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Genetic dissection of autoimmune type I diabetes in the BB rat

Jacob, Howard J. ; Pettersson, Anna ; Wilson, Deborah ; Mao, Yipei ; Lernmark, Åke LU orcid and Lander, Eric S. (1992) In Nature Genetics 2(1). p.56-60
Abstract

The BB rat is among the best models of insulin−dependent diabetes mellitus — with onset and pathogenesis closely resembling the human disease. One unusual feature is a severe T−cell lymphopenia, which appears to be inherited as a recessive trait controlled by a single gene, Lyp. Based on genetic analysis of several crosses, we show that development of diabetes involves at least three genes: Lyp, which is tightly linked to the neuropeptide Y (Npy) gene on chromosome 4, a gene linked to the major histocompatibility complex (MHC) on chromosome 20, and a third unmapped gene for which the Fischer rat strain carries an allele conferring resistance.

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author
; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
in
Nature Genetics
volume
2
issue
1
pages
56 - 60
publisher
Nature Publishing Group
external identifiers
  • pmid:1303251
  • scopus:0026922594
ISSN
1061-4036
DOI
10.1038/ng0992-56
language
English
LU publication?
no
id
94618191-25f6-4338-9338-1f18050fa9e7
date added to LUP
2019-09-11 09:31:28
date last changed
2024-03-13 08:21:28
@article{94618191-25f6-4338-9338-1f18050fa9e7,
  abstract     = {{<p>The BB rat is among the best models of insulin−dependent diabetes mellitus — with onset and pathogenesis closely resembling the human disease. One unusual feature is a severe T−cell lymphopenia, which appears to be inherited as a recessive trait controlled by a single gene, Lyp. Based on genetic analysis of several crosses, we show that development of diabetes involves at least three genes: Lyp, which is tightly linked to the neuropeptide Y (Npy) gene on chromosome 4, a gene linked to the major histocompatibility complex (MHC) on chromosome 20, and a third unmapped gene for which the Fischer rat strain carries an allele conferring resistance.</p>}},
  author       = {{Jacob, Howard J. and Pettersson, Anna and Wilson, Deborah and Mao, Yipei and Lernmark, Åke and Lander, Eric S.}},
  issn         = {{1061-4036}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{1}},
  pages        = {{56--60}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Nature Genetics}},
  title        = {{Genetic dissection of autoimmune type I diabetes in the BB rat}},
  url          = {{http://dx.doi.org/10.1038/ng0992-56}},
  doi          = {{10.1038/ng0992-56}},
  volume       = {{2}},
  year         = {{1992}},
}