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Horizontal gene transfer: a critical view

Kurland, Charles LU ; Canbäck, Björn LU and Berg, Otto (2003) In Proceedings of the National Academy of Sciences 100(17). p.9658-9662
Abstract
It has been suggested that horizontal gene transfer (HGT) is the "essence of phylogeny." In contrast, much data suggest that this is an exaggeration resulting in part from a reliance on inadequate methods to identify HGT events. In addition, the assumption that HGT is a ubiquitous influence throughout evolution is questionable. Instead, rampant global HGT is likely to have been relevant only to primitive genomes. In modern organisms we suggest that both the range and frequencies of HGT are constrained most often by selective barriers. As a consequence those HGT events that do occur most often have little influence on genome phylogeny. Although HGT does occur with important evolutionary consequences, classical Darwinian lineages seem to be... (More)
It has been suggested that horizontal gene transfer (HGT) is the "essence of phylogeny." In contrast, much data suggest that this is an exaggeration resulting in part from a reliance on inadequate methods to identify HGT events. In addition, the assumption that HGT is a ubiquitous influence throughout evolution is questionable. Instead, rampant global HGT is likely to have been relevant only to primitive genomes. In modern organisms we suggest that both the range and frequencies of HGT are constrained most often by selective barriers. As a consequence those HGT events that do occur most often have little influence on genome phylogeny. Although HGT does occur with important evolutionary consequences, classical Darwinian lineages seem to be the dominant mode of evolution for modern organisms. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Proceedings of the National Academy of Sciences
volume
100
issue
17
pages
9658 - 9662
publisher
National Acad Sciences
external identifiers
  • scopus:0042191905
ISSN
1091-6490
DOI
10.1073/pnas.1632870100
language
English
LU publication?
yes
id
7c775ad7-d44e-4e98-8939-f0d2b5591b04 (old id 945082)
date added to LUP
2008-02-01 11:09:02
date last changed
2018-10-14 03:30:27
@article{7c775ad7-d44e-4e98-8939-f0d2b5591b04,
  abstract     = {It has been suggested that horizontal gene transfer (HGT) is the "essence of phylogeny." In contrast, much data suggest that this is an exaggeration resulting in part from a reliance on inadequate methods to identify HGT events. In addition, the assumption that HGT is a ubiquitous influence throughout evolution is questionable. Instead, rampant global HGT is likely to have been relevant only to primitive genomes. In modern organisms we suggest that both the range and frequencies of HGT are constrained most often by selective barriers. As a consequence those HGT events that do occur most often have little influence on genome phylogeny. Although HGT does occur with important evolutionary consequences, classical Darwinian lineages seem to be the dominant mode of evolution for modern organisms.},
  author       = {Kurland, Charles and Canbäck, Björn and Berg, Otto},
  issn         = {1091-6490},
  language     = {eng},
  number       = {17},
  pages        = {9658--9662},
  publisher    = {National Acad Sciences},
  series       = {Proceedings of the National Academy of Sciences},
  title        = {Horizontal gene transfer: a critical view},
  url          = {http://dx.doi.org/10.1073/pnas.1632870100},
  volume       = {100},
  year         = {2003},
}