Understanding the bioreactor
(2002) In Bioprocess and Biosystems Engineering 24(5). p.273-279- Abstract
- Analysis of bioreactors is central for successful design and operation of biotechnical processes. The bioreactor should provide optimum conditions, with respect to temperature, pH and substrate condition, for example, besides its basic function of containment. The ability to control the substrate concentration is an important function of the bioreactor. The substrate concentration can be subject to spatial variation-advertently or inadvertently and may also change with time in batch or fed-batch operation. The cellular metabolism will depend on local concentrations in the reactor, as well as on the physiological status of the cell. in order to understand the bioreactor operation, cellular metabolism must be considered together with the... (More)
- Analysis of bioreactors is central for successful design and operation of biotechnical processes. The bioreactor should provide optimum conditions, with respect to temperature, pH and substrate condition, for example, besides its basic function of containment. The ability to control the substrate concentration is an important function of the bioreactor. The substrate concentration can be subject to spatial variation-advertently or inadvertently and may also change with time in batch or fed-batch operation. The cellular metabolism will depend on local concentrations in the reactor, as well as on the physiological status of the cell. in order to understand the bioreactor operation, cellular metabolism must be considered together with the flow profile and the mass transfer characteristics of the bioreactor. Some fundamental aspects of bioreactor operation for yeast and bacterial cultivations are discussed in this short review. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/343532
- author
- Lidén, Gunnar LU
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- bioreactor analysis, fed-batch control, gradients
- in
- Bioprocess and Biosystems Engineering
- volume
- 24
- issue
- 5
- pages
- 273 - 279
- publisher
- Springer
- external identifiers
-
- wos:000173905900003
- scopus:0035706619
- ISSN
- 1615-7605
- DOI
- 10.1007/s004490100263
- language
- English
- LU publication?
- yes
- id
- 95aeff23-01d1-4b7b-b21a-f77d899813c5 (old id 343532)
- date added to LUP
- 2016-04-01 16:39:14
- date last changed
- 2023-11-14 15:22:45
@article{95aeff23-01d1-4b7b-b21a-f77d899813c5,
abstract = {{Analysis of bioreactors is central for successful design and operation of biotechnical processes. The bioreactor should provide optimum conditions, with respect to temperature, pH and substrate condition, for example, besides its basic function of containment. The ability to control the substrate concentration is an important function of the bioreactor. The substrate concentration can be subject to spatial variation-advertently or inadvertently and may also change with time in batch or fed-batch operation. The cellular metabolism will depend on local concentrations in the reactor, as well as on the physiological status of the cell. in order to understand the bioreactor operation, cellular metabolism must be considered together with the flow profile and the mass transfer characteristics of the bioreactor. Some fundamental aspects of bioreactor operation for yeast and bacterial cultivations are discussed in this short review.}},
author = {{Lidén, Gunnar}},
issn = {{1615-7605}},
keywords = {{bioreactor analysis; fed-batch control; gradients}},
language = {{eng}},
number = {{5}},
pages = {{273--279}},
publisher = {{Springer}},
series = {{Bioprocess and Biosystems Engineering}},
title = {{Understanding the bioreactor}},
url = {{http://dx.doi.org/10.1007/s004490100263}},
doi = {{10.1007/s004490100263}},
volume = {{24}},
year = {{2002}},
}