Advanced

Design and Synthesis of New Models for Diiron Biosites

Trukhan, Vladimir; Gritsenko, Olga; Nordlander, Ebbe LU and Shteinman, Albert (2000) In Journal of Inorganic Biochemistry 79(1-4). p.41-46
Abstract
In order to mimic dinuclear active sites of some non-heme diiron proteins, ten new polydentate and potentially dinucleating ligands have been synthesized. Each ligand contains a carboxylate moiety designed to bridge two metal atoms. These central carboxylate moieties are derived from substituted benzoic acids that in turn are linked to terminal nitrogen or oxygen donors by spacers so that framework-type polydentate ligands similar to the polypeptide frames in diiron metallobiosites are formed. Reaction of these ligands with Fe(ClO4)3·9H2O leads to ferric μ-oxo-μ-carboxylato iron complexes of the general formulas [Fe2O(L)2(H2O)2](ClO4)2 and [Fe2O(L)(BzO)](ClO4)2 (L=ligand), containing one or two immobilized bridging carboxylates,... (More)
In order to mimic dinuclear active sites of some non-heme diiron proteins, ten new polydentate and potentially dinucleating ligands have been synthesized. Each ligand contains a carboxylate moiety designed to bridge two metal atoms. These central carboxylate moieties are derived from substituted benzoic acids that in turn are linked to terminal nitrogen or oxygen donors by spacers so that framework-type polydentate ligands similar to the polypeptide frames in diiron metallobiosites are formed. Reaction of these ligands with Fe(ClO4)3·9H2O leads to ferric μ-oxo-μ-carboxylato iron complexes of the general formulas [Fe2O(L)2(H2O)2](ClO4)2 and [Fe2O(L)(BzO)](ClO4)2 (L=ligand), containing one or two immobilized bridging carboxylates, respectively. While X-ray crystallography shows that some of these complexes are dimers or network polymers in the solid state, electrospray ionization mass spectrometry (ESMS) and spectroscopic data (UV–Vis, NMR, Mössbauer) indicate that they dissociate to monomeric Fe2O units in dilute CH3CN solutions. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Diiron biosites, Modeling, Framework ligands, Fe(III) complexes
in
Journal of Inorganic Biochemistry
volume
79
issue
1-4
pages
41 - 46
publisher
Elsevier
external identifiers
  • scopus:0034732623
ISSN
1873-3344
DOI
10.1016/S0162-0134(99)00244-5
language
English
LU publication?
yes
id
270b83f4-9dbc-44cc-9c64-de25c33327d1 (old id 959619)
date added to LUP
2008-08-18 12:04:37
date last changed
2017-01-01 07:08:18
@article{270b83f4-9dbc-44cc-9c64-de25c33327d1,
  abstract     = {In order to mimic dinuclear active sites of some non-heme diiron proteins, ten new polydentate and potentially dinucleating ligands have been synthesized. Each ligand contains a carboxylate moiety designed to bridge two metal atoms. These central carboxylate moieties are derived from substituted benzoic acids that in turn are linked to terminal nitrogen or oxygen donors by spacers so that framework-type polydentate ligands similar to the polypeptide frames in diiron metallobiosites are formed. Reaction of these ligands with Fe(ClO4)3·9H2O leads to ferric μ-oxo-μ-carboxylato iron complexes of the general formulas [Fe2O(L)2(H2O)2](ClO4)2 and [Fe2O(L)(BzO)](ClO4)2 (L=ligand), containing one or two immobilized bridging carboxylates, respectively. While X-ray crystallography shows that some of these complexes are dimers or network polymers in the solid state, electrospray ionization mass spectrometry (ESMS) and spectroscopic data (UV–Vis, NMR, Mössbauer) indicate that they dissociate to monomeric Fe2O units in dilute CH3CN solutions.},
  author       = {Trukhan, Vladimir and Gritsenko, Olga and Nordlander, Ebbe and Shteinman, Albert},
  issn         = {1873-3344},
  keyword      = {Diiron biosites,Modeling,Framework ligands,Fe(III) complexes},
  language     = {eng},
  number       = {1-4},
  pages        = {41--46},
  publisher    = {Elsevier},
  series       = {Journal of Inorganic Biochemistry},
  title        = {Design and Synthesis of New Models for Diiron Biosites},
  url          = {http://dx.doi.org/10.1016/S0162-0134(99)00244-5},
  volume       = {79},
  year         = {2000},
}