Fluctuations of the transcription factor ATML1 generate the pattern of giant cells in the Arabidopsis sepal
(2017) In eLife- Abstract
- Multicellular development produces patterns of specialized cell types. Yet, it is often unclear how individual cells within a field of identical cells initiate the patterning process. Using live imaging, quantitative image analyses and modeling, we show that during Arabidopsis thaliana sepal development, fluctuations in the concentration of the transcription factor ATML1 pattern a field of identical epidermal cells to differentiate into giant cells interspersed between smaller cells. We find that ATML1 is expressed in all epidermal cells. However, its level fluctuates in each of these cells. If ATML1 levels surpass a threshold during the G2 phase of the cell cycle, the cell will likely enter a state of endoreduplication and become giant.... (More)
- Multicellular development produces patterns of specialized cell types. Yet, it is often unclear how individual cells within a field of identical cells initiate the patterning process. Using live imaging, quantitative image analyses and modeling, we show that during Arabidopsis thaliana sepal development, fluctuations in the concentration of the transcription factor ATML1 pattern a field of identical epidermal cells to differentiate into giant cells interspersed between smaller cells. We find that ATML1 is expressed in all epidermal cells. However, its level fluctuates in each of these cells. If ATML1 levels surpass a threshold during the G2 phase of the cell cycle, the cell will likely enter a state of endoreduplication and become giant. Otherwise, the cell divides. Our results demonstrate a fluctuation-driven patterning mechanism for how cell fate decisions can be initiated through a random yet tightly regulated process. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/9576acab-ebc5-46a5-a989-604d22b34fe0
- author
- Meyer, Heather M ; Teles, José LU ; Formosa-Jordan, Pau ; Refahi, Yassin ; San-Bento, Rita ; Ingram, Gwyneth ; Jönsson, Henrik LU ; Locke, James C.W. and Roeder, Adrienne H K
- organization
- publishing date
- 2017-02-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- eLife
- publisher
- eLife Sciences Publications
- external identifiers
-
- scopus:85014615875
- ISSN
- 2050-084X
- DOI
- 10.7554/eLife.19131.001
- language
- English
- LU publication?
- yes
- id
- 9576acab-ebc5-46a5-a989-604d22b34fe0
- date added to LUP
- 2019-07-31 16:45:25
- date last changed
- 2024-04-16 18:06:05
@article{9576acab-ebc5-46a5-a989-604d22b34fe0, abstract = {{Multicellular development produces patterns of specialized cell types. Yet, it is often unclear how individual cells within a field of identical cells initiate the patterning process. Using live imaging, quantitative image analyses and modeling, we show that during Arabidopsis thaliana sepal development, fluctuations in the concentration of the transcription factor ATML1 pattern a field of identical epidermal cells to differentiate into giant cells interspersed between smaller cells. We find that ATML1 is expressed in all epidermal cells. However, its level fluctuates in each of these cells. If ATML1 levels surpass a threshold during the G2 phase of the cell cycle, the cell will likely enter a state of endoreduplication and become giant. Otherwise, the cell divides. Our results demonstrate a fluctuation-driven patterning mechanism for how cell fate decisions can be initiated through a random yet tightly regulated process.}}, author = {{Meyer, Heather M and Teles, José and Formosa-Jordan, Pau and Refahi, Yassin and San-Bento, Rita and Ingram, Gwyneth and Jönsson, Henrik and Locke, James C.W. and Roeder, Adrienne H K}}, issn = {{2050-084X}}, language = {{eng}}, month = {{02}}, publisher = {{eLife Sciences Publications}}, series = {{eLife}}, title = {{Fluctuations of the transcription factor ATML1 generate the pattern of giant cells in the Arabidopsis sepal}}, url = {{http://dx.doi.org/10.7554/eLife.19131.001}}, doi = {{10.7554/eLife.19131.001}}, year = {{2017}}, }