Three Decades of Research about the Corona Around Nanoparticles : Lessons Learned and Where to Go Now
(2020) In Small 16(46).- Abstract
The research about how a nanoparticle (NP) interacts with a complex biological solution has been conducted, according to the literature, for almost three decades. A significant amount of data has been generated, especially in the last one and a half decade. First, it became its own research field which was later divided into many subresearch fields. This outlook does not aim to be a comprehensive review of the field or any of its subresearch fields. There is too much data published to attempt that. Instead, here it has been tried to highlight what, in the opinion, is the main step taken during these three decades. Thereafter, the weaknesses and end are pointed out with what needs to be the main focus for the future to understand the... (More)
The research about how a nanoparticle (NP) interacts with a complex biological solution has been conducted, according to the literature, for almost three decades. A significant amount of data has been generated, especially in the last one and a half decade. First, it became its own research field which was later divided into many subresearch fields. This outlook does not aim to be a comprehensive review of the field or any of its subresearch fields. There is too much data published to attempt that. Instead, here it has been tried to highlight what, in the opinion, is the main step taken during these three decades. Thereafter, the weaknesses and end are pointed out with what needs to be the main focus for the future to understand the protein corona formation in the bloodstream, which is a prerequisite for the developing of true target specific drug-delivering nanoparticles.
(Less)
- author
- Lundqvist, Martin LU and Cedervall, Tommy LU
- organization
- publishing date
- 2020-11-19
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- adsorption, blood, corona, delivery, lipid, nanoparticles, proteins
- in
- Small
- volume
- 16
- issue
- 46
- article number
- 2000892
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:33107223
- scopus:85094564120
- ISSN
- 1613-6810
- DOI
- 10.1002/smll.202000892
- language
- English
- LU publication?
- yes
- id
- 94846acd-801a-4478-a87f-3def07110b0b
- date added to LUP
- 2020-11-17 14:17:48
- date last changed
- 2024-06-14 02:46:49
@article{94846acd-801a-4478-a87f-3def07110b0b,
abstract = {{<p>The research about how a nanoparticle (NP) interacts with a complex biological solution has been conducted, according to the literature, for almost three decades. A significant amount of data has been generated, especially in the last one and a half decade. First, it became its own research field which was later divided into many subresearch fields. This outlook does not aim to be a comprehensive review of the field or any of its subresearch fields. There is too much data published to attempt that. Instead, here it has been tried to highlight what, in the opinion, is the main step taken during these three decades. Thereafter, the weaknesses and end are pointed out with what needs to be the main focus for the future to understand the protein corona formation in the bloodstream, which is a prerequisite for the developing of true target specific drug-delivering nanoparticles.</p>}},
author = {{Lundqvist, Martin and Cedervall, Tommy}},
issn = {{1613-6810}},
keywords = {{adsorption; blood; corona; delivery; lipid; nanoparticles; proteins}},
language = {{eng}},
month = {{11}},
number = {{46}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Small}},
title = {{Three Decades of Research about the Corona Around Nanoparticles : Lessons Learned and Where to Go Now}},
url = {{http://dx.doi.org/10.1002/smll.202000892}},
doi = {{10.1002/smll.202000892}},
volume = {{16}},
year = {{2020}},
}