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Inhibition of mitogen-activated protein kinase 1/2 in the acute phase of stroke improves long-term neurological outcome and promotes recovery processes in rats.

Mostajeran, Maryam LU ; Edvinsson, Lars LU ; Warfvinge, Karin LU orcid ; Singh, Rushani and Ansar, Saema LU (2015) In Acta Physiologica
Abstract
Extracellular signal-regulated kinase (ERK) 1/2 is activated during acute phase of stroke and contributes to stroke pathology. We have found that acute treatment with MEK1/2 inhibitors decrease infarct size and neurological deficits two days after experimental stroke. However it is not known whether benefits of this inhibition persist long-term. Therefore, the aim of this study was to assess neurological function, infarct size and recovery processes 14 days after stroke in male rats to determine long-term outcome following acute treatment with the MEK1/2 inhibitor U0126.
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Physiologica
publisher
Wiley-Blackwell
external identifiers
  • pmid:26595054
  • pmid:26595054
  • wos:000397504700015
  • scopus:84983164461
ISSN
1748-1716
DOI
10.1111/apha.12632
language
English
LU publication?
yes
id
948cb383-d36b-4160-881d-b1d7ffa7d788 (old id 8234885)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26595054?dopt=Abstract
date added to LUP
2016-04-04 08:47:34
date last changed
2025-10-14 11:48:54
@article{948cb383-d36b-4160-881d-b1d7ffa7d788,
  abstract     = {{Extracellular signal-regulated kinase (ERK) 1/2 is activated during acute phase of stroke and contributes to stroke pathology. We have found that acute treatment with MEK1/2 inhibitors decrease infarct size and neurological deficits two days after experimental stroke. However it is not known whether benefits of this inhibition persist long-term. Therefore, the aim of this study was to assess neurological function, infarct size and recovery processes 14 days after stroke in male rats to determine long-term outcome following acute treatment with the MEK1/2 inhibitor U0126.}},
  author       = {{Mostajeran, Maryam and Edvinsson, Lars and Warfvinge, Karin and Singh, Rushani and Ansar, Saema}},
  issn         = {{1748-1716}},
  language     = {{eng}},
  month        = {{11}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Acta Physiologica}},
  title        = {{Inhibition of mitogen-activated protein kinase 1/2 in the acute phase of stroke improves long-term neurological outcome and promotes recovery processes in rats.}},
  url          = {{http://dx.doi.org/10.1111/apha.12632}},
  doi          = {{10.1111/apha.12632}},
  year         = {{2015}},
}