Head-to-head study of diagnostic accuracy of plasma and cerebrospinal fluid p-tau217 versus p-tau181 and p-tau231 in a memory clinic cohort
(2024) In Journal of Neurology- Abstract
Background and objective: Phosphorylated tau (p-tau) 217 has recently received attention because it seems more reliable than other p-tau variants for identifying Alzheimer’s disease (AD) pathology. Thus, we aimed to compare the diagnostic accuracy of plasma and CSF p-tau217 with p-tau181 and p-tau231 in a memory clinic cohort. Methods: The study included 114 participants (CU = 33; MCI = 67; Dementia = 14). The p-tau variants were correlated versus continuous measures of amyloid (A) and tau (T)-PET. The p-tau phospho-epitopes were assessed through: (i) effect sizes (δ) between diagnostic and A ± and T ± groups; (ii) receiver operating characteristic (ROC) analyses in A-PET and T-PET. Results: The correlations between both plasma and CSF... (More)
Background and objective: Phosphorylated tau (p-tau) 217 has recently received attention because it seems more reliable than other p-tau variants for identifying Alzheimer’s disease (AD) pathology. Thus, we aimed to compare the diagnostic accuracy of plasma and CSF p-tau217 with p-tau181 and p-tau231 in a memory clinic cohort. Methods: The study included 114 participants (CU = 33; MCI = 67; Dementia = 14). The p-tau variants were correlated versus continuous measures of amyloid (A) and tau (T)-PET. The p-tau phospho-epitopes were assessed through: (i) effect sizes (δ) between diagnostic and A ± and T ± groups; (ii) receiver operating characteristic (ROC) analyses in A-PET and T-PET. Results: The correlations between both plasma and CSF p-tau217 with A-PET and T-PET (r range 0.64–0.83) were stronger than those of p-tau181 (r range 0.44–0.79) and p-tau231 (r range 0.46–0.76). Plasma p-tau217 showed significantly higher diagnostic accuracy than p-tau181 and p-tau231 in (i) differences between diagnostic and biomarker groups (δ range: p-tau217 = 0.55–0.96; p-tau181 = 0.51–0.67; p-tau231 = 0.53–0.71); (ii) ROC curves to identify A-PET and T-PET positivity (AUCaverage: p-tau217 = 0.96; p-tau181 = 0.76; p-tau231 = 0.79). On the other hand, CSF p-tau217 (AUCaverage = 0.95) did not reveal significant differences in A-PET and T-PET AUC than p-tau181 (AUCaverage = 0.88) and p-tau231 (AUCaverage = 0.89). Discussion: Plasma p-tau217 demonstrated better performance in the identification of AD pathology and clinical phenotypes in comparison with other variants of p-tau in a memory clinic cohort. Furthermore, p-tau217 had comparable performance in plasma and CSF. Our findings suggest the potential of plasma p-tau217 in the diagnosis and screening for AD, which could allow for a decreased use of invasive biomarkers in the future.
(Less)
- author
- Mendes, Augusto J.
; Ribaldi, Federica
; Lathuiliere, Aurelien
; Ashton, Nicholas J.
; Janelidze, Shorena
LU
; Zetterberg, Henrik
LU
; Scheffler, Max
; Assal, Frédéric
; Garibotto, Valentina
; Blennow, Kaj
LU
; Hansson, Oskar
LU
and Frisoni, Giovanni B.
(Less) - organization
- publishing date
- 2024
- type
- Contribution to journal
- publication status
- epub
- subject
- keywords
- Alzheimer’s disease, Amyloid, CSF, p-tau, Plasma, Tau
- in
- Journal of Neurology
- publisher
- Springer
- external identifiers
-
- pmid:38195896
- scopus:85181728204
- ISSN
- 0340-5354
- DOI
- 10.1007/s00415-023-12148-5
- language
- English
- LU publication?
- yes
- id
- 9490928a-a74c-47e9-8a69-0bd0baf18faf
- date added to LUP
- 2024-02-06 14:59:17
- date last changed
- 2024-04-23 16:04:33
@article{9490928a-a74c-47e9-8a69-0bd0baf18faf,
abstract = {{<p>Background and objective: Phosphorylated tau (p-tau) 217 has recently received attention because it seems more reliable than other p-tau variants for identifying Alzheimer’s disease (AD) pathology. Thus, we aimed to compare the diagnostic accuracy of plasma and CSF p-tau217 with p-tau181 and p-tau231 in a memory clinic cohort. Methods: The study included 114 participants (CU = 33; MCI = 67; Dementia = 14). The p-tau variants were correlated versus continuous measures of amyloid (A) and tau (T)-PET. The p-tau phospho-epitopes were assessed through: (i) effect sizes (δ) between diagnostic and A ± and T ± groups; (ii) receiver operating characteristic (ROC) analyses in A-PET and T-PET. Results: The correlations between both plasma and CSF p-tau217 with A-PET and T-PET (r range 0.64–0.83) were stronger than those of p-tau181 (r range 0.44–0.79) and p-tau231 (r range 0.46–0.76). Plasma p-tau217 showed significantly higher diagnostic accuracy than p-tau181 and p-tau231 in (i) differences between diagnostic and biomarker groups (δ <sub>range</sub>: p-tau217 = 0.55–0.96; p-tau181 = 0.51–0.67; p-tau231 = 0.53–0.71); (ii) ROC curves to identify A-PET and T-PET positivity (AUC<sub>average</sub>: p-tau217 = 0.96; p-tau181 = 0.76; p-tau231 = 0.79). On the other hand, CSF p-tau217 (AUC<sub>average</sub> = 0.95) did not reveal significant differences in A-PET and T-PET AUC than p-tau181 (AUC<sub>average</sub> = 0.88) and p-tau231 (AUC<sub>average</sub> = 0.89). Discussion: Plasma p-tau217 demonstrated better performance in the identification of AD pathology and clinical phenotypes in comparison with other variants of p-tau in a memory clinic cohort. Furthermore, p-tau217 had comparable performance in plasma and CSF. Our findings suggest the potential of plasma p-tau217 in the diagnosis and screening for AD, which could allow for a decreased use of invasive biomarkers in the future.</p>}},
author = {{Mendes, Augusto J. and Ribaldi, Federica and Lathuiliere, Aurelien and Ashton, Nicholas J. and Janelidze, Shorena and Zetterberg, Henrik and Scheffler, Max and Assal, Frédéric and Garibotto, Valentina and Blennow, Kaj and Hansson, Oskar and Frisoni, Giovanni B.}},
issn = {{0340-5354}},
keywords = {{Alzheimer’s disease; Amyloid; CSF; p-tau; Plasma; Tau}},
language = {{eng}},
publisher = {{Springer}},
series = {{Journal of Neurology}},
title = {{Head-to-head study of diagnostic accuracy of plasma and cerebrospinal fluid p-tau217 versus p-tau181 and p-tau231 in a memory clinic cohort}},
url = {{http://dx.doi.org/10.1007/s00415-023-12148-5}},
doi = {{10.1007/s00415-023-12148-5}},
year = {{2024}},
}