Automated Operant Assessments of Huntington's Disease Mouse Models
(2018) In Methods in molecular biology (Clifton, N.J.) 1780. p.143-162- Abstract
Huntington's disease (HD) presents clinically with a triad of motor, cognitive, and psychiatric symptoms. Cognitive symptoms often occur early within the disease progression, prior to the onset of motor symptoms, and they are significantly burdensome to people who are affected by HD. In order to determine the suitability of mouse models of HD in recapitulating the human condition, these models must be behaviorally tested and characterized. Operant behavioral testing offers an automated and objective method of behaviorally profiling motor, cognitive, and psychiatric dysfunction in HD mice. Furthermore, operant testing can also be employed to determine any behavioral changes observed after any associated interventions or experimental... (More)
Huntington's disease (HD) presents clinically with a triad of motor, cognitive, and psychiatric symptoms. Cognitive symptoms often occur early within the disease progression, prior to the onset of motor symptoms, and they are significantly burdensome to people who are affected by HD. In order to determine the suitability of mouse models of HD in recapitulating the human condition, these models must be behaviorally tested and characterized. Operant behavioral testing offers an automated and objective method of behaviorally profiling motor, cognitive, and psychiatric dysfunction in HD mice. Furthermore, operant testing can also be employed to determine any behavioral changes observed after any associated interventions or experimental therapeutics. We here present an overview of the most commonly used operant behavioral tests to dissociate motor, cognitive, and psychiatric aspects of mouse models of HD.
(Less)
- author
- Yhnell, Emma and Heuer, Andreas LU
- organization
- publishing date
- 2018
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- 9-Hole box, Behavior, Cognition, Huntington’s disease, Knockin, Mouse model, Operant, Skinner box, Touch screen, Transgenic
- in
- Methods in molecular biology (Clifton, N.J.)
- volume
- 1780
- pages
- 20 pages
- publisher
- Springer
- external identifiers
-
- pmid:29856018
- scopus:85058487381
- ISSN
- 1940-6029
- DOI
- 10.1007/978-1-4939-7825-0_8
- language
- English
- LU publication?
- yes
- id
- 953af538-7d65-49b9-87df-f43f44207875
- date added to LUP
- 2019-01-09 14:43:15
- date last changed
- 2024-01-30 07:22:52
@article{953af538-7d65-49b9-87df-f43f44207875,
abstract = {{<p>Huntington's disease (HD) presents clinically with a triad of motor, cognitive, and psychiatric symptoms. Cognitive symptoms often occur early within the disease progression, prior to the onset of motor symptoms, and they are significantly burdensome to people who are affected by HD. In order to determine the suitability of mouse models of HD in recapitulating the human condition, these models must be behaviorally tested and characterized. Operant behavioral testing offers an automated and objective method of behaviorally profiling motor, cognitive, and psychiatric dysfunction in HD mice. Furthermore, operant testing can also be employed to determine any behavioral changes observed after any associated interventions or experimental therapeutics. We here present an overview of the most commonly used operant behavioral tests to dissociate motor, cognitive, and psychiatric aspects of mouse models of HD.</p>}},
author = {{Yhnell, Emma and Heuer, Andreas}},
issn = {{1940-6029}},
keywords = {{9-Hole box; Behavior; Cognition; Huntington’s disease; Knockin; Mouse model; Operant; Skinner box; Touch screen; Transgenic}},
language = {{eng}},
pages = {{143--162}},
publisher = {{Springer}},
series = {{Methods in molecular biology (Clifton, N.J.)}},
title = {{Automated Operant Assessments of Huntington's Disease Mouse Models}},
url = {{http://dx.doi.org/10.1007/978-1-4939-7825-0_8}},
doi = {{10.1007/978-1-4939-7825-0_8}},
volume = {{1780}},
year = {{2018}},
}