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Effect of increased water intake on plasma copeptin in healthy adults

Lemetais, Guillaume; Melander, Olle LU ; Vecchio, Mariacristina; Bottin, Jeanne H.; Enhörning, Sofia LU and Perrier, Erica T. (2017) In European Journal of Nutrition p.1-8
Abstract

Purpose: Inter-individual variation in median plasma copeptin is associated with incident type 2 diabetes mellitus, progression of chronic kidney disease, and cardiovascular events. In this study, we examined whether 24-h urine osmolality was associated with plasma copeptin and whether increasing daily water intake could impact circulating plasma copeptin. Methods: This trial was a prospective study conducted at a single investigating center. Eighty-two healthy adults (age 23.6 ± 2.9 years, BMI 22.2 ± 1.5 kg/m2, 50% female) were stratified based upon habitual daily fluid intake volumes: arm A (50–80% of EFSA dietary reference values), arm B (81–120%), and arm C (121–200%). Following a baseline visit, arms A and B increased... (More)

Purpose: Inter-individual variation in median plasma copeptin is associated with incident type 2 diabetes mellitus, progression of chronic kidney disease, and cardiovascular events. In this study, we examined whether 24-h urine osmolality was associated with plasma copeptin and whether increasing daily water intake could impact circulating plasma copeptin. Methods: This trial was a prospective study conducted at a single investigating center. Eighty-two healthy adults (age 23.6 ± 2.9 years, BMI 22.2 ± 1.5 kg/m2, 50% female) were stratified based upon habitual daily fluid intake volumes: arm A (50–80% of EFSA dietary reference values), arm B (81–120%), and arm C (121–200%). Following a baseline visit, arms A and B increased their water intake to match arm C for a period of 6 consecutive weeks. Results: At baseline, plasma copeptin was positively and significantly associated with 24-h urine osmolality (p = 0.002) and 24-h urine specific gravity (p = 0.003) but not with plasma osmolality (p = 0.18), 24-h urine creatinine (p = 0.09), and total fluid intake (p = 0.52). Over the 6-week follow-up, copeptin decreased significantly from 5.18 (3.3;7.4) to 3.90 (2.7;5.7) pmol/L (p = 0.012), while urine osmolality and urine specific gravity decreased from 591 ± 206 to 364 ± 117 mOsm/kg (p < 0.001) and from 1.016 ± 0.005 to 1.010 ± 0.004 (p < 0.001), respectively. Conclusions: At baseline, circulating levels of copeptin were positively associated with 24-h urine concentration in healthy young subjects with various fluid intakes. Moreover, this study shows, for the first time, that increased water intake over 6 weeks results in an attenuation of circulating copeptin. Clinical Trial Registration Number: NCT02044679.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Copeptin, Fluid intake, Hydration, Urine osmolality, Water intake
in
European Journal of Nutrition
pages
1 - 8
publisher
Springer
external identifiers
  • scopus:85020065289
ISSN
1436-6207
DOI
10.1007/s00394-017-1471-6
language
English
LU publication?
yes
id
95006051-a3d9-411e-b5e4-0d8d4dcd129e
date added to LUP
2017-06-19 10:17:11
date last changed
2017-08-14 10:50:13
@article{95006051-a3d9-411e-b5e4-0d8d4dcd129e,
  abstract     = {<p>Purpose: Inter-individual variation in median plasma copeptin is associated with incident type 2 diabetes mellitus, progression of chronic kidney disease, and cardiovascular events. In this study, we examined whether 24-h urine osmolality was associated with plasma copeptin and whether increasing daily water intake could impact circulating plasma copeptin. Methods: This trial was a prospective study conducted at a single investigating center. Eighty-two healthy adults (age 23.6 ± 2.9 years, BMI 22.2 ± 1.5 kg/m<sup>2</sup>, 50% female) were stratified based upon habitual daily fluid intake volumes: arm A (50–80% of EFSA dietary reference values), arm B (81–120%), and arm C (121–200%). Following a baseline visit, arms A and B increased their water intake to match arm C for a period of 6 consecutive weeks. Results: At baseline, plasma copeptin was positively and significantly associated with 24-h urine osmolality (p = 0.002) and 24-h urine specific gravity (p = 0.003) but not with plasma osmolality (p = 0.18), 24-h urine creatinine (p = 0.09), and total fluid intake (p = 0.52). Over the 6-week follow-up, copeptin decreased significantly from 5.18 (3.3;7.4) to 3.90 (2.7;5.7) pmol/L (p = 0.012), while urine osmolality and urine specific gravity decreased from 591 ± 206 to 364 ± 117 mOsm/kg (p &lt; 0.001) and from 1.016 ± 0.005 to 1.010 ± 0.004 (p &lt; 0.001), respectively. Conclusions: At baseline, circulating levels of copeptin were positively associated with 24-h urine concentration in healthy young subjects with various fluid intakes. Moreover, this study shows, for the first time, that increased water intake over 6 weeks results in an attenuation of circulating copeptin. Clinical Trial Registration Number: NCT02044679.</p>},
  author       = {Lemetais, Guillaume and Melander, Olle and Vecchio, Mariacristina and Bottin, Jeanne H. and Enhörning, Sofia and Perrier, Erica T.},
  issn         = {1436-6207},
  keyword      = {Copeptin,Fluid intake,Hydration,Urine osmolality,Water intake},
  language     = {eng},
  month        = {06},
  pages        = {1--8},
  publisher    = {Springer},
  series       = {European Journal of Nutrition},
  title        = {Effect of increased water intake on plasma copeptin in healthy adults},
  url          = {http://dx.doi.org/10.1007/s00394-017-1471-6},
  year         = {2017},
}