Inhibition of mitogen-activated protein kinase 1/2 in the acute phase of stroke improves long-term neurological outcome and promotes recovery processes in rats.
(2015) In Acta Physiologica- Abstract
- Extracellular signal-regulated kinase (ERK) 1/2 is activated during acute phase of stroke and contributes to stroke pathology. We have found that acute treatment with MEK1/2 inhibitors decrease infarct size and neurological deficits two days after experimental stroke. However it is not known whether benefits of this inhibition persist long-term. Therefore, the aim of this study was to assess neurological function, infarct size and recovery processes 14 days after stroke in male rats to determine long-term outcome following acute treatment with the MEK1/2 inhibitor U0126.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8234885
- author
- Mostajeran, Maryam LU ; Edvinsson, Lars LU ; Warfvinge, Karin LU ; Singh, Rushani and Ansar, Saema LU
- organization
- publishing date
- 2015-11-23
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Acta Physiologica
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:26595054
- pmid:26595054
- wos:000397504700015
- scopus:84983164461
- ISSN
- 1748-1716
- DOI
- 10.1111/apha.12632
- language
- English
- LU publication?
- yes
- id
- 948cb383-d36b-4160-881d-b1d7ffa7d788 (old id 8234885)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/26595054?dopt=Abstract
- date added to LUP
- 2016-04-04 08:47:34
- date last changed
- 2022-04-15 20:51:26
@article{948cb383-d36b-4160-881d-b1d7ffa7d788, abstract = {{Extracellular signal-regulated kinase (ERK) 1/2 is activated during acute phase of stroke and contributes to stroke pathology. We have found that acute treatment with MEK1/2 inhibitors decrease infarct size and neurological deficits two days after experimental stroke. However it is not known whether benefits of this inhibition persist long-term. Therefore, the aim of this study was to assess neurological function, infarct size and recovery processes 14 days after stroke in male rats to determine long-term outcome following acute treatment with the MEK1/2 inhibitor U0126.}}, author = {{Mostajeran, Maryam and Edvinsson, Lars and Warfvinge, Karin and Singh, Rushani and Ansar, Saema}}, issn = {{1748-1716}}, language = {{eng}}, month = {{11}}, publisher = {{Wiley-Blackwell}}, series = {{Acta Physiologica}}, title = {{Inhibition of mitogen-activated protein kinase 1/2 in the acute phase of stroke improves long-term neurological outcome and promotes recovery processes in rats.}}, url = {{http://dx.doi.org/10.1111/apha.12632}}, doi = {{10.1111/apha.12632}}, year = {{2015}}, }