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On the origin of mitochondria: a genomics perspective.

Andersson, Siv; Karlberg, Olof; Canbäck, Björn LU and Kurland, Charles LU (2003) In Royal Society of London. Philosophical Transactions B. Biological Sciences 358(1429). p.165-177
Abstract
The availability of complete genome sequence data from both bacteria and eukaryotes provides information about the contribution of bacterial genes to the origin and evolution of mitochondria. Phylogenetic analyses based on genes located in the mitochondrial genome indicate that these genes originated from within the f-proteobacteria. A number of ancestral bacterial genes have also been transferred from the mitochondrial to the nuclear genome, as evidenced by the presence of orthologous genes in the mitochondrial genome in some species and in the nuclear genome of other species. However, a multitude of mitochondrial proteins encoded in the nucleus display no homology to bacterial proteins, indicating that these originated within the... (More)
The availability of complete genome sequence data from both bacteria and eukaryotes provides information about the contribution of bacterial genes to the origin and evolution of mitochondria. Phylogenetic analyses based on genes located in the mitochondrial genome indicate that these genes originated from within the f-proteobacteria. A number of ancestral bacterial genes have also been transferred from the mitochondrial to the nuclear genome, as evidenced by the presence of orthologous genes in the mitochondrial genome in some species and in the nuclear genome of other species. However, a multitude of mitochondrial proteins encoded in the nucleus display no homology to bacterial proteins, indicating that these originated within the eukaryotic cell subsequent to the acquisition of the endosymbiont. An analysis of the expression patterns of yeast nuclear genes coding for mitochondrial proteins has shown that genes predicted to be of eukaryotic origin are mainly translated on polysomes that are free in the cytosol whereas those of putative bacterial origin are translated on polysomes attached to the mitochondrion. The strong relationship with f-proteobacterial genes observed for some mitochondrial genes, combined with the lack of such a relationship for others, indicates that the modern mitochondrial proteome is the product of both reductive and expansive processes. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
respiration, mitochondria, glycolysis, hydrogenosomes, yeast
in
Royal Society of London. Philosophical Transactions B. Biological Sciences
volume
358
issue
1429
pages
165 - 177
publisher
Royal Society
external identifiers
  • scopus:0037471715
ISSN
1471-2970
DOI
10.1098/rstb.2002.1193
language
English
LU publication?
yes
id
19f472cd-2ea2-4e54-a302-1240097e18fb (old id 945092)
date added to LUP
2008-01-24 16:25:44
date last changed
2018-10-14 04:07:13
@article{19f472cd-2ea2-4e54-a302-1240097e18fb,
  abstract     = {The availability of complete genome sequence data from both bacteria and eukaryotes provides information about the contribution of bacterial genes to the origin and evolution of mitochondria. Phylogenetic analyses based on genes located in the mitochondrial genome indicate that these genes originated from within the f-proteobacteria. A number of ancestral bacterial genes have also been transferred from the mitochondrial to the nuclear genome, as evidenced by the presence of orthologous genes in the mitochondrial genome in some species and in the nuclear genome of other species. However, a multitude of mitochondrial proteins encoded in the nucleus display no homology to bacterial proteins, indicating that these originated within the eukaryotic cell subsequent to the acquisition of the endosymbiont. An analysis of the expression patterns of yeast nuclear genes coding for mitochondrial proteins has shown that genes predicted to be of eukaryotic origin are mainly translated on polysomes that are free in the cytosol whereas those of putative bacterial origin are translated on polysomes attached to the mitochondrion. The strong relationship with f-proteobacterial genes observed for some mitochondrial genes, combined with the lack of such a relationship for others, indicates that the modern mitochondrial proteome is the product of both reductive and expansive processes.},
  author       = {Andersson, Siv and Karlberg, Olof and Canbäck, Björn and Kurland, Charles},
  issn         = {1471-2970},
  keyword      = {respiration,mitochondria,glycolysis,hydrogenosomes,yeast},
  language     = {eng},
  number       = {1429},
  pages        = {165--177},
  publisher    = {Royal Society},
  series       = {Royal Society of London. Philosophical Transactions B. Biological Sciences},
  title        = {On the origin of mitochondria: a genomics perspective.},
  url          = {http://dx.doi.org/10.1098/rstb.2002.1193},
  volume       = {358},
  year         = {2003},
}