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Genetic dissection of autoimmune type I diabetes in the BB rat

Jacob, Howard J. ; Pettersson, Anna ; Wilson, Deborah ; Mao, Yipei ; Lernmark, Åke LU and Lander, Eric S. (1992) In Nature Genetics 2(1). p.56-60
Abstract

The BB rat is among the best models of insulin−dependent diabetes mellitus — with onset and pathogenesis closely resembling the human disease. One unusual feature is a severe T−cell lymphopenia, which appears to be inherited as a recessive trait controlled by a single gene, Lyp. Based on genetic analysis of several crosses, we show that development of diabetes involves at least three genes: Lyp, which is tightly linked to the neuropeptide Y (Npy) gene on chromosome 4, a gene linked to the major histocompatibility complex (MHC) on chromosome 20, and a third unmapped gene for which the Fischer rat strain carries an allele conferring resistance.

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author
publishing date
type
Contribution to journal
publication status
published
in
Nature Genetics
volume
2
issue
1
pages
56 - 60
publisher
Nature Publishing Group
external identifiers
  • scopus:0026922594
  • pmid:1303251
ISSN
1061-4036
DOI
10.1038/ng0992-56
language
English
LU publication?
no
id
94618191-25f6-4338-9338-1f18050fa9e7
date added to LUP
2019-09-11 09:31:28
date last changed
2020-05-24 06:25:32
@article{94618191-25f6-4338-9338-1f18050fa9e7,
  abstract     = {<p>The BB rat is among the best models of insulin−dependent diabetes mellitus — with onset and pathogenesis closely resembling the human disease. One unusual feature is a severe T−cell lymphopenia, which appears to be inherited as a recessive trait controlled by a single gene, Lyp. Based on genetic analysis of several crosses, we show that development of diabetes involves at least three genes: Lyp, which is tightly linked to the neuropeptide Y (Npy) gene on chromosome 4, a gene linked to the major histocompatibility complex (MHC) on chromosome 20, and a third unmapped gene for which the Fischer rat strain carries an allele conferring resistance.</p>},
  author       = {Jacob, Howard J. and Pettersson, Anna and Wilson, Deborah and Mao, Yipei and Lernmark, Åke and Lander, Eric S.},
  issn         = {1061-4036},
  language     = {eng},
  month        = {01},
  number       = {1},
  pages        = {56--60},
  publisher    = {Nature Publishing Group},
  series       = {Nature Genetics},
  title        = {Genetic dissection of autoimmune type I diabetes in the BB rat},
  url          = {http://dx.doi.org/10.1038/ng0992-56},
  doi          = {10.1038/ng0992-56},
  volume       = {2},
  year         = {1992},
}