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Automated Operant Assessments of Huntington's Disease Mouse Models

Yhnell, Emma and Heuer, Andreas LU (2018) In Methods in molecular biology (Clifton, N.J.) 1780. p.143-162
Abstract

Huntington's disease (HD) presents clinically with a triad of motor, cognitive, and psychiatric symptoms. Cognitive symptoms often occur early within the disease progression, prior to the onset of motor symptoms, and they are significantly burdensome to people who are affected by HD. In order to determine the suitability of mouse models of HD in recapitulating the human condition, these models must be behaviorally tested and characterized. Operant behavioral testing offers an automated and objective method of behaviorally profiling motor, cognitive, and psychiatric dysfunction in HD mice. Furthermore, operant testing can also be employed to determine any behavioral changes observed after any associated interventions or experimental... (More)

Huntington's disease (HD) presents clinically with a triad of motor, cognitive, and psychiatric symptoms. Cognitive symptoms often occur early within the disease progression, prior to the onset of motor symptoms, and they are significantly burdensome to people who are affected by HD. In order to determine the suitability of mouse models of HD in recapitulating the human condition, these models must be behaviorally tested and characterized. Operant behavioral testing offers an automated and objective method of behaviorally profiling motor, cognitive, and psychiatric dysfunction in HD mice. Furthermore, operant testing can also be employed to determine any behavioral changes observed after any associated interventions or experimental therapeutics. We here present an overview of the most commonly used operant behavioral tests to dissociate motor, cognitive, and psychiatric aspects of mouse models of HD.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
9-Hole box, Behavior, Cognition, Huntington’s disease, Knockin, Mouse model, Operant, Skinner box, Touch screen, Transgenic
in
Methods in molecular biology (Clifton, N.J.)
volume
1780
pages
20 pages
publisher
Springer
external identifiers
  • scopus:85058487381
ISSN
1940-6029
DOI
10.1007/978-1-4939-7825-0_8
language
English
LU publication?
yes
id
953af538-7d65-49b9-87df-f43f44207875
date added to LUP
2019-01-09 14:43:15
date last changed
2019-02-20 11:42:20
@article{953af538-7d65-49b9-87df-f43f44207875,
  abstract     = {<p>Huntington's disease (HD) presents clinically with a triad of motor, cognitive, and psychiatric symptoms. Cognitive symptoms often occur early within the disease progression, prior to the onset of motor symptoms, and they are significantly burdensome to people who are affected by HD. In order to determine the suitability of mouse models of HD in recapitulating the human condition, these models must be behaviorally tested and characterized. Operant behavioral testing offers an automated and objective method of behaviorally profiling motor, cognitive, and psychiatric dysfunction in HD mice. Furthermore, operant testing can also be employed to determine any behavioral changes observed after any associated interventions or experimental therapeutics. We here present an overview of the most commonly used operant behavioral tests to dissociate motor, cognitive, and psychiatric aspects of mouse models of HD.</p>},
  author       = {Yhnell, Emma and Heuer, Andreas},
  issn         = {1940-6029},
  keyword      = {9-Hole box,Behavior,Cognition,Huntington’s disease,Knockin,Mouse model,Operant,Skinner box,Touch screen,Transgenic},
  language     = {eng},
  pages        = {143--162},
  publisher    = {Springer},
  series       = {Methods in molecular biology (Clifton, N.J.)},
  title        = {Automated Operant Assessments of Huntington's Disease Mouse Models},
  url          = {http://dx.doi.org/10.1007/978-1-4939-7825-0_8},
  volume       = {1780},
  year         = {2018},
}