 0.96; 95% CI, 0.66-1.40; p = 0.82) and birth weight &lt; 2500 g (OR, 0.74; 95% CI, 0.47-1.15; p = 0.18) did not increase the risk of AS. The majority of the included studies were retrospective cohort studies and the overall risk of bias was considered to be low to moderate.</p><p>CONCLUSION: Neither gender nor birth weight appear to have an impact on the risk of AS development following EA repair.</p>}},
  author       = {{Teimourian, Anahid and Donoso, Felipe and Stenström, Pernilla and Arnadottir, Helena and Arnbjörnsson, Einar and Lilja, Helene and Salö, Martin}},
  issn         = {{1471-2431}},
  language     = {{eng}},
  month        = {{08}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{BMC Pediatrics}},
  title        = {{Gender and birth weight as risk factors for anastomotic stricture after esophageal atresia repair : a systematic review and meta-analysis}},
  url          = {{http://dx.doi.org/10.1186/s12887-020-02295-3}},
  doi          = {{10.1186/s12887-020-02295-3}},
  volume       = {{20}},
  year         = {{2020}},
}