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Epigenome-wide association study of serum folate in maternal peripheral blood leukocytes

Fragoso-Bargas, Nicolas LU ; Page, Christian M ; Joubert, Bonnie R ; London, Stephanie J ; Lee-Ødegård, Sindre ; Opsahl, Julia O ; Sletner, Line ; Jenum, Anne K ; Qvigstad, Elisabeth and Prasad, Rashmi B LU , et al. (2023) In Epigenomics 15(1). p.39-52
Abstract

Aim: To perform an epigenome-wide association study (EWAS) of serum folate in maternal blood. Methods: Cross-ancestry (Europeans = 302, South Asians = 161) and ancestry-specific EWAS in the EPIPREG cohort were performed, followed by methyl quantitative trait loci analysis and association with cardiometabolic phenotypes. Replication was attempted using maternal folate intake and blood methylation data from the MoBa study and verified if the findings were significant in a previous EWAS of maternal serum folate in cord blood. Results & conclusion: cg19888088 (cross-ancestry) in EBF3, cg01952260 (Europeans) and cg07077240 (South Asians) in HERC3 were associated with serum folate. cg19888088 and cg01952260 were associated with diastolic... (More)

Aim: To perform an epigenome-wide association study (EWAS) of serum folate in maternal blood. Methods: Cross-ancestry (Europeans = 302, South Asians = 161) and ancestry-specific EWAS in the EPIPREG cohort were performed, followed by methyl quantitative trait loci analysis and association with cardiometabolic phenotypes. Replication was attempted using maternal folate intake and blood methylation data from the MoBa study and verified if the findings were significant in a previous EWAS of maternal serum folate in cord blood. Results & conclusion: cg19888088 (cross-ancestry) in EBF3, cg01952260 (Europeans) and cg07077240 (South Asians) in HERC3 were associated with serum folate. cg19888088 and cg01952260 were associated with diastolic blood pressure. cg07077240 was associated with variants in CASC15. The findings were not replicated and were not significant in cord blood.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Epigenomics
volume
15
issue
1
pages
39 - 52
publisher
Future Medicine Ltd.
external identifiers
  • scopus:85151573562
  • pmid:36974632
ISSN
1750-192X
DOI
10.2217/epi-2022-0427
language
English
LU publication?
yes
id
94b87faf-6689-473d-9f06-12446109ea6e
date added to LUP
2023-03-29 21:29:45
date last changed
2024-04-19 20:34:21
@article{94b87faf-6689-473d-9f06-12446109ea6e,
  abstract     = {{<p>Aim: To perform an epigenome-wide association study (EWAS) of serum folate in maternal blood. Methods: Cross-ancestry (Europeans = 302, South Asians = 161) and ancestry-specific EWAS in the EPIPREG cohort were performed, followed by methyl quantitative trait loci analysis and association with cardiometabolic phenotypes. Replication was attempted using maternal folate intake and blood methylation data from the MoBa study and verified if the findings were significant in a previous EWAS of maternal serum folate in cord blood. Results &amp; conclusion: cg19888088 (cross-ancestry) in EBF3, cg01952260 (Europeans) and cg07077240 (South Asians) in HERC3 were associated with serum folate. cg19888088 and cg01952260 were associated with diastolic blood pressure. cg07077240 was associated with variants in CASC15. The findings were not replicated and were not significant in cord blood.</p>}},
  author       = {{Fragoso-Bargas, Nicolas and Page, Christian M and Joubert, Bonnie R and London, Stephanie J and Lee-Ødegård, Sindre and Opsahl, Julia O and Sletner, Line and Jenum, Anne K and Qvigstad, Elisabeth and Prasad, Rashmi B and Moen, Gunn-Helen and Birkeland, Kåre I and Sommer, Christine}},
  issn         = {{1750-192X}},
  language     = {{eng}},
  month        = {{03}},
  number       = {{1}},
  pages        = {{39--52}},
  publisher    = {{Future Medicine Ltd.}},
  series       = {{Epigenomics}},
  title        = {{Epigenome-wide association study of serum folate in maternal peripheral blood leukocytes}},
  url          = {{http://dx.doi.org/10.2217/epi-2022-0427}},
  doi          = {{10.2217/epi-2022-0427}},
  volume       = {{15}},
  year         = {{2023}},
}