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Study protocol : Differential effects of diet and physical activity based interventions in pregnancy on maternal and fetal outcomes: Individual patient data (IPD) meta-analysis and health economic evaluation

Ruifrok, Anneloes E; Rogozinska, Ewelina; van Poppel, Mireille N M; Rayanagoudar, Girish; Kerry, Sally; de Groot, Christianne J M; Yeo, Seon Ae; Molyneaux, Emma; Barakat Carballo, Ruben and Perales, Maria, et al. (2014) In Systematic Reviews 3.
Abstract
Background

Pregnant women who gain excess weight are at risk of complications during pregnancy and in the long term. Interventions based on diet and physical activity minimise gestational weight gain with varied effect on clinical outcomes. The effect of interventions on varied groups of women based on body mass index, age, ethnicity, socioeconomic status, parity, and underlying medical conditions is not clear. Our individual patient data (IPD) meta-analysis of randomised trials will assess the differential effect of diet- and physical activity-based interventions on maternal weight gain and pregnancy outcomes in clinically relevant subgroups of women.
Methods/design
(More)
Background

Pregnant women who gain excess weight are at risk of complications during pregnancy and in the long term. Interventions based on diet and physical activity minimise gestational weight gain with varied effect on clinical outcomes. The effect of interventions on varied groups of women based on body mass index, age, ethnicity, socioeconomic status, parity, and underlying medical conditions is not clear. Our individual patient data (IPD) meta-analysis of randomised trials will assess the differential effect of diet- and physical activity-based interventions on maternal weight gain and pregnancy outcomes in clinically relevant subgroups of women.
Methods/design

Randomised trials on diet and physical activity in pregnancy will be identified by searching the following databases: MEDLINE, EMBASE, BIOSIS, LILACS, Pascal, Science Citation Index, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, Database of Abstracts of Reviews of Effects, and Health Technology Assessment Database. Primary researchers of the identified trials are invited to join the International Weight Management in Pregnancy Collaborative Network and share their individual patient data. We will reanalyse each study separately and confirm the findings with the original authors. Then, for each intervention type and outcome, we will perform as appropriate either a one-step or a two-step IPD meta-analysis to obtain summary estimates of effects and 95% confidence intervals, for all women combined and for each subgroup of interest. The primary outcomes are gestational weight gain and composite adverse maternal and fetal outcomes. The difference in effects between subgroups will be estimated and between-study heterogeneity suitably quantified and explored. The potential for publication bias and availability bias in the IPD obtained will be investigated. We will conduct a model-based economic evaluation to assess the cost effectiveness of the interventions to manage weight gain in pregnancy and undertake a value of information analysis to inform future research. (Less)
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publication status
published
in
Systematic Reviews
volume
3
publisher
BioMed Central
external identifiers
  • scopus:84939154975
ISSN
2046-4053
DOI
10.1186/2046-4053-3-131
language
English
LU publication?
yes
id
94ca3163-55ff-4682-8577-19627bdff628
date added to LUP
2017-02-03 10:39:24
date last changed
2017-08-08 14:13:48
@article{94ca3163-55ff-4682-8577-19627bdff628,
  abstract     = {Background<br clear="none"/><br clear="none"/>Pregnant women who gain excess weight are at risk of complications during pregnancy and in the long term. Interventions based on diet and physical activity minimise gestational weight gain with varied effect on clinical outcomes. The effect of interventions on varied groups of women based on body mass index, age, ethnicity, socioeconomic status, parity, and underlying medical conditions is not clear. Our individual patient data (IPD) meta-analysis of randomised trials will assess the differential effect of diet- and physical activity-based interventions on maternal weight gain and pregnancy outcomes in clinically relevant subgroups of women.<br clear="none"/>Methods/design<br clear="none"/><br clear="none"/>Randomised trials on diet and physical activity in pregnancy will be identified by searching the following databases: MEDLINE, EMBASE, BIOSIS, LILACS, Pascal, Science Citation Index, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, Database of Abstracts of Reviews of Effects, and Health Technology Assessment Database. Primary researchers of the identified trials are invited to join the International Weight Management in Pregnancy Collaborative Network and share their individual patient data. We will reanalyse each study separately and confirm the findings with the original authors. Then, for each intervention type and outcome, we will perform as appropriate either a one-step or a two-step IPD meta-analysis to obtain summary estimates of effects and 95% confidence intervals, for all women combined and for each subgroup of interest. The primary outcomes are gestational weight gain and composite adverse maternal and fetal outcomes. The difference in effects between subgroups will be estimated and between-study heterogeneity suitably quantified and explored. The potential for publication bias and availability bias in the IPD obtained will be investigated. We will conduct a model-based economic evaluation to assess the cost effectiveness of the interventions to manage weight gain in pregnancy and undertake a value of information analysis to inform future research.},
  articleno    = {131},
  author       = {Ruifrok, Anneloes E and Rogozinska, Ewelina and van Poppel, Mireille N M and Rayanagoudar, Girish and Kerry, Sally and de Groot, Christianne J M and Yeo, Seon Ae and Molyneaux, Emma and Barakat Carballo, Ruben and Perales, Maria and Bogaerts, Annick and Cecatti, Jose G and Surita, Fernanda and Dodd, Jodie and Owens, Julie and El Beltagy, Nermeen and Devlieger, Roland and Teede, Helena and Harrison, Cheryce and Haakstad, Lene and Shen, Garry X and Shub, Alexis and Motahari, Narges and Khoury, Janette and Tonstad, Serena and Luoto, Riitta and Kinnunen, Tarja I and Guelfi, Kym and Facchinetti, Fabio and Petrella, Elisabetta and Phelan, Suzanne and Scudeller, Tânia T and Rauh, Kathrin and Hauner, Hans and Renault, Kristina and Sagedal, Linda Reme and Vistad, Ingvild and Stafne, Signe Nilssen and Mørkved, Siv and Salvesen, Kjell Åsmund and Vinter, Christina and Vitolo, Marcia and Astrup, Arne and Geiker, Nina Rica Wium and McAuliffe, Fionnuala and Poston, Lucilla and Roberts, Tracy and Riley, Richard D and Coomarasamy, Arri and Khan, Khalid S. and Mol, Ben-Willem and Thangaratinam, Shakila},
  issn         = {2046-4053},
  language     = {eng},
  month        = {11},
  publisher    = {BioMed Central},
  series       = {Systematic Reviews},
  title        = {Study protocol : Differential effects of diet and physical activity based interventions in pregnancy on maternal and fetal outcomes: Individual patient data (IPD) meta-analysis and health economic evaluation},
  url          = {http://dx.doi.org/10.1186/2046-4053-3-131},
  volume       = {3},
  year         = {2014},
}