Epigenome-wide association study of serum folate in maternal peripheral blood leukocytes
(2023) In Epigenomics 15(1). p.39-52- Abstract
Aim: To perform an epigenome-wide association study (EWAS) of serum folate in maternal blood. Methods: Cross-ancestry (Europeans = 302, South Asians = 161) and ancestry-specific EWAS in the EPIPREG cohort were performed, followed by methyl quantitative trait loci analysis and association with cardiometabolic phenotypes. Replication was attempted using maternal folate intake and blood methylation data from the MoBa study and verified if the findings were significant in a previous EWAS of maternal serum folate in cord blood. Results & conclusion: cg19888088 (cross-ancestry) in EBF3, cg01952260 (Europeans) and cg07077240 (South Asians) in HERC3 were associated with serum folate. cg19888088 and cg01952260 were associated with diastolic... (More)
Aim: To perform an epigenome-wide association study (EWAS) of serum folate in maternal blood. Methods: Cross-ancestry (Europeans = 302, South Asians = 161) and ancestry-specific EWAS in the EPIPREG cohort were performed, followed by methyl quantitative trait loci analysis and association with cardiometabolic phenotypes. Replication was attempted using maternal folate intake and blood methylation data from the MoBa study and verified if the findings were significant in a previous EWAS of maternal serum folate in cord blood. Results & conclusion: cg19888088 (cross-ancestry) in EBF3, cg01952260 (Europeans) and cg07077240 (South Asians) in HERC3 were associated with serum folate. cg19888088 and cg01952260 were associated with diastolic blood pressure. cg07077240 was associated with variants in CASC15. The findings were not replicated and were not significant in cord blood.
(Less)
- author
- organization
- publishing date
- 2023-03-28
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Epigenomics
- volume
- 15
- issue
- 1
- pages
- 39 - 52
- publisher
- Future Medicine Ltd.
- external identifiers
-
- scopus:85151573562
- pmid:36974632
- ISSN
- 1750-192X
- DOI
- 10.2217/epi-2022-0427
- language
- English
- LU publication?
- yes
- id
- 94b87faf-6689-473d-9f06-12446109ea6e
- date added to LUP
- 2023-03-29 21:29:45
- date last changed
- 2024-04-19 20:34:21
@article{94b87faf-6689-473d-9f06-12446109ea6e, abstract = {{<p>Aim: To perform an epigenome-wide association study (EWAS) of serum folate in maternal blood. Methods: Cross-ancestry (Europeans = 302, South Asians = 161) and ancestry-specific EWAS in the EPIPREG cohort were performed, followed by methyl quantitative trait loci analysis and association with cardiometabolic phenotypes. Replication was attempted using maternal folate intake and blood methylation data from the MoBa study and verified if the findings were significant in a previous EWAS of maternal serum folate in cord blood. Results & conclusion: cg19888088 (cross-ancestry) in EBF3, cg01952260 (Europeans) and cg07077240 (South Asians) in HERC3 were associated with serum folate. cg19888088 and cg01952260 were associated with diastolic blood pressure. cg07077240 was associated with variants in CASC15. The findings were not replicated and were not significant in cord blood.</p>}}, author = {{Fragoso-Bargas, Nicolas and Page, Christian M and Joubert, Bonnie R and London, Stephanie J and Lee-Ødegård, Sindre and Opsahl, Julia O and Sletner, Line and Jenum, Anne K and Qvigstad, Elisabeth and Prasad, Rashmi B and Moen, Gunn-Helen and Birkeland, Kåre I and Sommer, Christine}}, issn = {{1750-192X}}, language = {{eng}}, month = {{03}}, number = {{1}}, pages = {{39--52}}, publisher = {{Future Medicine Ltd.}}, series = {{Epigenomics}}, title = {{Epigenome-wide association study of serum folate in maternal peripheral blood leukocytes}}, url = {{http://dx.doi.org/10.2217/epi-2022-0427}}, doi = {{10.2217/epi-2022-0427}}, volume = {{15}}, year = {{2023}}, }