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Three Decades of Research about the Corona Around Nanoparticles : Lessons Learned and Where to Go Now

Lundqvist, Martin LU and Cedervall, Tommy LU (2020) In Small 16(46).
Abstract

The research about how a nanoparticle (NP) interacts with a complex biological solution has been conducted, according to the literature, for almost three decades. A significant amount of data has been generated, especially in the last one and a half decade. First, it became its own research field which was later divided into many subresearch fields. This outlook does not aim to be a comprehensive review of the field or any of its subresearch fields. There is too much data published to attempt that. Instead, here it has been tried to highlight what, in the opinion, is the main step taken during these three decades. Thereafter, the weaknesses and end are pointed out with what needs to be the main focus for the future to understand the... (More)

The research about how a nanoparticle (NP) interacts with a complex biological solution has been conducted, according to the literature, for almost three decades. A significant amount of data has been generated, especially in the last one and a half decade. First, it became its own research field which was later divided into many subresearch fields. This outlook does not aim to be a comprehensive review of the field or any of its subresearch fields. There is too much data published to attempt that. Instead, here it has been tried to highlight what, in the opinion, is the main step taken during these three decades. Thereafter, the weaknesses and end are pointed out with what needs to be the main focus for the future to understand the protein corona formation in the bloodstream, which is a prerequisite for the developing of true target specific drug-delivering nanoparticles.

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author
and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
adsorption, blood, corona, delivery, lipid, nanoparticles, proteins
in
Small
volume
16
issue
46
article number
2000892
publisher
John Wiley and Sons
external identifiers
  • scopus:85094564120
  • pmid:33107223
ISSN
1613-6810
DOI
10.1002/smll.202000892
language
English
LU publication?
yes
id
94846acd-801a-4478-a87f-3def07110b0b
date added to LUP
2020-11-17 14:17:48
date last changed
2021-01-06 06:53:32
@article{94846acd-801a-4478-a87f-3def07110b0b,
  abstract     = {<p>The research about how a nanoparticle (NP) interacts with a complex biological solution has been conducted, according to the literature, for almost three decades. A significant amount of data has been generated, especially in the last one and a half decade. First, it became its own research field which was later divided into many subresearch fields. This outlook does not aim to be a comprehensive review of the field or any of its subresearch fields. There is too much data published to attempt that. Instead, here it has been tried to highlight what, in the opinion, is the main step taken during these three decades. Thereafter, the weaknesses and end are pointed out with what needs to be the main focus for the future to understand the protein corona formation in the bloodstream, which is a prerequisite for the developing of true target specific drug-delivering nanoparticles.</p>},
  author       = {Lundqvist, Martin and Cedervall, Tommy},
  issn         = {1613-6810},
  language     = {eng},
  month        = {11},
  number       = {46},
  publisher    = {John Wiley and Sons},
  series       = {Small},
  title        = {Three Decades of Research about the Corona Around Nanoparticles : Lessons Learned and Where to Go Now},
  url          = {http://dx.doi.org/10.1002/smll.202000892},
  doi          = {10.1002/smll.202000892},
  volume       = {16},
  year         = {2020},
}