Intravascular haemolysis and increased prevalence of myeloma and monoclonal gammopathy in congenital dyserythropoietic anaemia, type III
(1994) In European Journal of Haematology 52(1). p.42-46- Abstract
Abstract: A family with congenital dyserythropoietic anaemia type III was studied. Twenty patients and 10 of their healthy siblings were clinically examined and questioned about their medical history. Blood sampling and bone marrow aspirations were also performed. Forty‐five percent of the patients reported symptoms of anaemia and 35% regularly felt weakness, fatigue, or headache. However, the majority of the patients regarded themselves as healthy. The bone marrow showed a uniform picture of erythroid hyperplasia with multinuclear erythroblasts and gigantoblasts with up to 12 nuclei. There was laboratory evidence of intravascular haemolysis and mild anaemia. We also observed a high prevalence of monoclonal gammopathy of undetermined... (More)
Abstract: A family with congenital dyserythropoietic anaemia type III was studied. Twenty patients and 10 of their healthy siblings were clinically examined and questioned about their medical history. Blood sampling and bone marrow aspirations were also performed. Forty‐five percent of the patients reported symptoms of anaemia and 35% regularly felt weakness, fatigue, or headache. However, the majority of the patients regarded themselves as healthy. The bone marrow showed a uniform picture of erythroid hyperplasia with multinuclear erythroblasts and gigantoblasts with up to 12 nuclei. There was laboratory evidence of intravascular haemolysis and mild anaemia. We also observed a high prevalence of monoclonal gammopathy of undetermined significance (3 cases) and myeloma (1 case) among the patients.
(Less)
- author
- Sandström, Herbert ; Wahlin, Anders ; Eriksson, Mikael LU ; Bergström, Ingmar and Wickramasinghe, Sunitha N.
- publishing date
- 1994-01-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- autosomal dominant, CDA, haemolytic anaemia, haemosiderinuria, monoclonal gammopathy, myeloma, type III
- in
- European Journal of Haematology
- volume
- 52
- issue
- 1
- pages
- 42 - 46
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:0028155927
- pmid:8299769
- ISSN
- 0902-4441
- DOI
- 10.1111/j.1600-0609.1994.tb01283.x
- language
- English
- LU publication?
- no
- id
- 956ee0b6-ae02-4307-b337-ed5b0818bcf3
- date added to LUP
- 2020-03-30 16:37:52
- date last changed
- 2024-04-03 03:32:28
@article{956ee0b6-ae02-4307-b337-ed5b0818bcf3, abstract = {{<p>Abstract: A family with congenital dyserythropoietic anaemia type III was studied. Twenty patients and 10 of their healthy siblings were clinically examined and questioned about their medical history. Blood sampling and bone marrow aspirations were also performed. Forty‐five percent of the patients reported symptoms of anaemia and 35% regularly felt weakness, fatigue, or headache. However, the majority of the patients regarded themselves as healthy. The bone marrow showed a uniform picture of erythroid hyperplasia with multinuclear erythroblasts and gigantoblasts with up to 12 nuclei. There was laboratory evidence of intravascular haemolysis and mild anaemia. We also observed a high prevalence of monoclonal gammopathy of undetermined significance (3 cases) and myeloma (1 case) among the patients.</p>}}, author = {{Sandström, Herbert and Wahlin, Anders and Eriksson, Mikael and Bergström, Ingmar and Wickramasinghe, Sunitha N.}}, issn = {{0902-4441}}, keywords = {{autosomal dominant; CDA; haemolytic anaemia; haemosiderinuria; monoclonal gammopathy; myeloma; type III}}, language = {{eng}}, month = {{01}}, number = {{1}}, pages = {{42--46}}, publisher = {{Wiley-Blackwell}}, series = {{European Journal of Haematology}}, title = {{Intravascular haemolysis and increased prevalence of myeloma and monoclonal gammopathy in congenital dyserythropoietic anaemia, type III}}, url = {{http://dx.doi.org/10.1111/j.1600-0609.1994.tb01283.x}}, doi = {{10.1111/j.1600-0609.1994.tb01283.x}}, volume = {{52}}, year = {{1994}}, }